Assessment of Aging of the Human Skin by In Vivo Ultrasonic Imaging

Rigal, Jean de; Escoffier, Catherine; Querleux, Bernard; Faivre, B.; Agache, P; Lévêque, Jean-Luc

doi:10.1111/1523-1747.ep12319741

Cited by 221 publications

(179 citation statements)

References 4 publications

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“…Although the number of patients was small, no differences of age were found for either thickness or echogenicity among the controls. This is accordance with results by de Rigal and coworkers, 20 who by ultrasound imaging observed a phase of maturation up to 15 years of age, after which skin thickness did not vary significantly until after the seventh decade. Nor did the present study show differences in thickness and echogenicity between male and female controls (figs 2-5).…”

Section: Resultssupporting

confidence: 93%

Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis

Åkesson

Hesselstrand

Scheja

et al. 2004

Annals of the Rheumatic Diseases

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Background: Measurement of skin involvement is essential for diagnosis and prognosis in systemic sclerosis. Assessment by palpation skin score is the current method. Objective: To explore high frequency ultrasound as an objective method to improve skin characterisation by combining measurements of skin thickness and echogenicity. Methods: Skin thickness and echogenicity were measured at the proximal phalanx of the second digit, the back of the hand, the forearm, and the lower leg and, in order to separate limited (lSSc) from diffuse SSc (dSSc), at the chest in 16 patients with early disease and in 16 controls. Measurements were repeated in each patient three or four times with an interval of 1-2 years. Ultrasound measurements of skin thickness were compared with the palpation skin score. Results: Compared with controls, the skin was thickened on the phalanx, hand, forearm, and chest of patients with dSSc, but not patients with lSSc, at the 1 year examination. In dSSc the degree of thickening tended to diminish with time, and at 4 years, thickness was significantly decreased on the forearm and chest compared with the 1 year measurements. Low reflectancy was most pronounced at the 1 year evaluation on the forearm, hand, and phalanx in dSSc, and on the phalanx in lSSc. Conclusion: Separate measurements of skin thickness and echogenicity by high frequency ultrasound add a new dimension to the assessment of skin involvement in SSc, and this seems to be an objective noninvasive tool for use in the study of disease development and in clinical trials.

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Section: Resultssupporting

confidence: 93%

Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis

Åkesson

Hesselstrand

Scheja

et al. 2004

Annals of the Rheumatic Diseases

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“…Studies have revealed that SLEB becomes visible mainly after the 21-to 40-year interval, especially on photoexposed sites (2,16,17,18). De Rigal et al (7) concluded that the SLEB thickness was higher on the dorsal forearm -a site of chronic exposure to UV rays than on volar forearm, which suggested that SLEB reflects mainly photodamage. In our study SLEB was present in all 50 subjects aged > 65 years only on the dorsal forearm (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…All these factors cause the changes in dermal echogenicity. In 1989 de Rigal et al (7) showed that a low echogenic band-like structure is present in the subepidermal region of photoaged skin.…”

Section: Introductionmentioning

confidence: 99%

Identification of the Age Related Skin Changes Using High-Frequency Ultrasound

Kozárová

Kozar

Minarikova

et al. 2017

Acta Medica Martiniana

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A b s t r a c tSkin aging has become an area of increasing research interest in dermatovenerology. Changes in the skin associated with aging can be detected by high -frequency 20 MHz ultrasonography, which is a useful diagnostic technique allowing reliable imaging of cutaneous and superficial subcutaneous structures.Skin thickness is considered an objective parameter providing assessment of the influence of endogenous or exogenous factors, such as ultraviolet (UV) or infrared (IR) rays. Except for the changes in the skin thickness, there are also specific structural changes in the dermis of older subjects -subepidermal low echogenic band (SLEB) -that is a manifestation of photoaging severity. The main aim of this study was to identify and characterize the specific ultrasonographic changes of the cutaneous structure related to age and degree of photo exposure (the presence and measurement of SLEB).

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“…Aging is accompanied by various symptoms such as wrinkles, dryness, darkening, pigmentation, decreased dermal thickness and a loss of elasticity (2,3). Due to the gradual aging of various populations worldwide, and the advance of science associated with aging, a variety of anti-aging procedures have been developed, such as photoprotection, cosmetics, cosmeceuticals and antioxidants for prevention and treatment of skin aging (4).…”

Section: Introductionmentioning

confidence: 99%

Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

Hahn

Jung

Schrammek-Drusios³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Anti-aging cosmetics are widely used for improving signs of aged skin such as skin wrinkles, decreased elasticity, low dermal density and yellow skin tone. The present study evaluated the effects of cosmetic formulations, eye cream and facial cream, containing palmitoyl peptides, Silybum marianum (S. marianum) seed oil, vitamin E and other functional ingredients on the improvement of facial wrinkles, elasticity, dermal density and skin tone after 4 weeks period of application on aged human skin. Healthy volunteers (n=20) with aged skin were recruited to apply the test materials facially twice per day for 4 weeks. Skin wrinkles, elasticity, dermal density and skin tone were measured instrumentally for assessing the improvement of skin aging. All the measurements were conducted prior to the application of test materials and at 2 and 4 weeks of treatment. Crow's feet wrinkles were decreased 5.97% after 2 weeks of test material application and 14.07% after 4 weeks of application in comparison of pre-application. Skin elasticity was increased 6.81% after 2 weeks and 8.79% after 4 weeks. Dermal density was increased 16.74% after 2 weeks and 27.63% after 4 weeks. With the L * value indicating skin brightness and the a * value indicating erythema (redness), the results showed that brightness was increased 1.70% after 2 weeks and 2.14% after 4 weeks, and erythema was decreased 10.45% after 2 weeks and 22.39% after 4 weeks. Hence, the test materials appear to exert some degree of anti-aging effects on aged human skin. There were no abnormal skin responses from the participants during the trial period. We conclude that the facial and eye cream containing palmitoyl peptides and S. marianum seed oil, vitamin E and other ingredients have effects on the improvement of facial wrinkles, elasticity, dermal density and skin tone.

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Assessment of Aging of the Human Skin by In Vivo Ultrasonic Imaging

Cited by 221 publications

References 4 publications

Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis

Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis

Identification of the Age Related Skin Changes Using High-Frequency Ultrasound

Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

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