Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion

Laškarin, Gordana; Gulić, Tamara; Gačanin, Lana Glavan; Dominović, Marin; Haller, Herman; Rukavina, Daniel

doi:10.1016/j.mehy.2018.04.008

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…In recent years, the research on the pathogenesis of delayed abortion has made great progress in the aspects of genetics, immunology, infection, and environment. Good formation of placental vascular network plays an extremely important role in fetal intrauterine development [ 6 ]. If the insufficient placental vascular dysplasia, perfusion, and placental microcirculation dysfunction can lead to placental insufficiency, placenta implantation dysfunction, maternal oxygen, nutrients, and immune factors cannot enter the fetal body through vascular network [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Expression and Relationship of Netrin‐1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion

Dong

Cao

Huang

et al. 2022

Contrast Media & Molecular Imaging

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In order to investigate the correlation between neuroaxon-guiding factor (Netrin-1), deleted in colorectal cancer (DCC), uncoordinated 5B (UNC5B), and vascular endothelial growth factor (VEGF) expression machine in villus tissues of delayed abortion in colorectal cancer, a total of 120 pregnant women are selected from February 2019 to August 2021. The two groups of subjects improve the relevant examinations before surgery and the underwent negative pressure induces abortion hysterectomy guided by abdominal ultrasound under intravenous anesthesia. The mRNA and protein expressions of netrin-1, DCC, UNC5B, and VEGF in the villi of the two groups are detected by real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC), and the correlation of the four indicators is analyzed by Pearson's test.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Expression and Relationship of Netrin‐1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion

Dong

Cao

Huang

et al. 2022

Contrast Media & Molecular Imaging

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“…Progesterone inhibited cDCs' ability to induce NK cell proliferation and secrete IL-15, resulting in human abortion. It was hypothesized that progesterone-shaped DCs cannot efficiently multiply or equip NK cells with the cytotoxic mediators perforin and granulysin during DC/NK cell interaction, which may harm trophoblasts and induce abortion (Laskarin et al 2018). However, in DBA/2 J-mated CBA/J abortion-prone mice, a substantial rise in the uterine Treg cell pool was induced by progesterone administration, and the rate of abortion was unaffected.…”

Section: Dcs In Rsa and Implantation Failurementioning

confidence: 99%

Dendritic Cells and the Establishment of Fetomaternal Tolerance for Successful Human Pregnancy

Mahajan,

Kumar,

Rath

et al. 2024

Archivum Immunologiae Et Therapiae Experimentalis

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Pregnancy is a remarkable event where the semi-allogeneic fetus develops in the mother’s uterus, despite genetic and immunological differences. The antigen handling and processing at the maternal–fetal interface during pregnancy appear to be crucial for the adaptation of the maternal immune system and for tolerance to the developing fetus and placenta. Maternal antigen-presenting cells (APCs), such as macrophages (Mφs) and dendritic cells (DCs), are present at the maternal–fetal interface throughout pregnancy and are believed to play a crucial role in this process. Despite numerous studies focusing on the significance of Mφs, there is limited knowledge regarding the contribution of DCs in fetomaternal tolerance during pregnancy, making it a relatively new and growing field of research. This review focuses on how the behavior of DCs at the maternal–fetal interface adapts to pregnancy’s unique demands. Moreover, it discusses how DCs interact with other cells in the decidual leukocyte network to regulate uterine and placental homeostasis and the local maternal immune responses to the fetus. The review particularly examines the different cell lineages of DCs with specific surface markers, which have not been critically reviewed in previous publications. Additionally, it emphasizes the impact that even minor disruptions in DC functions can have on pregnancy-related complications and proposes further research into the potential therapeutic benefits of targeting DCs to manage these complications.

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Dendritic cells in pregnancy and pregnancy-associated diseases

Wei

Lai

Zhao

et al. 2021

Biomedicine & Pharmacotherapy

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Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion

Cited by 3 publications

References 39 publications

[Retracted] Expression and Relationship of Netrin‐1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion

[Retracted] Expression and Relationship of Netrin‐1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion

Dendritic Cells and the Establishment of Fetomaternal Tolerance for Successful Human Pregnancy

Dendritic cells in pregnancy and pregnancy-associated diseases

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