Assessment of acute toxicity profile of Lasianthera africana leaf extract in normal rats and its ameliorative effect in alloxan-induced diabetic rats

Abstract

The present study evaluated the acute toxicity effect of Lasianthera africana leaf extract on normal rats and effect of the extract on the hepatic and renal function indices in alloxan-induced diabetic rats. In the acute toxicity test, male Wister rats received orally four different single dose of the extract and were kept under observation for 14 days. The result indicates that LD 50 of the extract is higher than 5,000 mg/kg body weight. For the second experiment, doses (50, 100 and 200 mg/kg body weight) of the leaf extract were administered orally to alloxan-induced diabetic rats for 28 days and the effect of the treatment on blood glucose, hepatic enzymes, serum proteins and renal function indices was evaluated. The result indicates progressive and significant (p>0.05) reduction in fasting blood glucose. The extract also exhibited significant (p<0.05) reduction in serum aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), and significant (p<0.05) increase in serum total proteins and globulin and marginal (p>0.05) reduction in serum creatinine and uric acid relative to the diabetic control group. The results suggest that the leaf extract is safe and may be beneficial in the management of diabetic mellitus.

WITHDRAWN: Production of Acarbose From Actinoplanes Species Isolated From Termite Mound for Treatment of Type Two Diabetes

“…The reduction in leukocyte counts when treating diabetic rats with both commercial and laboratory-produced acarbose may be due to the anti-inflammatory, antioxidant, and free radical scavenging activities of it. This agrees with Baba et al (2018. The other effects of chronic hyperglycemia mentioned above may have been counteracted by the hypoglycemic effect of the leaves (Inyang et al, 2015).…”

WITHDRAWN: Production of Acarbose From Actinoplanes Species Isolated From Termite Mound for Treatment of Type Two Diabetes

“…al., 2018. The other effects of chronic hyperglycemia mentioned above may have been counteracted by the hypoglycemic effect of the leaves (Inyang, et al, 2015).…”

Effect of ethanol extract of the fruiting bodies of organically cultivated <i>Pleurotusostreatus</i> on the haematological indices of high sucrose- high fat diet-streptozotocin induced diabetic rats

“…The reduction in WBC count upon treatment of diabetic rats with the mushroom extracts may be attributable to its ant-inflammatory action (Okokon et al, 2013), antioxidant effect (Atiko et al,2016 and free radical scavenging activity ( Baba et al, 2018). The other effects of chronic hyperglycemia mentioned above may have been countered by the hypoglycemic effect of the mushroom (Inyang et al,2015). The results from this study therefore reveals that extracts from Pleurotusostreatus samples may be used to improve immune function against infection.…”

“…Since hyperglycemia is behind the activation (Papatheodorou et al, 2018), the mushroom extract may have produced the observed effects through reduction in blood glucose since it has hypoglycemic activity (Inyang et al, 2015).…”