Assessing the relative effectiveness and tolerability of treatments in small cell lung cancer: A network meta-analysis

Bakalos, Georgios; Miligkos, Michael; Doxani, Chrysoula; Mpoulimari, Ioanna; Rodopoulou, Paraskevi; Ζιντζαράς, Ηλίας

doi:10.1016/j.canep.2013.06.008

Cited by 5 publications

(2 citation statements)

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“…Existen publicaciones de MTC en áreas como reumatología [15][16][17][18][19][20][21] , psiquiatría [22][23][24][25][26][27] , oncología [28][29][30] , oftalmología [31][32][33] , cardiología [34][35][36][37][38] , cirugía 33 , dermatología [39][40][41][42] , neumología [43][44][45][46][47] , medicina interna [48][49][50][51][52] , urología 53 , ortopedia [54][55] , ginecología [56][57] o nefrología [58][59] .…”

Section: Ejemplos De Mtcunclassified

Aproximación a los metanálisis de comparación de múltiples tratamientos: una revisión de la literatura

Gómez¹,

Isaza

Gómez

2019

MedUPB

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RESUMENLos metanálisis de comparación de múltiples tratamientos permiten estudiar, a partir de revisiones sistemáticas, las comparaciones realizadas de forma directa o indirecta, sobre diversos tipos de intervenciones, con datos de varios ensayos clínicos que, por su homogeneidad en los resultados, pueden agruparse en un resultado común y expresable de manera cuantitativa. Otros nombres que recibe son: metanálisis en red, metanálisis de comparación mixta o metanálisis indirectos. Al permitir la comparación de varios tratamientos facilitan una mejor estimación del efecto de las intervenciones, lo que guía de forma más certera al clínico en sus decisiones y en la aplicación de la información en el cuidado de sus pacientes. El objetivo de esta revisión es guiar al lector para que realice de manera organizada y adecuada la lectura crítica (según recomendaciones JAMA) de los metanálisis de comparación de múltiples tratamientos. Este artículo está orientando a los autores y a los editores, y contiene información sobre cómo deben interpretarse y comunicarse estos estudios. Palabras clave: metanálisis como asunto; terapéutica; práctica clínica basada en la evidencia ABSTRACT Multiple treatment comparison meta-analyses are systematic reviews that allow to make direct or indirect comparisons of different interventions from the data collection results of randomized clinical trials, grouping them in a common outcome or conglomerate which is expressed quantitatively. Other names given are network meta-analyses, or mixed treatment comparison meta-analyses or indirect meta-analyses. The use of the comparison of several treatments allows a greater estimation of the intervention effect. This is a guide for the physician to make more accurate decisions and to apply better care criteria to their patients. This literature review should help the reader to perform an organized and adequate critical reading (according to the JAMA recommendations) of the multiple treatment comparison meta-analyses. The article is addressed to authors and editors, and it contains information on how this type of studies should be interpreted and communicated.

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Section: Ejemplos De Mtcunclassified

Aproximación a los metanálisis de comparación de múltiples tratamientos: una revisión de la literatura

Gómez¹,

Isaza

Gómez

2019

MedUPB

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“…Despite the fact that some traditional pairwise meta‐analyses have assessed the safety of front‐line chemotherapies for the treatment ED‐SCLC, none of these studies conducted a comprehensive evaluation of the four available front‐line chemotherapy regimens; comparisons were only made between two chemotherapy regimens, which failed to provide a rank of the comparative effectiveness of multiple interventions . Recently, Bakalos et al conducted a network meta‐analysis to estimate the effectiveness and tolerability of chemotherapy regimens in SCLC . However, this study did not distinguish patients with extensive stage from those with limited stage, which made for less convincing conclusions.…”

Section: Introductionmentioning

confidence: 99%

Comparing the adverse effects of platinum in combination with etoposide or irinotecan in previously untreated small‐cell lung cancer patients with extensive disease: A network meta‐analyses

Chen

Zhong

2017

Thoracic Cancer

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BackgroundThe safety of front‐line chemotherapies for the treatment of extensive stage small‐cell lung cancer (ED‐SCLC) is uncertain. We carried out a network meta‐analysis to compare the toxicity of different therapies for ED‐SCLC.MethodsWe searched EMBASE, PubMed, CENTRAL and clinicaltrials.gov. We performed network meta‐analysis on hematological (anemia, leukopenia, neutropenia, and thrombocytopenia) and non‐hematological toxicities (diarrhea, infection, and nausea and vomiting).ResultsNine studies with 2317 patients were included. Etoposide with carboplatin (EC) was associated with a higher incidence of anemia (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.13–3.63), leukopenia (OR 2.67, 95% CI 1.25–5.72), neutropenia (OR 12.08, 95% CI 2.13–68.66), and thrombocytopenia (OR 2.73, 95% CI 1.27–5.85) compared with irinotecan with carboplatin (IC). Similarly, etoposide with cisplatin (EP) was associated with a higher incidence of anemia (OR 1.70, 95% CI 1.13–2.56), leukopenia (OR 2.65, 95% CI 1.34–5.28), neutropenia (OR 5.70, 95% CI 2.93–11.10), and thrombocytopenia (OR 3.26, 95% CI 1.66–6.38) compared with irinotecan with cisplatin (IP). EC was associated with a lower incidence of diarrhea (OR 0.26, 95% CI 0.10–0.68) compared with IC, and EP was associated with a lower incidence of diarrhea (OR 0.09, 95% CI 0.03–0.25) and nausea and vomiting (OR 0.53, 95% CI 0.33–0.84) than IP.ConclusionsHematological toxicities were most common in EC‐treated patients, while the lowest incidence occurred with IP treatment. The IP regimen was associated with the highest incidence of toxicities of the digestive tract, while the lowest incidence occurred with EC treatment.

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Differenzialtherapie des fortgeschrittenen metastasierten kleinzelligen Lungenkarzinoms

Sebastian

Stratmann

2017

Onkologe

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Assessing the relative effectiveness and tolerability of treatments in small cell lung cancer: A network meta-analysis

Cited by 5 publications

References 45 publications

Aproximación a los metanálisis de comparación de múltiples tratamientos: una revisión de la literatura

Aproximación a los metanálisis de comparación de múltiples tratamientos: una revisión de la literatura

Comparing the adverse effects of platinum in combination with etoposide or irinotecan in previously untreated small‐cell lung cancer patients with extensive disease: A network meta‐analyses

Differenzialtherapie des fortgeschrittenen metastasierten kleinzelligen Lungenkarzinoms

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