Assessment and Optimisation of Lung Cancer Patients for Treatment with Curative Intent

Harris, Christopher; Meek, David; Gilligan, David; Williams, Lynne; Solli, Piergiorgio; Rintoul, Robert C.

doi:10.1016/j.clon.2016.08.002

Cited by 4 publications

(3 citation statements)

References 99 publications

(97 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, simultaneous bilateral VATS has been confirmed as both feasible and safe, and may serve as a surgical option that would overcome the challenges faced by patients with BSMPLA. In our study, therefore, we deemed it necessary to assess each patient's fitness for surgical treatment, using parameters such as age, performance status, cardiovascular evaluation, basic spirometry and diffusion capacity, and predicted postoperative lung function (12). Additionally, we considered the wishes of patients and their families as essential to decisions regarding simultaneous bilateral VATS.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of 56 cases of simultaneous bilateral video-assisted thoracoscopic surgery for bilateral synchronous multiple primary lung adenocarcinoma

Zhang¹,

Wang²,

Lv³

et al. 2018

J. Thorac. Dis

View full text Add to dashboard Cite

Background: Bilateral synchronous multiple primary lung adenocarcinoma (BSMPLA) is a rapidly increasing disease for which timely and accurate treatment is required. We describe our experience which we hope to establish optimal therapeutic options for patients with BSMPLA. Methods: This study aimed to explore the feasibility and safety of simultaneous bilateral video-assisted thoracoscopic surgery (VATS) in 56 patients who received histological diagnoses of BSMPLA at our hospital between January 2016 and January 2018. In this retrospective analysis of clinical outcomes, we observed no serious postoperative complications or perioperative death. Results: Four and 28 patients respectively underwent bilateral lobectomy and lobectomy with contralateral sublobar resection, whereas the remaining 24 patients underwent bilateral sublobar resection. Sublobar resection means anatomical segmentectomy or wedge resection. The mean postoperative hospital stay duration was 5.39±2.67 days. Postoperative complications comprising persistent air leakage for more than 5 days was observed in 8 (14.2%) of 56 patients. No severe postoperative complications or deaths occurred. Conclusions: Our results suggest that simultaneous bilateral VATS is feasible, safe, and reproducible. This therapeutic strategy appears to confer considerable benefits on patients with BSMPLA.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical analysis of 56 cases of simultaneous bilateral video-assisted thoracoscopic surgery for bilateral synchronous multiple primary lung adenocarcinoma

Zhang¹,

Wang²,

Lv³

et al. 2018

J. Thorac. Dis

View full text Add to dashboard Cite

show abstract

“…that indicates operability. The determination of the patient's general condition using the ECOG scale or the Karnofsky index as well as their expectations and socio-family environment will help to make individualised decisions regarding the surgical options [112,113].…”

Section: Surgical Treatment Of Stage III Nsclcmentioning

confidence: 99%

Multidisciplinary consensus statement on the clinical management of patients with stage III non-small cell lung cancer

et al. 2019

View full text Add to dashboard Cite

Stage III non-small cell lung cancer (NSCLC) is a very heterogeneous disease that encompasses patients with resected, potentially resectable and unresectable tumours. To improve the prognostic capacity of the TNM classification, it has been agreed to divide stage III into sub-stages IIIA, IIIB and IIIC that have very different 5-year survival rates (36, 26 and 13%, respectively). Currently, it is considered that both staging and optimal treatment of stage III NSCLC requires the joint work of a multidisciplinary team of expert physicians within the tumour committee. To improve the care of patients with stage III NSCLC, different scientific societies involved in the diagnosis and treatment of this disease have agreed to issue a series of recommendations that can contribute to homogenise the management of this disease, and ultimately to improve patient care.

show abstract

“… 4 , 5 Surgery is the mainstay treatment for patients with NSCLC. 6 – 8 Since the first case of video-assisted thoracic surgery lobectomy (VATS) treatment for NSCLC in 1992, 9 studies have shown that compared with open surgery, VATS treatment of early stage NSCLC resulted in less blood loss, faster postoperative recovery, less trauma, similar or reduced postoperative complications, and similar long-term outcomes. 10 – 22 VATS has gradually been applied in the treatment of locally advanced NSCLC (LA-NSCLC), due to accumulation of experience and continuous improvement of surgical instruments.…”

Section: Introductionmentioning

confidence: 99%

Short- and long-term outcomes in elderly patients with locally advanced non-small-cell lung cancer treated using video-assisted thoracic surgery lobectomy

Zhang

2018

TCRM

View full text Add to dashboard Cite

BackgroundIn recent years, video-assisted thoracic surgery (VATS) lobectomy has been used to treat locally advanced non-small-cell lung cancer (LA-NSCLC). However, VATS has not been reported in elderly patients (≥70 years) with LA-NSCLC. The purpose of this study was to compare short- and long-term outcomes of patients with LA-NSCLC aged ≥70 years and 55–69 years treated with VATS.Patients and methodsFrom January 2012 to January 2018, a total of 83 patients with LA-NSCLC who were ≥55 years of age underwent VATS. Patients were divided into ≥70 years group (37 cases) and 55–69 years group (46 cases), based on their age at the time of VATS. Short- and long-term outcomes of these two groups of patients were compared.ResultsAmerican Society of Anesthesiologists scores of ≥70 years patients were higher than those of 55–69 years patients. No significant differences were observed when comparing the general preoperative data. For short-term outcomes, there was no significant difference between the two groups of patients in length of surgery, intraoperative blood loss, conversion to thoracotomy, postoperative 30-day complication rate and severity, postoperative 30-day mortality, pathological results, compliance with adjuvant chemotherapy, or other factors. Long-term follow-up results showed that recurrence, overall survival, and disease-free survival were similar in both groups. Furthermore, multivariate analysis showed that age was not an independent predictor of overall and disease-free survival.ConclusionsVATS in elderly patients (≥70 years) with LA-NSCLC can result in short- and long-term outcomes similar to those of 55–69 years patients with LA-NSCLC.

show abstract

Assessment and Optimisation of Lung Cancer Patients for Treatment with Curative Intent

Cited by 4 publications

References 99 publications

Clinical analysis of 56 cases of simultaneous bilateral video-assisted thoracoscopic surgery for bilateral synchronous multiple primary lung adenocarcinoma

Clinical analysis of 56 cases of simultaneous bilateral video-assisted thoracoscopic surgery for bilateral synchronous multiple primary lung adenocarcinoma

Multidisciplinary consensus statement on the clinical management of patients with stage III non-small cell lung cancer

Short- and long-term outcomes in elderly patients with locally advanced non-small-cell lung cancer treated using video-assisted thoracic surgery lobectomy

Contact Info

Product

Resources

About