Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats

Abstract

The objective of the present study was to screen various solvent extracts of Polyalthia longifolia var. pendula (Annonaceae) leaf for anti-inflammatory activity and to evaluate the anti-inflammatory and hepatoprotective potency of the potent solvent extract. Successive extraction was performed with six different solvents, viz. petroleum ether, hexane, toluene, chloroform, acetone and methanol. Toluene, chloroform, acetone and methanol were used in acute inflammatory studies; the results revealed methanol as most potent extract. Hence three concentrations of methanolic extract (300, 600, 900 mg/kg) were used to evaluate its potential as an anti-inflammatory and hepatoprotective agent. Diclofenac sodium was used as the toxicant in hepatoprotective studies, in which various serum biochemical parameters and liver glycogen were assessed. The three concentrations of methanol showed anti-inflammatory activity comparable to that of the control (Diclofenac sodium). All the serum biochemical parameters studied revealed the hepatoprotective nature of the methanol extract, but a concentration effect was not observed. The results indicated that the methanolic extract of Polyalthia longifolia var. pendula leaf possesses significant anti-inflammatory and hepatoprotective activity. However, the appropriate effective concentration needs to be determined.

Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites

“…As it is noted that natural products and their semi-synthetic derivatives are potentially safer and more active than the synthetic compounds 19,20 , the metabolites from natural sources are extensively screened for their dual inhibitor properties. Several previous studies 21,22 have demonstrated good in vivo anti-inflammatory activities of Polyalthia longifolia (Family: Annonaceae) extracts. However, the specific metabolites that are responsible for this activity and the proper enzymatic investigations against COX-1, COX-2, and 5-LOX remained undetermined.…”

Acute oral toxicity ofPolyalthia longifoliavar.pendulaleaf extract in Wistar albino rats

“…pendula (Annonaceae) is a tall evergreen tree cultivated all over India. The plant has been used in the traditional system of medicine for the treatment of fever, skin diseases, hypertension (Kirtikar & Basu, 1995), hepatoprotective, anti-inflammatory (Tanna et al, 2009), antimicrobial (Faizi et al, 2003;Murthy et al, 2005;Nair & Chanda, 2006), hypoglycemic and antihyperglycemic (Nair et al, 2007) and antiulcer activities (Malairajan et al, 2008). Polyalthia cerasoides (Roxb.)…”

Polyalthia longifolia Promises to be a Potential Nutraceutical

“…In another study, the ethanolic and aqueous extracts of P. longifolia were found to reduce Carrageenan induced edema and inflammation [18]. Hepatoprotective potential of plant has also been demonstrated in an animal study [19,20].…”