Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Akyürek, Fatma Tunçez; Kurtipek, Gülcan Saylam; Kurku, Hüseyin; Akyürek, Fıkret; Ünlü, Ali; Abuşoğlu, Sedat; Ataseven, Arzu

doi:10.1111/jocd.13590

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…They also found that IMA plasma levels increased with disease severity. As the disease progresses, plasma levels of L-arginine, citrulline and vitamin A decrease [38]. According to all these studies, our results show that AV patients have higher IMA levels.…”

supporting

confidence: 70%

Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris

Balık,

Fırat Oğuz

et al. 2023

Dermatol Pract Concept

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Introduction: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers. Objectives: In this study, it was aimed to evaluate the blood levels of thiols and IMA, which are accepted as oxidative stress markers, and to determine the severity of the disease in AV patients whose severity is determined by the global acne score rate (GAS). Methods: Thiol parameters and IMA values were measured spectrophotometrically in blood samples taken from patients and controls. Determine VAS values in AV patients. The thiol and IMA values obtained were compared between the patient and control groups and their correlation with the patient's VAS values was evaluated. Results: In our study, in acne patients, native thiol (NT), total thiol (TT) and index 3 (I3=NT/TT*100) were significantly lower than the control group, disulfide (SS), index 1 (I1=SS/NT*100), index 2 (I2=SS/TT*100) and IMA values were found to be significantly higher. GAS values, which are accepted as an indicator of the degree and severity of acne disease, and SS, I1 and I2 showed a positive correlation, while I3 showed a negative correlation. Conclusion: Our study suggests that oxidative stress associated with AV disease pathogenesis may occur through mechanisms dependent on thiol and IMA levels. Therefore, in AV, oral supplementation or topical application of antioxidants may be a good way to increase drug efficacy or prevent potential harm.

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supporting

confidence: 70%

Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris

Balık,

Fırat Oğuz

et al. 2023

Dermatol Pract Concept

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“…The role of factors such as diet, vitamin D, autoinflammation, obesity, and some biochemical parameters appears to be involved in acne vulgaris 18,19 . A study declared that L‐arginine‐NO, oxidative stress, and ischemia‐modified albumin (IMA) may play a significant role in the progression and pathogenesis of acne vulgaris 20 . The role of survivin in maintaining the viability of epidermal stem cells has been suggested in the past decades.…”

Section: Discussionmentioning

confidence: 99%

Elevated survivin levels in patients with acne vulgaris

Saraç

Kader²,

Akdağ

2022

J of Cosmetic Dermatology

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Objective Acne vulgaris is a multifactorial disease of the pilosebaceous unit. As the most common skin disease, it may affect approximately 85% of the young population. Survivin, a member of the inhibitors of the apoptosis (IAP) gene family, can inhibit apoptosis and regulate cell division and proliferation. In the study, we aimed to investigate the potential role of serum survivin in acne vulgaris. Methods Forty individuals who were diagnosed with acne vulgaris and forty healthy subjects as the control group were enrolled in the study. Venous blood samples were collected from each participant, and the serum levels of survivin were measured by enzyme‐linked immunosorbent assay (ELISA). Statistical analysis was performed using SPSS software version 25. Results The serum survivin levels were statistically significant between the groups, and the levels of survivin were measured as acne vulgaris patients group 153.44 and control group 104.17 pg/ml, respectively (p < 0.018). When the serum survivin levels were compared according to gender, females had higher levels of survivin than the males (168.16 versus 50.45 pg/mL, p = 0.001). A significant correlation was found between acne severity (p = 0.017) and Scale for Acne Scar severity (SCAR‐S) score (p = 0.001) according to the survivin levels. In terms of age, no significant relationship was found between age and survivin (p = 0.4048). Conclusion Elevated serum levels of survivin were determined in acne vulgaris. Moreover, there was a significant correlation between acne stage and SCAR‐S score according to survivin levels.

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“…Under OS conditions, there is an increase in the activity of enzymes responsible for the generation of SDMA and ADMA as well as a decrease in the activity of enzymes involved in their metabolism [89]. The only study that assessed SDMA and ADMA levels in acne patients revealed higher serum levels of these compounds [55].…”

Section: Oxidative Stress Markers Evaluated In Acne Patientsmentioning

confidence: 99%

Markers of Oxidative Stress in Patients with Acne: A Literature Review

Popa

Mitran

et al. 2023

Life

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Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis is multifactorial and involves the overlap between four main processes: alteration of the keratinization, increased sebum production, colonization with Cutibacterium acnes, and inflammation. The role of oxidative stress (OS) has been intensively studied in inflammatory skin conditions such as psoriasis, vitiligo, or atopic dermatitis. However, the involvement of OS in the pathogenesis of acne is less known. The evidence accumulated over the last decade suggests that in the case of acne patients, there is an imbalance between oxidants and antioxidants. In this review, we analyzed studies that evaluated markers of OS in patients with acne, published in the last ten years, with the aim of providing new insights into the pathogenesis of acne.

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Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Cited by 10 publications

References 25 publications

Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris

Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris

Elevated survivin levels in patients with acne vulgaris

Markers of Oxidative Stress in Patients with Acne: A Literature Review

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