Assessment of Acute complications and Quality of Life in Hemodialysis patients with Chronic Kidney Disease

Background Despite the growing concern worldwide regarding the quality of life (QoL) and mental well-being among chronic kidney disease (CKD), a few research has been done to address this issue. The study aims to measure depression, anxiety, and QoL prevalence among Jordanian patients with End Stage Renal Disease (ESRD) on hemodialysis and how all of these variables are correlated. Methods This is a cross-sectional, interview-based study on patients at the Jordan University Hospital (JUH) dialysis unit. Sociodemographic factors were collected, and the prevalence of depression, anxiety disorder, and QOL was assessed using the Patient Health Questionnaire 9 (PHQ9), the Generalized Anxiety Disorder 7-item (GAD7), and the WHOQOL-BREF, respectively. Results In a study of 66 patients, 92.4% had depression, and 83.3% had generalised anxiety disorder. Females had significantly higher depression scores than males (mean = 6.2 ± 3.77 vs 2.9 ± 2.8, p < 0.001), and single patients had significantly higher anxiety scores than married patients (mean = 6.1 ± 6 vs 2.9 ± 3.5, p = 0.03). Age was positively correlated with depression scores (rs= 0.269, p = 0.03), and QOL domains showed an indirect correlation with GAD7 and PHQ9 scores. Males had higher physical functioning scores than females (mean = 64.82 vs 58.87, p = 0.016), and patients who studied in universities had higher physical functioning scores than those with only school education (mean of College/University = 78.81 vs mean of School Education = 66.46, p = 0.046). Patients taking <5 medications had higher scores in the environmental domain (p = 0.025). Conclusion The high prevalence of depression, GAD, and low QOL in ESRD patients on dialysis highlights the need for caregivers to provide psychological support and counselling for these patients and their families. This can promote psychological health and prevent the onset of psychological disorders.

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“… 44 However, some studies have not found any association between marital status with anxiety, depression, or QOL. 26 , 43 , 44 , 47 , 48 …”

Section: Discussionmentioning

confidence: 99%

Level of Depression and Anxiety on Quality of Life Among Patients Undergoing Hemodialysis

Alshelleh¹,

Alhawari²,

Alhouri³

et al. 2023

IJGM

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“…1,2,3 This rise has been paralleled by an increase in metabolic syndrome, a condition that heightens the risk of mortality from chronic kidney disease (CKD), as reported by LaGuardia HA et al 4 CKD, characterized by a gradual and progressive loss of renal function over at least three months, is a primary cause of end-stage renal disease (ESRD). 5 The global prevalence of CKD ranges from 8-16%, varying across different regions. 6 CKD is categorized into ve stages based on the degree of kidney damage or the estimated glomerular ltration rate (eGFR).…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Regrettably, the majority of patients remain unaware of their condition until it has advanced to a later stage. 9 Early cardiovascular disease (CVD), anemia, metabolic acidosis, and bone diseases are among the major complications associated with impaired kidney function. 10 The leading risk factors and predictors for CKD include impaired fasting plasma glucose, hypertension, and a high body mass index (BMI).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome among middle-aged patients and its association with chronic kidney disease: A Cross-sectional study

2024

Preprint

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Background Previous surveys suggest that obesity, hypertension, and diabetes mellitus may be positively related to the development of chronic kidney disease (CKD). However, this association might be altered by metabolic syndrome. Chronic kidney disease has become a worldwide health problem among aging populations. Hence, epidemiological information on middle-aged patients with metabolic syndrome is still lacking. Objectives The study aimed to assess the prevalence of metabolic syndrome among middle-aged patients and its association with chronic kidney disease. Methodology: The hospital-based cross-sectional study was carried out on 317 participants aged 40–59 years. All participants received a standardized personal interview, including a structured questionnaire, anthropometric measurements, and blood samples collected for laboratory testing. Metabolic syndrome was identified based on the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III). The estimated glomerular filtration rate (eGFR) was calculated by using the Cockroft-Gault formula, which in turn is utilized to predict the stages of chronic kidney disease based on the eGFR range based on NKF-KDOQI. Result and discussion: We investigated the association between metabolic syndrome and chronic kidney disease (CKD) in 317 participants aged 40-59 years. We found that metabolic syndrome was prevalent in more than half of the participants (54.2%) and increased with the worsening of CKD stages. We also identified waist circumference, fasting blood sugar, and triglycerides as significant metabolic factors associated with CKD. Furthermore, we observed that longer durations of diabetes mellitus and hypertension, especially when combined, increased the risk of CKD. Conclusion: Our findings suggest that metabolic syndrome is a major contributor to CKD and that early detection and management of metabolic factors are essential to prevent kidney damage.

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Biochemical Study on Fibroblast growth factor 23(FGF23) and its relation with Chronic Kidney Disease

Ahmed

Younis

2023

RJPT

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The research involved study the relation between FGF23 and some of the biochemical parameters related to the chronic kidney disease(phosphate, vitamin D, calcium, urea, creatinine, chloride, potassium, albumin, alkaline phosphatase enzyme (ALP), transamination enzymes GOT and GPT)in serum blood patients compared with control group, the result demonstration is a significant increase in the mean concentration rate FGF23(324.06± 291.1pg/ml) in patients compared with mean concentration in control group was ( 273±188.5pg/ml), also the result showed a significant increase in the concentration of (phosphate, urea, creatinine, potassium, ALP) and a significant decrease had been shown in the concentration of (vitamin D, calcium, albumin, GOT and GPT enzymes). while the results had been showed a non-significant increase in chloride in patients compared with control group, Correlation coefficient of FGF23 with these clinical parameters showed a negative significant correlation with( phosphate, vitamin D, Albumin) while FGF23 elucidated a positive significant correlation with calcium while the result showed a non-significant correlation with rest of the biochemical parameters, conclusion of this study was that FGF23 concentration correlated significantly in hyperphosphatemia, decrease vitamin D and calcium in chronic kidney disease CKD.

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Assessment of Acute complications and Quality of Life in Hemodialysis patients with Chronic Kidney Disease

Cited by 8 publications

References 15 publications

Level of Depression and Anxiety on Quality of Life Among Patients Undergoing Hemodialysis

Level of Depression and Anxiety on Quality of Life Among Patients Undergoing Hemodialysis

Prevalence of Metabolic Syndrome among middle-aged patients and its association with chronic kidney disease: A Cross-sectional study

Biochemical Study on Fibroblast growth factor 23(FGF23) and its relation with Chronic Kidney Disease

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