Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat

Lim, Kyu Hee; Han, Ji-Hui; Lee, Jae Yeon; Park, Young Shik; Cho, Yong Seok; Kang, Kyung-Don; Yuk, Won Jeong; Hwang, Keum Cheol; Seong, Su-Il; Kim, Bumseok; Kwon, Jungkee; Kang, Chang‐Won; Kim, Jong-Hoon

doi:10.1016/j.fct.2012.08.036

Cited by 27 publications

(23 citation statements)

References 39 publications

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“…Looking for similarities between the two groups, the results seem to indicate that the higher level of dosage was not enough or too high to induce further additive changes. Lim et al [22] reported that there were no difference in the improvement of diabetic parameters between 500 mg/kg/day fermented soybean extracts-treated group and 1,000 mg/kg/day treated groups. Although the administration of γ-PGA may modify lipid metabolism in the hypertriglyceridemic condition, the question regarding optimal effective dose at the physiological level needs further study.…”

Section: Discussionmentioning

confidence: 96%

“…Another study reported that hm γ-PGA from chungkookjang or natto could be a new material that shares many properties with mucilages, which are secondary plant compounds that have a high water-holding capacity [9]. The cholesterol-lowering effect of flax seed is attributed to its mucilage [22]. Moreover, a previous study shows that hm γ-PGA intake prevents visceral fat accumulation and decreases blood cholesterol level [34].…”

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confidence: 99%

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High-Molecular-Weight Poly-Gamma-Glutamate Protects Against Hypertriglyceridemic Effects of a High-Fructose Diet in Rat

Jeon

Kwak²,

Sung³

et al. 2013

J. Microbiol. Biotechnol.

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We studied the effects of 2 different dosages of highmolecular- weight poly-γ-glutamic acid (hm γ-PGA) derived from Bacillus subtilis chungkookjang on lipid metabolism in a high-fructose diet-induced hypertriglyceridemic animal model. For 4 weeks, rats were fed either AIN-93 diet (normal control, NC; n = 10) or modified AIN-93 diet in which cornstarch was substituted with 63% fructose (n = 30) to induce hypertriglyceridemia. After 4 weeks, the hypertriglyceridemic rats were treated with daily oral doses of 0 mg (hypertriglyceridemic control, HC), 2.5 mg (hypertriglyceridemic, low hm γ-PGA, HL), or 5 mg·kg·bw(-1)·d(-1) (hypertriglyceridemic, high hm γ-PGA, HH) hm γ-PGA for 4 weeks. The HL and HH groups exhibited significantly lower levels of serum triglyceride, total cholesterol, LDL cholesterol, and free fatty acids than the HC group. The administration of hm γ-PGA reduced serum ALT and AST levels. The activities of lipogenic enzymes such as hepatic malic enzyme and glucose-6-phosphate dehydrogenase as well as glucose-6-phosphate dehydrogenase mRNA expression were significantly decreased by hm γ-PGA administration (p < 0.05). These results indicate that hm γ- PGA has an anti-hypertriglyceridemic effect in highfructose diet-induced hypertriglyceridemic rats.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

High-Molecular-Weight Poly-Gamma-Glutamate Protects Against Hypertriglyceridemic Effects of a High-Fructose Diet in Rat

Jeon

Kwak²,

Sung³

et al. 2013

J. Microbiol. Biotechnol.

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“…Besides consumption in its raw form, soybean is also consumed in fermentation form such as Kochujang, Doenjang and Ganjang (Korean traditional soy sauce) in Korea. After fermentation with lactic acid bacteria (LAB), not only the physicochemical and taste properties are improved but also the bioactivity can be enhanced and exerts more benefits compared with the raw form such as growth inhibition of potential pathogens, reduction of serum cholesterol and modulation of the immune system (Lim et al ., ; Lee et al ., ; Singh et al ., ). In our previous research, a LAB strain named L. plantarum P1201 was used for soybean fermentation and resulted in a soy‐yogurt with enhanced antioxidant activity and higher levels of isoflavone aglycones such as daidzein, glycitein and genistein after 48 h fermentation (Hwang et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Fermented soy‐powder milk with Lactobacillus plantarum P1201 protects against high‐fat diet‐induced obesity

