Assessment of aortic elastic properties in patients with sarcoidosis

Ardıç, İdris; Yarlıoğlueş, Mikail; Doğdu, Orhan; Büyükoğlan, Hakan; Kanbay, Asiye; Akpek, Mahmut; Bol, Canan; Yüksel, Murat; Akkaya, Emre; Vuruşkan, Ertan; Kaya, Mehmet

doi:10.3109/08037051.2012.656397

Cited by 8 publications

(9 citation statements)

References 25 publications

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“…22 Sarcoidosis has been associated with an increased pulse wave index which may predict the early stages of atherosclerosis. 3,4,6,11…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Some reports indicate increased arterial stiffness in sarcoidosis, reflecting a very early stage of atherosclerosis. 3,4 The most important mechanism underlying atherosclerotic vascular changes in sarcoidosis is chronic inflammation while it may also be due to increased oxidative stress and low high-density lipoprotein cholesterol (HDL-C) levels since all of these are proatherogenic. 5 –7…”

Section: Introductionmentioning

confidence: 99%

“…Endothelial dysfunction has been reported in patients with sarcoidosis using noninvasive imaging techniques and certain biologic markers including malondialdehyde levels. 3,6,10,11…”

Section: Introductionmentioning

confidence: 99%

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Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis

et al. 2018

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A systemic inflammatory reaction is a common feature of both sarcoidosis and atherosclerosis. Endothelial-cell specific molecule 1 (endocan) is a marker of vascular pathology which also shows a correlation with inflammation, endothelial dysfunction, and atherosclerosis. The objective of this study was to evaluate the vascular involvement in sarcoidosis using serum endocan levels and brachial artery flow-mediated dilation (FMD), a marker of endothelial dysfunction. We included 53 patients with sarcoidosis without conventional cardiovascular risk factors and 40 healthy controls. Endothelial function was assessed using FMD. Endocan concentrations were measured using a commercially available enzyme-linked immunoassay. Patients with sarcoidosis had significantly higher endocan levels (306 [68] ng/mL vs 269 [73] ng/mL; P = .039) and lower FMD (2.7% [2.3%-3.2%] vs 8% [5%-13%]; P < .001) compared with the healthy group. A negative correlation was found between endocan levels and FMD in the sarcoidosis group ( r = -.325, P < .007). We conclude that sarcoidosis is associated with high levels of endocan and lower FMD values, which may indicate endothelial dysfunction and an early stage of atherosclerosis.

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“…22 Sarcoidosis has been associated with an increased pulse wave index which may predict the early stages of atherosclerosis. 3,4,6,11…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis

et al. 2018

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“…Nevertheless, Kizer et al 10 previously suggested a possible link between fibrotic lung diseases and increased prevalence of CVD. Furthermore, Ardic et al 11 recently reported alteration in elastic properties of the aorta, and data from Ivanisevic et al 12 revealed elevated oxidative stress, diminished antioxidative protection, and altered lipid profile in patients with sarcoidosis. The latest data from a prospective study including various forms of immune-mediated disorders demonstrated that patients with sarcoidosis also have significantly increased risk of hospitalization due to coronary artery disease, similar to patients suffering from other systemic inflammatory diseases.…”

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confidence: 99%

Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis

Vekić

Zeljković

Jelić‐Ivanović

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis.Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles.Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods.Results.-Compared to controls, patients had fewer LDL I subclasses (P , .001), but more LDL II and III (P , .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P , .001) and higher proportions of HDL 2a (P ¼ .006) and 3a particles (P ¼ .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P ¼ .02) and higher proportions of HDL 3a subclasses (P ¼ .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found.Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.

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“…Aortic distensibility was lower and aortic stiffness was higher in patients with cystic fibrosis compared with healthy controls, even before development of pulmonary hypertension. 14 Similar changes were observed in patients with subclinical hypothyroidism, 15 sarcoidosis, 16 α1-antitrypsin deficiency, 17 erectile dysfunction, 18 obstructive sleep apnea, 19 chronic kidney disease, 20 metabolic syndrome, 21 hypertrophic cardiomyopathy, 22 and coronary artery disease (Table 1). 23…”

Section: Resultsmentioning

confidence: 62%

Aortic Elasticity Evaluated by Pulsed Tissue Doppler Imaging of the Ascending Aorta in Different Diseases: A Systematic Review

Ren

Meng

2021

Angiology

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Several methods have been applied for the evaluation of aortic elasticity. Pulsed tissue Doppler imaging of the ascending aorta is a noninvasive method applied for the evaluation of aortic elasticity in wide variety of diseases which are reviewed in this study. A comprehensive systematic literature search was carried out in November 2019 using the English databases including PubMed, Scopus, Science Direct, and Embase. All references of eligible articles and published reviews on tissue Doppler imaging were searched for relevant publications. Data were extracted according to predefined criteria (including country of study origin, patient population, number of patients in case and control groups, and results of aortic elasticity evaluation in the specific patient groups compared with controls). Two independent reviewers extracted the data, and the results were checked, compared, and edited by the third reviewer. No formal assessment of the statistics of the primary data was made. The results showed that decreased aortic elasticity is not only present in cardiovascular diseases but also can be identified in diseases of other systems that affect cardiovascular system.

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Assessment of aortic elastic properties in patients with sarcoidosis

Abstract: We observed that elastic properties of the aorta alter in patients with sarcoidosis. We also have demonstrated a statistically significant correlation between aortic elastic properties and the disease duration.

Cited by 8 publications

References 25 publications

Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis

Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis

Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis

Aortic Elasticity Evaluated by Pulsed Tissue Doppler Imaging of the Ascending Aorta in Different Diseases: A Systematic Review

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