Introduction: Psoriasis is a common, inflammatory skin disease of which etiopathogenesis is still not explained clearly, however in which trace elements and oxidative stress are considered to play a role. Aim: To evaluate the serum trace element and oxidative stress levels in patients diagnosed with psoriasis. Material and methods: A total of 87 psoriasis patients and 60 healthy subjects were included in the study. Serum sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), selenium (Se), zinc (Zn), copper (Cu) levels, oxidative stress parameters, ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO) and ferroxidase (FOX) activity and an inflammatory marker, C-reactive protein (CRP), were examined in all participants. Results: IMA, IMA/Albumin (IMA/Alb), CAT, Cu, FOX and CRP levels were found to be significantly higher; Se, Zn and albumin levels were significantly lower in the patient group as compared to the control group. No significant difference was found between groups with regard to Na, K, Ca, P, Mg, Fe and MPO levels. Conclusions: Some trace element levels and oxidant-antioxidant balance were changed in psoriasis patients.

<b><i>Aim:</i></b> Vitamin D is one of the major hormones involved in phosphorus metabolism in the secosteroid structure. Studies have shown that low serum vitamin D levels are associated with chronic diseases such as autoimmune diseases, diabetes mellitus, chronic renal failure, depression, cardiovascular diseases, hypertension, and cancer. The aim of this study was to investigate serum vitamin D levels in the adult population according to age and gender in Karapınar, Turkey. <b><i>Materials and Methods:</i></b> Serum vitamin D levels of 6,774 patients admitted to Karapınar Public Hospital between January and December 2018 were evaluated according to age and gender, investigated, and retrospectively screened. Serum vitamin D level &#x3c;10 ng/mL is accepted as deficiency, 10–30 ng/mL as insufficiency, 30–100 ng/mL as sufficiency, and &#x3e;100 ng/mL as toxicity. <b><i>Results:</i></b> The study consisted of 5,111 women (75.5%) and 1,663 men (24%). The mean vitamin D levels were 14.6 ± 0.2 ng/mL in women and 17.8 ± 0.3 ng/mL in men. Vitamin D levels were found to be lower in both men and women as age progressed. Deficiency (&#x3c;10 ng/mL) of vitamin D was found in 83.8% of women and 18.2% of men, while insufficiency (10–30 ng/mL) of vitamin D was found in 69.6% of women and 30.4% of men. <b><i>Conclusion:</i></b> In this study, in patients who were admitted to our hospital in Karapınar City, serious vitamin D deficiency was detected. We recommend that people should take vitamin D and calcium supplements and they also should have more exposure to the sunlight.

Objective: Cardiovascular disease (CVD) is currently the leading cause of morbidity and mortality in patients with end-stage renal disease (ESRD). The aim of this study was to examine carotid artery intima-media thickness (CIMT) and valvular calcification in asymptomatic hemodialysis (HD) patients, to compare them with healthy subjects, and to identify risk factors associated with atherosclerosis.Materials and Methods: Forty-nine HD patients and age and sex-matched 48 healthy volunteers were enrolled in this study. Right and left carotid intima-media thicknesses (CIMTs) were measured, and echocardiographic evaluation of valve calcification was performed. CaxP product and parathormone (PTH) values were measured from venous blood samples. Result:The mean CIMT thicknesses were 0.86 ± 0.16 mm in the patient group and 0.61 ± 0.11 mm in the control group. Mean CIMT was significantly higher in the patient group (p <0.001) and valve calcification was measured as

Objectives Vitamin D is one of the major hormones involved in the metabolism of calcium (Ca) and phosphorus (P). In the present study, we aimed to determine the analytical performance of the immunoassay method used for determining plasma 25-hydroxyvitamin D [25(OH)D] levels in routine clinical practice in laboratories. Methods Venous blood samples were collected from 156 patients for the comparisons and were analyzed with Siemens ADVIA Centaur XPT, the Roche Cobas 6,000’s module e601, Abbott Architect i2000, and the liquid chromatography with tandem mass spectrometry (LC-MS/MS). Results The four methods were analyzed and compared through the Passing-Bablok regression for 25(OH)D, and the highest correlation was found at LC-MS/MS and Cobas 6,000’s module e601 (r=0.799), LC-MS/MS/Abbott Architect i2000, and LC-MS/MS/Siemens ADVIA Centaur XPT as r=0.736, 0.721, respectively. The correlation coefficient was found between Abbott Architect i2000 with Roche Cobas e601 and Siemens ADVIA Centaur XPT as r=0.934 and r=0.907, respectively. Also, the correlation coefficient was found between Roche Cobas e601 and Siemens ADVIA Centaur XPT as r=0.906. Conclusions The Roche Cobas assay showed better performance, compared with the other assays. Based on our findings, the chemiluminescence methods in automated systems seem to be expedient.

No abstract