Assessing the Usefulness of Severity Markers in Women with Ovarian Hyperstimulation Syndrome

Petrenko, Aleksei; Castelo-Branco, Camil; Marshalov, D.V.; Kuligin, A.V.; Shifman, E.М.; Nesnova, Elena Sergeevna

doi:10.1007/s43032-020-00339-8

Cited by 3 publications

(4 citation statements)

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“…In a previous study, we made an analogy between OHSS and IAH syndrome documenting the importance of dynamic monitoring of IAP, AsI and OV. All these parameters were significantly associated with the OHSS severity [ 8 ]. In the present research, we studied the women’s anthropometric data and their relationship with OHSS severity.…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian size and pelvic and abdominal free fluid were assessed by ultrasound (Accuvix XG [Samsung MEDISON Co. Ltd. Korea]) using 3.5 MHz sectoral sensors. The ovarian volume (OV) using the prolate ellipsoid formula [ 13 ] and the AsI [ 14 ] was measured as previously described [ 8 ]. Finally, the IAP was determined using a Foley catheter with a pressure transducer [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

“…Ascites progression and ovarian enlargement with OHSS leads to an increase in intra-abdominal pressure (IAP), and in severe and critical formsto the abdominal compartment syndrome (ACS) and associated severe organ dysfunction, which is the main factor of poor outcome among women with this syndrome [ 6 , 7 ]. Our previous study revealed OHSS as a classic model of intra-abdominal hypertension (IAH) syndrome, where IAP is an important diagnostic marker, allied with the OHSS severity [ 8 ]. It has been proposed, there was provided to use the IAH level and ascites index (AsI), for paracentesis's indications in combination with clinical and laboratory data.…”

Section: Introductionmentioning

confidence: 99%

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Are anthropometric data a tool for determining the severity of OHSS? Yes, it could be!

et al. 2022

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Background All management guidelines of ovarian hyperstimulation syndrome (OHSS) recommend daily monitoring of women's body weight, waist circumference and note that as indicators increase, the severity OHSS also increases. However, the dynamics of abdominal size and its relationship with markers of OHSS severity have not been highlighted. The purpose of this study is to assess the usefulness of various anthropometric indicators for determining the degree of OHSS severity as well as paracentesis indications. Methods Observational study including 76 women complaining with OHSS. Clinical history, physical examination, laboratory tests, and ultrasound measurement of the ovarian volume (OV) and ascites index (AsI) were done in all cases. Intra-abdominal pressure (IAP) was assessed using an intravesical manometer. The anteroposterior diameter of the abdomen (APD) and transverse diameter of the abdomen (TS) were measured with a pelvimeter. The APD/TS ratio was calculated. Results The APD/TS ratio increased progressively and tended to be the highest in the most symptomatic stage of OHSS (Kruskal–Wallis test, p < 0.001). The median APD/TS was significantly lower in patients with mild OHSS (0.55 [IQR, 0.44–0.64]) compared with severe OHSS (0.87 [IQR, 0.80–0.93]; p < 0.001) or critical OHSS (1.04 [IQR, 1.04–1.13]; p < 0.001). Similarly, the median APD/TS of the moderate OHSS group (0.65 [IQR, 0.61–0.70]) was significantly lower than that of the severe (p < 0.001) and critical OHSS group (p = 0.001). There was a strong positive correlation between APD/TS and IAP (Spearman’s r = 0.886, p < 0.01). The APD/TS ratio showed a significant positive correlation with AsI (Spearman’s r = 0.695, p < 0.01) and OV (Spearman’s r = 0.622, p < 0.01). No significant differences were observed in age, height, weight, body mass index, hip circumference or waist circumference between moderate, severe and critical OHSS groups. Conclusions The APD/TS ratio is related to the severity of OHSS. Monitoring APD/TS dynamics could be a method of indirectly controlling intra-abdominal volume, compliance of the abdominal wall and IAP. In conjunction with clinical and laboratory data, APD/TS might be an indicator for paracentesis.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Are anthropometric data a tool for determining the severity of OHSS? Yes, it could be!

et al. 2022

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“…Although a serious complication of ART, OHSS is an uncommon adverse physiologic reaction complicating approximately 1% of IVF cycles ( 7 ). Severe cases of OHSS requiring hospitalization are even rarer and may manifest as adult respiratory distress syndrome, pulmonary thromboembolism, or ascites and abdominal compartment syndrome ( 8 , 9 , 10 ). Severity markers of OHSS have been proposed recently, including intraabdominal pressure, ascites index, and ovarian volume, although these remain to be validated in terms of clinical utility and prognostic value ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Severe ovarian hyperstimulation syndrome requiring recurrent large-volume paracenteses until 21 weeks’ gestation: a case report

et al. 2022

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Ovarian hyperstimulation syndrome and intra-abdominal hypertension: a systematic review

Petrenko,

Shifman,

Castelo-Branco

et al. 2024

Rus. J. Anes. Reanim.

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Assessing the Usefulness of Severity Markers in Women with Ovarian Hyperstimulation Syndrome

Cited by 3 publications

References 25 publications

Are anthropometric data a tool for determining the severity of OHSS? Yes, it could be!

Are anthropometric data a tool for determining the severity of OHSS? Yes, it could be!

Severe ovarian hyperstimulation syndrome requiring recurrent large-volume paracenteses until 21 weeks’ gestation: a case report

Ovarian hyperstimulation syndrome and intra-abdominal hypertension: a systematic review

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