Assessment of antimicrobial effect of Biosilicate® against anaerobic, microaerophilic and facultative anaerobic microorganisms

Abstract

This study assessed the antimicrobial activity of a new bioactive glass-ceramic (Biosilicate®) against anaerobic, microaerophilic, and facultative anaerobic microorganisms. Evaluation of the antimicrobial activity was carried out by three methods, namely agar diffusion, direct contact, and minimal inhibitory concentration (MIC). For the agar diffusion technique, bio glass-ceramic activity was observed against various microorganisms, with inhibition haloes ranging from 9.0 ± 1.0 to 22.3 ± 2.1 mm. For the direct contact technique, Biosilicate® displayed activity against all the microorganisms, except for S. aureus. In the first 10 min of contact between the microorganisms and Biosilicate®, there was a drastic reduction in the number of viable cells. Confirming the latter results, MIC showed that the Biosilicate® inhibited the growth of microorganisms, with variations between ≤ 2.5 and 20 mg/ml. The lowest MIC values (7.5 to ≤ 2.5 mg/ml) were obtained for oral microorganisms. In conclusion, Biosilicate® exhibits a wide spectrum of antimicrobial properties, including anaerobic bacteria.

A novel bioactive vitroceramic presents similar biological responses as autogenous bone grafts

“…In addition, recent data showed that BiosilicateÒ exhibits antimicrobial activity [32], a highly favorable characteristic when using it for maxillary reconstructions, due to the oral microbiota. Roriz et al [28] have investigated the use of this biomaterial for filling teeth sockets after dental extractions of dogs, finding adequate condition to install the endosseous implants after 12 weeks, and also after 8 weeks of implants installation, suggesting that the new vitroceramic can be indicated for this practice.…”

Fabrication of bioactive glass-introduced nanofibrous membranes with multifunctions for potential wound dressing

“…The greatest rate of pH increase was recorded within the rst 4 h, and within 24 h a plateau (pH $ 9.0) was reached, which would be effective in inhibiting the growth of some bacteria. 8,9 However, the pH value in the Tris buffer, in which the pure polymer mats were immersed, showed a slight decrease ($7.05) within the initial two hours and then slightly increased to nearly 7.2. This is possibly attributed to the acetic acid residual, which has been used to dissolve chitosan.…”

“…Recently, some studies have found that the local release of inorganic ions from bioactive glasses (BGs) can suppress microorganisms, stimulate collagen production, and accelerate the wound healing process. [7][8][9][10] It was found that BGs can be combined with so tissue and promote so tissue regeneration. 11 Moreover, BG can also reduce the inammatory response and wound exudate, and has a certain antibacterial and hemostatic potential, which has a positive therapeutic effect on the wound.…”

A New Biocompatible and Antibacterial Phosphate Free Glass-Ceramic for Medical Applications

“…Often it is associated to a certain degree of cytotoxicity. However, several research works have proposed biocompatible glasses and glass ceramic with antibacterial properties910. It is critical to find a correct balance between bactericidal effects and biocompatibility properties.…”