Assessing the risk of an excess fluoride intake among Swedish children in households with private wells — Expanding static single-source methods to a probabilistic multi-exposure-pathway approach

Augustsson, Anna; Berger, Tobias

doi:10.1016/j.envint.2014.03.014

Cited by 38 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite some of the benefits of fluoride in the body, the effects of acute fluoride toxicity have been well documented in several literatures. Some researchers, such as Anna Augustsson from Sweden, have studied the risk assessment of fluoride intake from various sources, including food and beverage (tea, water, and other drinks), toothpaste, soil particles, and certain medications in 2014 and found that fluoride intake through drinking water is 77 % in comparison with other factors (Augustsson and Berger 2014). The minimum risk level of 0.05 mg/kg/d calculated by Agency for Toxic Substances and Disease Registry, and Battaleb-Looie et al (2013) estimated the maximum fluoride intakes (from dates and drinking water) for children and adults were 3.4 and 1.6 times higher than the minimum risk level, respectively (Battaleb-Looie et al 2013).…”

Section: Resultsmentioning

confidence: 99%

Fluoride in Drinking Water in 31 Provinces of Iran

et al. 2016

View full text Add to dashboard Cite

The effects of acute fluoride toxicity have been well documented in the literature. Drinking water is an important source of fluoride intake by humans, hence studies need to be carried out to determine the concentration of Fluoride in water. Therefore, this study tends to demonstrate the fluoride concentration in drinking water in thirty-one provinces of Iran during 2014. This cross-sectional study on drinking water was conducted in 2014. SPADNS method was determined for fluoride concentration examination according to instruction of Standard Methods. The minimum concentration of fluoride in provinces, such as Fars, Kermanshah, Kohgiluyeh and BoyerAhmad, Markazi, and Hormozgan, was observed to be 0.01 mg/L, while the maximum concentrations were observed to be 3.72 and 3.52 mg/L for Bushehr and Fars, respectively. The minimum and maximum average mean concentrations were 0.193 (SD = 0.11) and 0.889 (SD = 0.31) for Kermanshah and Bushehr, respectively. Due to the disadvantages of fluoride and because of the existence of different ecological conditions in Iran, there are different concentrations of water fluoride in the country. Therefore, proper policies should be made for water treatment plants based on the regional conditions in order to achieve a desirable fluoride concentration standard.

show abstract

Section: Resultsmentioning

confidence: 99%

Fluoride in Drinking Water in 31 Provinces of Iran

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Over the past decade, several studies have focused on the effects of environmental toxins on the human endocrine system, including the impact of fluoride on the thyroid gland 1 , 2 . Globally, millions of people suffer from thyroid-related problems.…”

Section: Introductionmentioning

confidence: 99%

Impact of Drinking Water Fluoride on Human Thyroid Hormones: A Case- Control Study

