Assessment in vitro of radioprotective efficacy of curcumin and resveratrol

Sebastià, Natividad; Montoro, Alegría; Montoro, A Fullana; Almonacid, M.; Villaescusa, J. I.; Cervera, José; Such, Esperanza; Silla, Ma Angeles; Castillo, José Miguel Soriano del

doi:10.1016/j.radmeas.2011.05.009

Cited by 38 publications

(30 citation statements)

References 25 publications

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“…A higher level of t ‐resveratrol from seed (5.6 mg 100 g −1 ) was obtained with MAATPE, while a lower quantity of this compound (0.2 mg 100 g −1 ) was obtained with ATPE. Resveratrol health benefits include free radical scavenging as well as anti‐inflammatory and anti‐proliferative properties…”

Section: Resultsmentioning

confidence: 99%

Microwave‐assisted aqueous two‐phase extraction of phenolics from grape (Vitis vinifera) seed

Dang

Zhang

Xiu

2013

J of Chemical Tech & Biotech

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BACKGROUND The wine making process produces a large quantity of grape marc, which includes grape seeds, skins, and stems. These byproducts comprise approximately 20% of the harvested grapes. Aqueous two‐phase extraction (ATPE) composed of short‐chain alcohol, inorganic salt, and water is a novel approach used to separate active constituents from fermentation broth or natural plant. A microwave‐assisted aqueous two‐phase extraction (MAATPE) method was used to obtain phenolic compounds from grape seeds. The partitioning behavior of the phenolic compounds in the MAATPE system was assessed. RESULTS Phenolic compounds were extracted into the top acetone‐rich phase at 32% (w/w) acetone/16% (w/w) ammonium citrate. The maximum yield of total phenolics, flavonoid, and proanthocyanidin were 82.7, 52.6, and 30.7 mg g−1, respectively. The corresponding recovery rates were 97.1%, 97.9%, and 99.3%. The antioxidant activity of seed extracts was determined by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonate) (ABTS) radical‐scavenging ability (IC50). No significant correlation was found between free radical scavenging capacity and TP content. CONCLUSION MAATPE required lower solvent concentration and less treatment time to extract high amounts of phenolics from grape seeds compared with the other methods. MAATPE has the potential for the extraction, clarification, and concentration of target products using a single step. © 2013 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Microwave‐assisted aqueous two‐phase extraction of phenolics from grape (Vitis vinifera) seed

Dang

Zhang

Xiu

2013

J of Chemical Tech & Biotech

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“…Also, modulation of intracellular redox state is an indirect mechanism since several critical transcription factors control cell cycle, differentiation, stress response and other physiological processes [19][20][21][22][23]. Curcumin has also been shown to potentiate the effect of chemotherapeutic agents [21] and of c-radiation [22] in cell culture, and capsaicin is able to trigger apoptosis in human cancer cells, and a direct inhibitory effect of tumour growth has been observed [19,23].…”

Section: Introductionmentioning

confidence: 99%

Guaicolic spices curcumin and capsaicin electrochemical oxidation behaviour at a glassy carbon electrode

Manaia

Diculescu

Gil

et al. 2012

Journal of Electroanalytical Chemistry

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“…[7,10] The cell killing by DMSO may thus involve either production of free radicals or H 2 O 2 ,which can be taken care of by curcumin as reported by others. [7,10,12] A preliminary study in our laboratory revealed that DMSO is a weak inducer of genotoxicity in WP2s cells (unpublished data). The damage induced in the DNA of E. coli WP2s may be due to the formation of free radicals on exposure of the cells to DMSO.…”

Section: Discussionmentioning

confidence: 99%

“…A detailed study on this may lead to interesting results. Protection by curcumin against chemical-induced toxicity both in vitro [7,12] and in vivo [13] has already been reported. The extensively used organic solvent,namely, DMSO was found to induce toxicity in WP2s cells and that curcumin and all the curcuminoids contained in it are found to impart protection individually against the toxicity induced by this agent in the said cells.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity of curcumin in a bacterial system

Pal¹,

Ghosh²,

Pal³

2013

J Nat Pharm

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Background: Curcumin, believed to be the main bioactive component of turmeric is well-known for its antioxidant, radio-protective, radical-scavenging, and anticancer properties. Commercially available curcumin, found to be composed of at least three different compounds have been employed for their individual biological activity vis-a-vis curcumin as a whole in a bacterial system. Materials and Methods: Commercially available curcumin has been subjected to a round of High performance thin layer chromatography (HPTLC) analysis and their biological activities have been monitored by survival studies in Escherichia coli cells. Results: Curcumin as well as the individual components in it has been found to impart some sort of protection against the toxicity imparted by its delivering solvent namely DMSO. Conclusions: The degree of protection induced by curcumin and all the individual components in it has been discussed in relation to the relative proportions of the individual components present in curcumin.

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Assessment in vitro of radioprotective efficacy of curcumin and resveratrol

Cited by 38 publications

References 25 publications

Microwave‐assisted aqueous two‐phase extraction of phenolics from grape (Vitis vinifera) seed

Microwave‐assisted aqueous two‐phase extraction of phenolics from grape (Vitis vinifera) seed

Guaicolic spices curcumin and capsaicin electrochemical oxidation behaviour at a glassy carbon electrode

Bioactivity of curcumin in a bacterial system

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