Compared with far-developed measures and methods for mono-specific forest stands, the silvicultural prescriptions for mixed-species stands are at their early beginning. However, they are essential for the well-conceived establishment, design, and control of mixed-species stands, currently promoted in many countries worldwide. Here, we review the state of the art and we further develop silvicultural prescriptions for mixed-species stands for steering of experiments, stand modeling, and silviculture. We review which aspects of tree species mixing are most relevant for management goal achievement. We found the maintenance of species diversity and structural heterogeneity for ecological purpose, stabilizing productivity, and social-economic performance as main objectives. We give an overview of quantitatively formulated silvicultural prescriptions for steering mixed-species stands for forest practice, long-term experiments, forest stand models. Compared with the sophisticated guidelines for mono-specific stands, prescriptions for mixed stand are often mainly qualitative and vague. Then, we introduce methodological approaches in development for steering mixture: measures for spatial and temporal separation, species-specific growing space requirements for crop trees, coefficients for equivalence and density modification, and basic relationships for steering tree number and area-based mixing proportions. Finally, we draw conclusions for further development of methodological approaches for silvicultural steering of experiments, implementation in stand simulators, and for silvicultural operations. We see the need for improving the quantitative spatially explicit rules based at tree or cohort level, for substantiating the knowledge on species-specific allometry, growing area, tree-to-tree distances, and position-dependent competition indices for steering tree removal. We discuss the prospects and limitations of establishing silvicultural prescriptions for mixed-species stands that inevitably will be more complicated than those for mono-specific stands, and we draw conclusions for next steps in science and practice.