Assessment of anti-cyclic citrullinated peptide in psoriatic arthritis

Abstract

BackgroundAnti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as regards clinical and radiological associations. The current study assessed anti-CCP in PsA and determined its clinical and radiological associations.MethodsFour groups contributed to this study. 40 PsA, 40 psoriasis without arthritis, 40 RA and 40 healthy controls. They were tested for anti-CCP. Clinical and radiological data were collected and statistically compared between anti-CCP-positive and -negative PsA patients.ResultsSeven PsA (17.5%) and 34 RA (85%) were seropositive for anti-CCP. Patients of other groups were anti-CCP-negative. Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA. Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA.ConclusionAnti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis.

Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

“…A total of 119 studies met the selection criteria and were included. Of these, 19 studied clinical markers [ 18 – 36 ], 69 studied laboratory markers [ 27 , 37 , 38 , 40 – 55 , 57 – 73 , 75 – 96 , 124 – 133 ], and 32 studied genetic markers [ 97 – 113 , 115 – 123 , 134 – 139 ]. One study described both clinical and laboratory markers [ 27 ].…”

“…Of those 14 markers, six showed a positive association with the presence of PsA in Pso: the presence of anti-citrullinated protein antibodies (ACPA) [ 37 – 40 ], a higher level of IL-34 [ 56 , 66 ], a higher level of tumor necrosis factor alpha (TNFα) [ 56 , 64 ], a higher mean platelet volume (MPV) [ 68 , 69 ], a higher LDL:HDL ratio [ 62 , 64 , 71 , 76 ], and the presence of microRNA miR-146a-50 [ 78 , 79 ].…”

Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis

“…This rate is in good agreement with smaller studies of PsA patients, which have reported ACPA-positive rates ranging between 3.1 and 17.5% [ 5–15 ]. Although some studies [ 8 , 12 ], including a recent study from the CORRONA database (n = 958) [ 14 ], did not identify significant differences in measures of disease activity between ACPA-positive and ACPA-negative PsA patients, others have reported higher rates of erosive disease [ 7 , 9 , 10 ] and more involved joints [ 10 , 11 , 13 , 15 ] in PsA patients who were positive for ACPA. However, the conclusions of these studies are somewhat limited by their small size; the largest study reporting an association between ACPA seropositivity and disease activity included 192 PsA patients, of which 15 were ACPA-positive [ 11 ].…”

Evaluation, hallmark, clinical relevance and role of anti citrullin antibody, IgG and IgM rheumatoid factor with serological parameters of disease activity or both as overall sifted test in undifferentiated seronegative arthropathy with or without joint inflammation and bone structure differences. Boost, over helling or amplification to classification criteria to rheumathoid arthritis?

“…It is noted in the literature that these antibodies have significance in PsA for the evaluation of osteoporosis, erosive changes and bone destructiones -fractures. Data obtained for ACPA autoantibodies are not higher than previously tested kits from other researches [14][15][16][17][18][19]. The ACPA autoantibody as an isolated laboratory variable does not dominate with its performances in diagnose of early, undiferentiated PsA.…”