Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus

Cardoso, Estela M. del Luján; Persi, Gabriel; González, Natalia; Tumilasci, Omar R.; Arregger, Alejandro Luis; Burgos, Myriam; Rodríguez, Viviana M; Molina, Ana; Contreras, Liliana Noemí

doi:10.1016/j.steroids.2006.12.003

Cited by 15 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same research group went on to apply the 25 mg test with salivary samples to check for adrenal insufficiency in patients with HIV 50 and patients with end-stage renal failure.…”

Section: Testing For Adrenal Insufficiencymentioning

confidence: 99%

Salivary steroid assays – research or routine?

2009

View full text Add to dashboard Cite

Salivary concentrations of unconjugated steroids reflect those for free steroids in serum although concentrations may differ because of salivary gland metabolism. Samples for salivary steroid analysis are stable for up to 7 days at room temperature, one month or more at 48C and three months or more at 2208C. When assessed against strict criteria, the evidence shows that salivary cortisol in evening samples or following dexamethasone suppression provides a reliable and effective screen for Cushing's syndrome. Sequential salivary cortisol measurements are also extremely helpful for the investigation of suspected cyclical Cushing's syndrome. There is potential for the identification of adrenal insufficiency when used with Synacthen stimulation. Salivary 17-hydroxyprogesterone and androstenedione assays are valued as non-invasive tests for the homemonitoring of hydrocortisone replacement therapy in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. The diagnostic value of salivary oestradiol, progesterone, testosterone, dehydroepiandrosterone and aldosterone testing is compromised by rapid fluctuations in salivary concentrations of these steroids. Multiple samples are required to obtain reliable information, and at present the introduction of these assays into routine laboratory testing is not justified.

show abstract

“…The same research group went on to apply the 25 mg test with salivary samples to check for adrenal insufficiency in patients with HIV 50 and patients with end-stage renal failure.…”

Section: Testing For Adrenal Insufficiencymentioning

confidence: 99%

Salivary steroid assays – research or routine?

2009

View full text Add to dashboard Cite

show abstract

“…Salivary cortisol (SC) concentrations accurately reflect FC plasma concentrations in non-cirrhotic patients [25][26][27][28][29][30][31][32], even in cases of hypoalbuminemia or CBG abnormality [25,29,[33][34][35][36]. However, no study assessed SC evaluation in cirrhotic patients.…”

Section: Introductionmentioning

confidence: 99%

Assessment of adrenal function in cirrhotic patients: Salivary cortisol should be preferred

Galbois

Rudler

Massard

et al. 2010

Journal of Hepatology

104

100

View full text Add to dashboard Cite

“…To assess endogenous estradiol concentrations, besides those of other steroid hormones, saliva is often used as the biological matrix of choice as it can be sampled non-invasively and may easily be collected, even at ambulatory settings. Further, salivary steroid hormone concentrations are closely correlated with the free, unbound hormone fraction in blood and thus provide an easily obtainable measure of the biologically active hormone fraction [15][16][17].…”

Section: Introductionmentioning

confidence: 99%