Assessment of a point‐of‐care cardiac troponin I test to differentiate cardiac from noncardiac causes of respiratory distress in dogs

Abstract

cTnI concentrations were significantly increased in dogs with cardiogenic respiratory distress versus dogs with noncardiogenic respiratory distress and normal dogs. A significant difference between normal dogs and dogs with noncardiogenic causes of respiratory distress was detected. Although highly sensitive when cTnI concentrations exceed 1.5 ng/mL, the test has low specificity. Assessment of cTnI by the methodology used cannot be recommended as the sole diagnostic modality for evaluating the cause of respiratory distress in dogs.

Biologic variability in NT‐proBNP and cardiac troponin‐I in healthy dogs and dogs with mitral valve degeneration

“…For instance C‐TnI concentrations have high specificity and sensitivity for differentiation between normal individuals and patients with myocardial disease . A point‐of‐care C‐TnI determination has been reported to distinguish between cardiogenic and noncardiogenic causes of dyspnea in dogs, with dogs presenting with noncardiogenic dyspnea showing a median C‐TnI concentration of 0.14 ng/mL vs 1.74 ng/mL in dogs with cardiac disease . With such high magnitudes of change in analyte concentration in diseased individuals, the degree of longitudinal biologic variation becomes less important when using a test to diagnose disease.…”

Association between cardiac troponin I concentrations and electrocardiographic abnormalities in dogs with blunt trauma

“…A cTnI concentration was performed on entry using approximately 0.1 mL of whole blood or heparinized plasma that was saved from the initial blood collection for measurement of PCV, TPP, BG, and PL (all included in the emergency exam fee and performed on every emergency case that enters the hospital). The cTnI concentration was performed using a veterinary point‐of‐care assay * that has been used previously in canine studies 8–11 . This assay has a reported range of 0.00–50.00 ng/mL.…”

“…For the statistical purposes of this study, a reading of >50.00 ng/mL was recorded as 50.00 ng/mL. The reported reference range of 0–0.11 ng/mL for normal dogs was used in this study 8,9 …”

Troponina, biomarcador de injuria cardiaca, en medicina veterinaria: Revisión

“…Conolli et al (2009) Diferentemente dos felinos, em cães foi possível confirmar a origem cardíaca da desordem respiratória com o uso da cTnI (Payne et al, 2011). No entanto, em ambas as espécies os autores recomendaram a associação com outros métodos diagnósticos para a confirmação da etiologia primária.…”

“…No entanto, em ambas as espécies os autores recomendaram a associação com outros métodos diagnósticos para a confirmação da etiologia primária. Ressalta-se que, em humanos são realizadas dosagens seriadas, se após um intervalo de 10 horas seu o nível sérico diminui associa se a dispneia de origem não cardíaca, direcionando assim o tratamento inicial de forma adequada evitando complicações pelo uso incorreto da terapêutica (Martins, 2009, Payne et al, 2011.…”