Kheradpisheh

Mirzaei

Mahvi

et al. 2018

Sci Rep

View full text Add to dashboard Cite

The elevated fluoride from drinking water impacts on T 3 , T 4 and TSH hormones. The aim was study impacts of drinking water fluoride on T 3 , T 4 and TSH hormones inYGA (Yazd Greater Area). In this case-control study 198 cases and 213 controls were selected. Fluoride was determined by the SPADNS Colorimetric Method. T 3 , T 4 and TSH hormones tested in the Yazd central laboratory by RIA (Radio Immuno Assay) method. The average amount of TSH and T 3 hormones based on the levels of fluoride in two concentration levels 0-0.29 and 0.3-0.5 (mg/L) was statistically significant (P = 0.001 for controls and P = 0.001 for cases). In multivariate regression logistic analysis, independent variable associated with Hypothyroidism were: gender (odds ratio: 2.5, CI 95%: 1.6-3.9), family history of thyroid disease (odds ratio: 2.7, CI 95%: 1.6-4.6), exercise (odds ratio: 5.34, CI 95%: 3.2-9), Diabetes (odds ratio: 3.7, CI 95%: 1.7-8), Hypertension (odds ratio: 3.2, CI 95%: 1.3-8.2), water consumption (odds ratio: 4, CI 95%: 1.2-14). It was found that fluoride has impacts on TSH, T 3 hormones even in the standard concentration of less than 0.5 mg/L. Application of standard household water purification devices was recommended for hypothyroidism.Over the past decade, several studies have focused on the effects of environmental toxins on the human endocrine system, including the impact of fluoride on the thyroid gland 1,2 . Globally, millions of people suffer from thyroid-related problems. When the thyroid gland does not function properly, it can affect multiple aspects of our health [3][4][5] . The most important effect is thyroid complications in pregnant women. Uncontrolled hypothyroidism can raise the blood pressure during late pregnancy, increase the risk of miscarriage and preterm delivery, and affect brain development and growth rate 3-5 . The incidence of thyroid cancer has risen from 2% to 5% per decade. If this trend continues, thyroid cancer may become the fourth most common cancer in the United States by 2030 6 . The incidence rate of this type of cancer is two times more in high-income and middle-income countries as compared to low-income countries. It has a three to four time's higher probability of occurring in women than in men 6 . The adverse effects of fluoride on animal and human health are well documented in the literature 7,8 . The effects of high fluoride ingestion through drinking water, green tea, and ambient air pollution on thyroid hormones (T3, T4, TH, and TSH) were investigated in both humans and animals. Some studies reported a reduction in the T4 and T3 levels as well as an abnormal increase in the TSH levels 9-15 . said that even at 1 mg/L of fluoride in water, T3 levels reduced in teenagers living in Northern Mexico 16 . During the years 2007-2016, the Parents of Fluoride Poisoned Children (PFPC) has reported over 190 studies on the effects of fluoride on thyroid hormones, including studies on both animals and humans 17 . Some studies have discovered the relation between dental fluorosis and thyroid...

show abstract

“…3 Over the past decade, several studies have focused on the effects of environmental toxins on the human endocrine system including the impact of fluoride on the thyroid gland. 4,5 Significant population suffers from thyroid associated problems worldwide and its dysfunction is reflected pathologically and biochemically. Pregnant women are more vulnerable with rise of high blood pressure and miscarriage and there is a potential rise of affliction of the brain of the growing foetus consequently.…”

Section: Introductionmentioning

confidence: 99%

Cytomorphological alterations of thyroid gland consequent upon fluorosis

et al. 2019

View full text Add to dashboard Cite

Background: Study aimed at assessing the impact of elevated fluoride from drinking water on thyroid gland structure and function in fluorosis prone areas. Iodine is incorporated in the thyroid synthesis by thyroid gland but in the presence of low Iodine levels fluoride is likely to interfere with the concentrating capacity of thyroid of iodine in thyroid production, consequently reflecting changes in thyroid parameters and also cytomorphological features manifesting hypothyroidism in association with different pathological entities.Methods: Prakasam district in Andhra Pradesh is fluorosis prone zone and subjects are picked up from highly vulnerable zone in this district and their specimens are collected to study cytomorphological changes of the thyroid gland and biochemical parameters of blood samples for thyroid function test were considered. Cytological study by way of Fine Needle Aspiration Cytology (FNAC) of thyroid gland, biochemical parameters pertaining to function of thyroid gland namely Free triiodothyronine (FT3), Free Thyroxine (FT4) and Thyroid stimulating hormone (TSH) were assessed in the subjects from fluorosis prone zone.Results: The results were statistically significant with concurrent association of different cytological alterations of thyroid gland in these subjects like Hashimoto’s thyroiditis of hypothyroidism, adenomatous goitre, colloid goitre and few of follicular adenoma/neoplasm. FNAC makes cytological changes evident showing different morphological features that comprise different pathological entities largely with an evidence of hypothyroidism in most of the cases in the given study.Conclusions: The results of the study strongly suggest assessing the magnitude of the problem of fluorosis and also magnitude of its influence on thyroid structure and function that warrants assessment of the thyroid function by biochemical and cytological studies.

show abstract

Assessing the risk of an excess fluoride intake among Swedish children in households with private wells — Expanding static single-source methods to a probabilistic multi-exposure-pathway approach

Cited by 38 publications

References 38 publications

Fluoride in Drinking Water in 31 Provinces of Iran

Fluoride in Drinking Water in 31 Provinces of Iran

Impact of Drinking Water Fluoride on Human Thyroid Hormones: A Case- Control Study

Cytomorphological alterations of thyroid gland consequent upon fluorosis

Contact Info

Product

Resources

About