Assessing the utility of contact tracing in reducing the magnitude of tuberculosis

Shrivastava, Saurabh RamBihariLal; Shrivastava, PrateekSaurabh; Ramasamy, Jegadeesh

doi:10.3402/iee.v4.25265

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…This triggered the Gates foundation and WHO to look at solutions, which can be deployed at the patient site. The smart pill boxes, smart pill sachets with barcodes, mobile tracking and alerting consider as options [13, 14]. These methods are still subjective and assume that the TB patient is educated enough to SMS some complex numbers printed on the tablet strip or committed enough to take the tablet regularly [15, 16].…”

Section: Introductionmentioning

confidence: 99%

Objective measurement of isoniazid levels: practical approach for monitoring tuberculosis drug treatment adherence

Korrapati

Muneppa

Pullela

et al. 2017

IET nanobiotechnol.

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Drug treatment adherence is one of the biggest issues in tuberculosis (TB) treatment. Including DOTS (Directly Observed Treatment, Short-course) program, many programs for TB cases have yielded marginal success and the new drug resistance varieties of TB persist. During the 1960s, researchers have projected naphthoquinone-mercuric chloride (N-M) test as the single most way to objectively track the presence of isoniazid (INH) in urine and hence treatment adherence. INH is metabolised by cytochrome P450s and usually cleared from body within 8 h. Hence, the typical INH levels in biological fluids are within 1-5 μg/ml. The N-M test practically works at 10-50 μg/ml and the authors developed the sodium polyacrylate (SPA) as a solid surface to improve detection limit of INH by 6-10 fold. The modification involves absorbing the reagents of N-M test on the SPA surface and lyophilised material is directly used for diagnosis. The dry beads can detect 1-2 μg/ml of INH in saliva. The test performed with spiked as well as clinical samples and the results have good correlation. This new test has a realistic chance of tracking the TB treatment adherence remotely and in that direction a system was projected for implementation.

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Section: Introductionmentioning

confidence: 99%

Objective measurement of isoniazid levels: practical approach for monitoring tuberculosis drug treatment adherence

Korrapati

Muneppa

Pullela

et al. 2017

IET nanobiotechnol.

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“…In addition to rapid diagnosis and phenotyping, contact tracing and effective outbreak management are critical to controlling and preventing the spread of TB in settings where resources permit (60,61). Contact tracing is a routine epidemiological practice in which persons who may have been exposed to an infectious case of TB are identified, screened for evidence of LTBI or active TB, and offered preventative or active TB therapy when appropriate (1).…”

Section: Genomics As a Tool For Tb Outbreak Investigationmentioning

confidence: 99%

A Microbiological Revolution Meets an Ancient Disease: Improving the Management of Tuberculosis with Genomics

et al. 2015

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SUMMARY Tuberculosis (TB) is an ancient disease with an enormous global impact. Despite declining global incidence, the diagnosis, phenotyping, and epidemiological investigation of TB require significant clinical microbiology laboratory resources. Current methods for the detection and characterization of Mycobacterium tuberculosis consist of a series of laboratory tests varying in speed and performance, each of which yields incremental information about the disease. Since the sequencing of the first M. tuberculosis genome in 1998, genomic tools have aided in the diagnosis, treatment, and control of TB. Here we summarize genomics-based methods that are positioned to be introduced in the modern clinical TB laboratory, and we highlight how recent advances in genomics will improve the detection of antibiotic resistance-conferring mutations and the understanding of M. tuberculosis transmission dynamics and epidemiology. We imagine the future TB clinic as one that relies heavily on genomic interrogation of the M. tuberculosis isolate, allowing for more rapid diagnosis of TB and real-time monitoring of outbreak emergence.

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“…On the other hand, contact investigation focuses on identifying possible infection sources and understanding the conditions under which the transmission occurred. In the contemporary era, contact tracing and contact investigation effectively reduce the spread of infections like tuberculosis(ERKENS et al, 2010;SHRIVASTAVA;SHRIVASTAVA;RAMASAMY, 2014). These methods were also crucial in successfully containing the MERS outbreak 2013(MAILLES et al, 2013).In the recent COVID-19 pandemic, digital contact tracing systems have been introduced to identify potential transmission risks, offering an efficient alternative to traditional manual contact tracing techniques (ELMESALAWY; SALAMA; ANANY,…”

mentioning

confidence: 99%

Using location history data from cell phones of infectious patients for disease surveillance

Giddaluru

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reminder of how challenges ought to be tackled. Remembering my late father, Prasad Giddaluru, I am reminded of a man who never wavered in his commitment to my career growth despite the myriad obstacles he faced. His resilience in adversity has been a lesson in tenacity, perseverance, and devotion. I am eternally grateful to my family. I carry their teachings and affections with me, always! ABSTRACT GIDDALURU, J. Using location history data from cell phones of infectious patients for disease surveillance. 2023. Thesis (Doctorate) -

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Assessing the utility of contact tracing in reducing the magnitude of tuberculosis

Cited by 3 publications

References 8 publications

Objective measurement of isoniazid levels: practical approach for monitoring tuberculosis drug treatment adherence

Objective measurement of isoniazid levels: practical approach for monitoring tuberculosis drug treatment adherence

A Microbiological Revolution Meets an Ancient Disease: Improving the Management of Tuberculosis with Genomics

Using location history data from cell phones of infectious patients for disease surveillance

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