Xie

Hwang

et al. 2017

Int J of Food Sci Tech

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Summary Fermented soy‐powder milk (FSPM) with Lactobacillus plantarum P1201 contains more conjugated linoleic acid (CLA) and isoflavone aglycones compared with unfermented soy‐powder milk (UFSPM). In this study, the antiobesity effect of FSPM was investigated in a high‐fat diet (HFD)‐induced obesity model. Results showed that FSPM reduced the weight of body, body weight gain, liver and mesenteric white adipose tissue by 10.7%, 17.7%, 32.8% and 24.1%, respectively, compared with the HFD group. Meanwhile, FSPM suppressed the HFD‐induced increase of serum parameters such as total and low‐density lipoprotein, cholesterol, alanine transaminase, glucose and c‐peptide. To investigate how FSPM ameliorated obesity, several lipid metabolism and inflammation‐related genes in liver were analysed. FSPM significantly ameliorated HFD‐induced hepatic steatosis by down‐regulating peroxisome proliferator‐activated receptor gamma, lipoprotein lipase, fatty acid synthase, acetyl CoA carboxylase, adipocyte fatty acid‐binding protein, tumour necrosis factor alpha and interleukin 1 beta. Our results showed FSPM can protect against HFD‐induced obesity.

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“…(13,14). The beneficial properties of microbial DNJ are comparable to its mulberry leaves counterpart, especially in terms of antihyperglycemic (15)(16)(17) and anti-hyperlipidemic effects (6,18). While some microorganism can produce high amount of DNJ, most of the known DNJ-producing bacteria are isolated from soil which is not preferable to be applied in food product.…”

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confidence: 99%

Physiological Effects and Organ Distribution of <i>Bacillus amyloliquefaciens</i> AS385 Culture Broth Powder Containing 1-Deoxynojirimycin in C57BL/6J Mice

Parida

Takasu

Ito

et al. 2019

J Nutr Sci Vitaminol

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1-Deoxynojirimycin (DNJ) has been known as a potent a-glucosidase inhibitor from mulberry leaves and considered beneficial in prevention of type 2 diabetes. Due to limited amount of DNJ in mulberry leaves, recent studies have focused in finding alternative source that can produce higher amount of DNJ. Previously, we produced a high DNJ-containing culture medium from Bacillus amyloliquefaciens AS385 and constructed a concentration method of bacterial culture medium using cation exchange column. However, less complicated concentration procedure is necessary to save time and cost during the large-scale production. Therefore, we developed a simpler concentration method using anion exchange resin to yield B. amyloliquefaciens AS385 culture broth powder (CBP; 1% DNJ) and evaluated the physiological effects of 5-wk dietary CBP intake in C57BL/6J mice. CBP intake tended to suppress the elevation of blood glucose level during oral glucose tolerance test. Moreover, CBP intake significantly lowered the fasting plasma glucose level and white adipose tissue mass. Next, we evaluated the absorption and distribution of DNJ in mice organs after daily CBP intake. We found detectable amount of DNJ in organs with intestine and kidney as the major targeted organs. We concluded that the DNJ content in CBP is absorbed from digestive tract, distributed and accumulated in organs, which most likely to contribute to the alteration of blood glucose regulation and adiposity in C57BL/6J mice. Our study was the first to report the physiological effects of CBP produced from B. amyloliquefaciens AS385 and the organ distribution of DNJ from CBP.

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Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat

Cited by 27 publications

References 39 publications

High-Molecular-Weight Poly-Gamma-Glutamate Protects Against Hypertriglyceridemic Effects of a High-Fructose Diet in Rat

High-Molecular-Weight Poly-Gamma-Glutamate Protects Against Hypertriglyceridemic Effects of a High-Fructose Diet in Rat

Fermented soy‐powder milk with Lactobacillus plantarum P1201 protects against high‐fat diet‐induced obesity

Physiological Effects and Organ Distribution of <i>Bacillus amyloliquefaciens</i> AS385 Culture Broth Powder Containing 1-Deoxynojirimycin in C57BL/6J Mice

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