Assessment of Anti-Quorum Sensing Activity for Some Ornamental and Medicinal Plants Native to Egypt

Zaki, Ahmed A.

doi:10.3797/scipharm.1204-26

Cited by 46 publications

(20 citation statements)

References 21 publications

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“…The extract was tested for the stated activity by Chromobacterium violaceum assay using the agar cup diffusion method. The extract of olives was not found active for antiquorum sensing activity [ 176 ].…”

Section: Pharmacologymentioning

confidence: 99%

Traditional Uses, Phytochemistry, and Pharmacology ofOlea europaea(Olive)

Hashmı

Khan

Hanif

et al. 2015

Evidence-Based Complementary and Alternative Medicine

207

161

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Aim of the Review. To grasp the fragmented information available on the botany, traditional uses, phytochemistry, pharmacology, and toxicology of Olea europaea to explore its therapeutic potential and future research opportunities. Material and Methods. All the available information on O. europaea was collected via electronic search (using Pubmed, Scirus, Google Scholar, and Web of Science) and a library search. Results. Ethnomedical uses of O. europaea are recorded throughout the world where it has been used to treat various ailments. Phytochemical research had led to the isolation of flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and other classes of secondary metabolites from O. europaea. The plant materials and isolated components have shown a wide spectrum of in vitro and in vivo pharmacological activities like antidiabetic, anticonvulsant, antioxidant, anti-inflammatory, immunomodulatory, analgesic, antimicrobial, antiviral, antihypertensive, anticancer, antihyperglycemic, antinociceptive, gastroprotective, and wound healing activities. Conclusions. O. europaea emerged as a good source of traditional medicine for the treatment of various ailments. The outcomes of phytochemical and pharmacological studies reported in this review will further expand its existing therapeutic potential and provide a convincing support to its future clinical use in modern medicine.

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Section: Pharmacologymentioning

confidence: 99%

Traditional Uses, Phytochemistry, and Pharmacology ofOlea europaea(Olive)

Hashmı

Khan

Hanif

et al. 2015

Evidence-Based Complementary and Alternative Medicine

207

161

View full text Add to dashboard Cite

show abstract

“…Hence, inhibition of these signaling molecules hinders the pathogenicity of P. aeruginosa, and could be used for prevention or treatment of its infections Several plants have QS inhibiting activities. Medicinal plants 6 and edible plants 7 exhibited QSI effects. Also, Streptomyces coelicoflavus isolated from soil microbiota produced 1 H-pyrrole-2-carboxylic acid with QSI effect 8 .…”

Section: Introductionmentioning

confidence: 99%

Quorum sensing inhibitory activity of sub-inhibitory concentrations of β-lactams

El-Mowafy

Galil

Habib³

et al. 2017

Afr H. Sci.

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Introduction: The virulence factors of Pseudomonas aeruginosa are under the control of quorum sensing (QS) signals. Hence, interference with QS prevents its pathogenesis. Objective: The aim of the present research is to assess the influence of some β-lactam antibiotics on cell communication and the release of different virulence factors. Methods: The minimal inhibitory concentrations of ceftazidime, cefepime and imipenem were evaluated by microbroth dilution method. The effect of sub-inhibitory concentration of the tested antibiotics on QS signals was investigated using reporter strain assay. In addition, different virulence factors (elastase, protease, pyocyanin and hemolysin) were estimated in the presence of their sub-inhibitory concentrations. Results: Low concentrations of ceftazidime, cefepime and imipenem caused significant elimination of the QS signals 3OH-C12-HSL and C4-HSL up to 1/20 MIC. Furthermore, low concentrations of the tested antimicrobials suppressed virulence factors elastase and hemolysin. Moreover, 1/20 of their MICs reduced elastase, protease, pyocyanin and hemolysin. Conclusion: Utilization of β-lactam antibiotics at low concentrations could be an effective approach for prevention and treatment of P. aeruginosa infection.

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“…It has been found that the components of burdock leaf exhibit high antibacterial activity (Zaki et al . ; Lou et al . ).…”

Section: Introductionmentioning

confidence: 99%

The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors ofPseudomonas aeruginosa

et al. 2017

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Assessment of Anti-Quorum Sensing Activity for Some Ornamental and Medicinal Plants Native to Egypt

Cited by 46 publications

References 21 publications

Traditional Uses, Phytochemistry, and Pharmacology ofOlea europaea(Olive)

Traditional Uses, Phytochemistry, and Pharmacology ofOlea europaea(Olive)

Quorum sensing inhibitory activity of sub-inhibitory concentrations of β-lactams

The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors ofPseudomonas aeruginosa

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