Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts

Abstract

<jats:p> 1 The effect of long-term ingestion of the industrial metals salts, manganese sulfate, aluminum chloride, lead acetate and copper chloride was investigated on aggression, sexual behavior and fertility in male rat. Adult male rats ingested solutions of these salts along with drinking water at a concentration of 1000 p.p.m. for 12 weeks. </jats:p><jats:p> 2 Male rat sexual behavior was suppressed after the ingestion of manganese sulfate, aluminum chloride, lead acetate and copper chloride. The ingestion of solutions of these salts markedly prolonged the intromission and ejaculation latencies. Aluminum chloride and copper chloride reduced the copulatory efficiency. </jats:p><jats:p> 3 Male rat aggression was also abolished after the ingestion of manganese sulfate, aluminum chloride, lead acetate and copper chloride. The ingestion of solutions of these salts markedly suppressed lateralizations, boxing bouts, fight with stud male and ventral presenting postures. </jats:p><jats:p> 4 Fertility was reduced in male rats ingested with lead acetate. The total number of resorptions was increased in female rats impregnated by males ingested with manganese sulfate and lead acetate. </jats:p><jats:p> 5 Body, absolute or relative testes, seminal vesicles weights were dropped in adult male rats ingested with manganese sulfate, aluminum chloride, lead acetate and copper chloride. However, the absolute or relative preputial gland weights were not affected. Collectively, these results suggest that the long-term ingestion of manganese sulfate, aluminum chloride, lead acetate and copper chloride would have adverse effects on sexual behavior, territorial aggression, fertility and the reproductive system of the adult male rat. </jats:p>

Potentiating response of D- Ribose-L-Cysteine on Sodium arsenate- induced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat

“…The present study showed that exposure to Arsenic caused severe testicular toxicity in rats, evidenced by the reduction in the testicular weight/body weight ratio relative to the controls, thereby leading to obstruction of spermatogenesis and steroidogenesis. Our results conform with the reports by Bataineh et al (1998) and Adelakun et al(2019). They deduced that the administration of metals to rats causes a reduction in spermatogenic cell population and a decrease in testicular cell's nuclei.…”

Role of propolis (bee glue) in improving histopathological changes of the kidney of rat treated with aluminum chloride

“…The present results showed that, oral administration AlCl 3 in rats group caused decrease in the body weight gain and weights of kidneys as compared with control group, this agreed with the finding of El‐Masry et al () who suggested that the reduction in body weight of treated rats with AlCl 3 could be attributed to the decrease in feed consumption, and transient diarrhea occurred, which resulted in lowering of final body mass of animals in comparison to the controls. In addition, the ingestion of AlCl 3 leads to decrease in absolute and relative testes weights and seminal vesicles weight (Bataineh et al, ). However, it was found that, propolis was capable of restoring the body weight in rats group administered AlCl 3 and propolis.…”

Copper influence on bank vole’s (Myodes glareolus) sexual behavior

“…In rats, oral administration of 200 mg/kg copper sulphate, a dose similar to the lower dose in our experiments, led to neurobehavioral abnormalities manifested in reduced latency to fall in a rotarod and lower attention percentage scores (Kumar et al 2015 ). Long-term ingestion of copper chloride suppressed the sexual behavior of male rats (Bataineh et al 1998 ), but that effect occurred after exposure to a much higher Cu dose (1000 mg/kg) than used in this study. Our experiments used copper doses equivalent to environmental levels found in polluted districts.…”

“…In view of these reproduction-related morphological disorders associated with copper, it is reasonable to suggest that copper might also modify rodents’ sexual behavior. To our knowledge, only two studies have been done to test this conjecture in vertebrates: in rats, ingesting copper-enriched food led to decreased aggression levels against same-sex individuals, and it suppressed male sexual behavior in the presence of rat females (Bataineh et al 1998 ; Chattopadhyay et al 1999 ). Therefore, in this paper, we have addressed the question: how do the environmentally available doses of copper (150 and 600 mg/kg) influence the sexual behavior of bank voles?…”