Trace elements and oxidative stress status in patients with psoriasis

Abstract

Introduction: Psoriasis is a common, inflammatory skin disease of which etiopathogenesis is still not explained clearly, however in which trace elements and oxidative stress are considered to play a role. Aim: To evaluate the serum trace element and oxidative stress levels in patients diagnosed with psoriasis. Material and methods: A total of 87 psoriasis patients and 60 healthy subjects were included in the study. Serum sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), selenium (Se), zinc (Zn), copper (Cu) levels, oxidative stress parameters, ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO) and ferroxidase (FOX) activity and an inflammatory marker, C-reactive protein (CRP), were examined in all participants. Results: IMA, IMA/Albumin (IMA/Alb), CAT, Cu, FOX and CRP levels were found to be significantly higher; Se, Zn and albumin levels were significantly lower in the patient group as compared to the control group. No significant difference was found between groups with regard to Na, K, Ca, P, Mg, Fe and MPO levels. Conclusions: Some trace element levels and oxidant-antioxidant balance were changed in psoriasis patients.

Evaluation of Lactocare® Synbiotic Administration on the Serum Electrolytes and Trace Elements Levels in Psoriasis Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial Study

“…Psoriasis is a chronic, inflammatory, and immune-mediated disease characterized by the development of scaly, sharply demarcated erythematous, pruritic, indurated, and often painful skin plaques[ 33 ]. Despite the exact etiopathogenesis of psoriasis remains unknown, the increasing or decreasing of some trace elements and oxidative stress status are considered to play a role [ 8 ]. In a study by Sudhakar et al serum electrolytes level was measured in psoriasis patients.…”

“…Inducing oxidative stress and production of ROS have been suggested to play role in the etiopathogenesis of many skin chronic inflammatory diseases [ 8 ]. In particular, regarding psoriasis, excess ROS and a decline in endogenous antioxidant activities (such as SOD) are observed [ 13 ].…”

“…The common idea is that oxidative stress causes inflammation that plays a role in etiopathogenesis. Also, increasing or decreasing some trace elements are considered to play a role [ 6 – 8 ]. On the other hand, reactive oxygen species (ROS) which is produced from neutrophils, keratinocytes, and fibroblasts can activate neutrophils which can lead to the inflammatory process of psoriasis [ 9 – 11 ].…”

Sulforaphane Ameliorates the Severity of Psoriasis and SLE by Modulating Effector Cells and Reducing Oxidative Stress

“…Notably, oxidative stress is involved in the pathogenesis of psoriasis. A number of oxidative stress-related markers are increased in the plasma or serum of psoriatic patients, such as ischaemia-modified albumin (Kirmit et al, 2020), catalase (Kirmit et al, 2020), malondialdehyde (Kadam et al, 2010), and nitric oxide (Gabr and Al-Ghadir, 2012). Furthermore, the elevated levels of reactive oxygen species (ROS) are caused by active oxidative stress and initially trigger the abnormal activation of Th1 and Th17 cells (Lai et al, 2018).…”

The Involvement of Oxidative Stress in Psoriasis: A Systematic Review

“…A total of 53 studies evaluated the following markers or parameters of oxidative stress in patients with psoriasis and also the correlations between those markers and severity and duration of disease: catalase (CAT), myeloperoxidase (MPO), ferroxidase (FOX), ischemia modified albumin (IMA), paraoxonase-1 (PON-1), total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde (MDA), 8-hydroxy 2′-deoxyguanosine (8H2D), advanced oxidation protein products (AOPP), nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), reactive oxygen species (ROS), glutathione peroxidase (GSH-Px), glutathione (GSH), thioredoxin reductase (TrxR), ferric reducing ability of plasma (FRAP), arylesterase (AS), oxidative stress index (OSI), salivary peroxidase (Px), superoxide dismutase (SOD), advanced glycation end-products (AGE), lipid hydroperoxides (LOOH), oxidized LDL (OxLDL), nitric oxide (NO), 8-hydroxy guanosine (8-OHdG), inducible nitric oxide synthase (iNOS), glutathione reductase (GSH-R), 25-hydroxy vitamin D (25-OH-vitD), adenosine deaminase (ADA), thiobarbituric acid (TBA), total peroxide concentration (TPX), protein carbonyl compounds (PCC), pyrrolized protein (PP), oxidized glutathione (GSSG), total bilirubin (TB), direct bilirubin (DB), indirect bilirubin (IB), copper (Cu), iron (Fe), transferrin (Trf), autoantibodies anti-oxidized LDL (AuAb-oxLDL), interleukin-6 (IL-6), C-reactive protein (CRP), antibodies against carboxyethyllysine (Ab anti-CEL) and antibodies against carbocymethyllysine (Ab anti CML) [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , …”