Assessment of a scoring system for Basal Cell Carcinoma with multi‐beam optical coherence tomography

Wahrlich, Caroline; Alawi, Seyed Arash; Batz, Sebastian; Fluhr, Joachim W.; Lademann, Jürgen; Ulrich, Martina

doi:10.1111/jdv.12935

Cited by 40 publications

(45 citation statements)

References 40 publications

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“…In view of the fact that the incidence of NMSC types has continuously increased in the past decades, several studies have already been performed to investigate the applicability of OCT and early detection of these diseases by means of OCT and create standard detection criteria [1, 2, 18-22, 24, 25]. In the so-called “Berlin Score,” for instance, the focus was primarily placed on recurring OCT characteristics of BCC and their subtypes to investigate a possible correlation and its practical application to, and usefulness in, clinical routine [18].…”

Section: Methodsmentioning

confidence: 99%

“…All characteristics were established based on clinical OCT experience and in close cooperation with dermatologists, students, and histopathologists. Other criteria such as parakeratosis, acanthosis, and occurrence of hyperreflective nests were analyzed besides the criteria established in the Berlin Score (e.g., noncompressible dark borders, ovoid structures, and hyporeflective nests) [18]. Similar to the Berlin Score all subtypes of BCC were included (e.g., nodular, micronodular, cystic BCC, etc.).…”

Section: Methodsmentioning

confidence: 99%

“…OCT is a noninvasive, cross-sectional, real-time technique based on Michelson interferometry that is used to examine all kinds of benign and malignant skin diseases [18]. The lateral optical resolution is approximately 7.5 µm and the axial resolution is approximately < 10 µm.…”

Section: Methodsmentioning

confidence: 99%

“…In the so-called “Berlin Score,” for instance, the focus was primarily placed on recurring OCT characteristics of BCC and their subtypes to investigate a possible correlation and its practical application to, and usefulness in, clinical routine [18]. In this study, similar characteristics were used as in previous studies [18] with regard to 5 different tumor entities, i.e., BCC, sBCC, AK, Bowen disease, and squamous cell carcinoma (SCC), to investigate any existing correlations. All characteristics were established based on clinical OCT experience and in close cooperation with dermatologists, students, and histopathologists.…”

Section: Methodsmentioning

confidence: 99%

“…However, the greatest and most sophisticated challenge is to investigate the applicability of OCT in NMSC diagnosis. Several studies have already been dedicated to the topic of creating standard detection criteria for the different NMSC types [2, 18-23]. Such standard criteria have successfully been defined for actinic keratosis (AK) as well as basal cell carcinoma (BCC), but they have turned out to be rather difficult to determine for the other tumor entities.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT

Batz

Wahrlich

Alawi

et al. 2018

Skin Pharmacol Physiol

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Background: Early detection of various types of nonmelanoma skin cancer has been a challenge in dermatology. Noninvasive examination procedures such as optical coherence tomography (OCT) play an increasingly important role, besides the established gold standard of histological tissue sample analysis. OCT is a noninvasive, cross-sectional, real-time technique that allows conclusions to be drawn with regard to the presence of pathologies. Objective: The objective of this study was to investigate whether it is possible to distinguish between different types of nonmelanoma skin cancer using OCT or not. Methods: A study population of a total of 25 cases, comprising 5 cases, each, of 5 tumor entities (i.e., basal cell carcinoma, superficial basal cell carcinoma, actinic keratosis, squamous cell carcinoma, and Bowen disease) was examined. Relevant lesions were scanned both centrally and peripherally in the multislice mode. All OCT images were blinded, randomized, analyzed, and evaluated by 2 clinicians experienced in OCT. Results: This study demonstrated that it is possible to determine correlations between various types of tumors and recurring tumor characteristics. Conclusion: This study showed that it is possible to distinguish between the different nonmelanoma skin cancers by using OCT, but further prospective studies have to be conducted to validate the sensitivity and specificity of the criteria.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT

Batz

Wahrlich

Alawi

et al. 2018

Skin Pharmacol Physiol

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Optical coherence tomography for diagnosing skin cancer in adults

Ruffano

Dinnes

Deeks

et al. 2018

Cochrane Database of Systematic Reviews

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Background Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Optical coherence tomography (OCT) is a microscopic imaging technique, which magnifies the surface of a skin lesion using near-infrared light. Used in conjunction with clinical or dermoscopic examination of suspected skin cancer, or both, OCT may offer additional diagnostic information compared to other technologies. Objectives To determine the diagnostic accuracy of OCT for the detection of cutaneous invasive melanoma and atypical intraepidermal melanocytic variants, basal cell carcinoma (BCC), or cutaneous squamous cell carcinoma (cSCC) in adults.

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Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography—A pilot study

Israelsen

Mogensen

Jensen

et al. 2021

Journal of Biophotonics

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Bedside diagnosis of skin cancer remains a challenging task. The real-time noninvasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results.

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Assessment of a scoring system for Basal Cell Carcinoma with multi‐beam optical coherence tomography

Cited by 40 publications

References 40 publications

Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT

Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT

Optical coherence tomography for diagnosing skin cancer in adults

Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography—A pilot study

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