Assessing Utilization of the Cerebrospinal Fluid Venereal Disease Research Laboratory Test for Diagnosis of Neurosyphilis: a Cohort Study

Sytsma, Terin T.; Theel, Elitza S.; Temesgan, Zelalem; Toledano, Michel

doi:10.1007/s11606-020-06127-z

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Antilipoidal antibodies are produced not only as a consequence of syphilis and other treponemal diseases but also in response to non-treponemal diseases of an acute and chronic nature in which tissue damage occurs ( 10 ). Although the incidence of biological false-positive VDRL tests is rare in spinal fluid samples ( 11 ), some studies have reported false-positive CSF VDRL results in the setting of central nervous system malignancy or HIV infection ( 12 – 14 ). However, for these syphilis patients, negative CSF-VDRL-10 results but positive CSF-VDRL-17 results may be indications for a very early phase of asymptomatic neurosyphilis and contribute to early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Which Is the Optimum Antigen Concentration for the Venereal Disease Research Laboratory Test of Cerebrospinal Fluid for Neurosyphilis Diagnosis: 10 or 17 μL?

Xiao

et al. 2022

Front. Med.

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The manufacturer's instructions for the venereal disease research laboratory (VDRL) antigen test for diagnosing neurosyphilis describe testing of serum samples and do not include procedures for cerebrospinal fluid (CSF) testing. This study compared the CSF-VDRL test with 10 μL of antigen (CSF-VDRL-10) according to the American Public Health Association to the CSF-VDRL test with 17 μL of antigen (CSF-VDRL-17) according to the VDRL serum procedure. A total of 121 neurosyphilis patients and 86 syphilis/non-neurosyphilis patients were included. The sensitivities of the CSF-VDRL-10 and CSF-VDRL-17 tests were comparable for neurosyphilis diagnosis. The positive rate of the CSF-VDRL-17 test was higher than that of the CSF-VDRL-10 test. In all, 78.3% of the quantitative CSF-VDRL-17 results were consistent with those of the CSF-VDRL-10 test, 18.4% exhibited one-titer higher results than those of the CSF-VDRL-10 test, and 3.4% had positive CSF-VDRL-17 results but negative CSF-VDRL-10 results. The CSF-VDRL test with 17 μL of antigen was more sensitive, and it is worth performing longitudinal studies to understand its practical implications.

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Section: Discussionmentioning

confidence: 99%

Which Is the Optimum Antigen Concentration for the Venereal Disease Research Laboratory Test of Cerebrospinal Fluid for Neurosyphilis Diagnosis: 10 or 17 μL?

Xiao

et al. 2022

Front. Med.

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The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients

Zhang,

et al. 2024

Sci Rep

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Abordagem Diagnóstica, Terapêutica e de Monitorização na Suspeita de Neurossífilis: Proposta de Protocolo Clínico

Martins,

Canelas,

Dias

et al. 2024

Acta Med Port

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O presente protocolo clínico foi desenhado para servir como um guia hospitalar na abordagem diagnóstica, terapêutica e de monitorização da neurossífilis, tendo em conta a positividade ou não para o vírus de imunodeficiência humana. A sífilis é uma doença sexualmente transmissível, de notificação obrigatória, conhecida como a grande imitadora nosológica. Em cerca de 30% dos casos de doença não tratada ocorre infeção persistente do sistema nervoso central. A neurossífilis é uma forma grave e progressiva de sífilis, que pode ocorrer em qualquer estádio da doença, com frequente atraso no diagnóstico e tratamento. Classifica-se como neurossífilis precoce (meningite sifilítica, neurossífilis meningovascular ou gomas sifilíticas) e neurossífilis tardia (gomas sifilíticas, demência sifilítica ou tabes dorsalis). A importância da punção lombar prende-se não só com questões diagnósticas, mas também com a avaliação da eficácia do tratamento. O tratamento desta patologia em todos os estádios consiste em penicilina por via parentérica. Com este protocolo pretende-se facilitar a decisão clínica nos casos de suspeita de neurossífilis através de uma conduta sistematizada, individualizada e multidisciplinar.

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Assessing Utilization of the Cerebrospinal Fluid Venereal Disease Research Laboratory Test for Diagnosis of Neurosyphilis: a Cohort Study

Cited by 3 publications

References 23 publications

Which Is the Optimum Antigen Concentration for the Venereal Disease Research Laboratory Test of Cerebrospinal Fluid for Neurosyphilis Diagnosis: 10 or 17 μL?

Which Is the Optimum Antigen Concentration for the Venereal Disease Research Laboratory Test of Cerebrospinal Fluid for Neurosyphilis Diagnosis: 10 or 17 μL?

The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients

Abordagem Diagnóstica, Terapêutica e de Monitorização na Suspeita de Neurossífilis: Proposta de Protocolo Clínico

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