Assessment of appropriate medication- use by 2015 Beers criteria among elderly critically ill patients in Jordan.

Abstract

Background: Inappropriate prescribing can cause significant morbidity and mortality in geriatric patients. Studies implementing the updated 2015 American Geriatrics Society (ACG) Beers Criteria in the identification of potentially inappropriate medications (PIM) are lacking. In addition, there is limited information regarding PIM use in critically ill older adults.Objective: To investigate the prevalence, patterns and determinants of PIM among elderly critically ill patients in Jordan.Setting: critical care unit (surgical, medical, cardiac) at Jordan University Hospital, Amman, Jordan Method: A cross-sectional study conducted over a 5-month period. Patients 65 years and older, taking at least one medication and admitted to critical care unit, were included. PIM were identified and classified in accordance with the American Geriatrics Society 2015 Beers Criteria. Results:One hundred and fifty-four patients were included (55.8% males), the mean age was 75.4 ± 7.1 years. The median number of prescribed medications was 11 (IQR=6). The use of at least one PIM was identified in 51 (33.1%). In 90 cases (58.4%), medications to be used with caution in older adults were also evaluated. Patients who received at least one PIM were prescribed a higher total number of medications in the hospital (13 vs. 11.5, P<0.05). Diabetes was also significantly associated with PIM prescription (84.3% vs. 49.5%, P<0.005).Conclusion: PIM prevalence among ICU elderly patients was high (every third patient). The factors associated with PIM prescription included the total number of medications and presence of diabetes mellitus.

Potentially inappropriate medication use in elderly patients treated in intensive care units: A cross‐sectional study using 2019 Beers, STOPP/v2 Criteria and EU(7)‐PIM List

“…Similarly, at least one PIM use was noted in 98.2% of the ICU patients aged ≥60 according to 2012 Beers Criteria in a retrospective Brazilian study, and in more than 80% of the patients at ICU admission in another study by Floroff et al 20,21 PIM prevalence was 49.8% and 21.8%, respectively, according to the EU(7)‐PIM List and 2015 Beers Criteria in a retrospective study conducted in India with elderly in the ICU and internal medicine service, 22 where the prevalence as determined by the Beers Criteria was considerably lower than our results while EU(7)‐PIM List results were similar. At least one PIM, as identified by the 2015 Beers Criteria, was noted in approximately 33% of elderly patients hospitalized in the ICU of the university hospital in Jordan, 23 which was also considerably lower with respect to our results. Again, in another study conducted retrospectively in the ICU of a 3rd level hospital in China, one or more PIM was reported in 58.1% and 44.0% of the patients according to the 2015 Beers and STOPP/v2 Criteria, respectively 24 .…”

“…Actually, the number of studies conducted with ICU patients are limited in other countries as well. In these studies, the prevalence of PIM was reported to be between 20–80% according to the 2012 and 2015 Beers Criteria, around 45% according to the STOPP/v2 Criteria, and around 50% according to the EU(7)‐PIM List 20‐24 . Considering all these issues, there is an apparent need for prospectively designed studies with elderly ICU patients in order to determine and compare the prevalence of PIM using the current Beers (2019) Criteria, STOPP/v2 Criteria and the EU(7)‐PIM List.…”

Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey

“…Other studies have indicated that cerebral toxoplasmosis is one of the major opportunistic infections that occurs in 5–40% of patients with AIDS (36, 37). However, a most recent study in Uganda has reported a case of primary cerebral toxoplasmosis in an HIV-negative individual adult; indicating that HIV/AIDS may not be a prerequisite for cerebral toxoplasmosis (38).…”

Potentially Inappropriate Medication (PIMs) Identification Using 2019 Beers Criteria at a Secondary Referral Hospital in Jakarta

“…Hasil penelitian ini lebih rendah dari beberapa penelitian antara lain di di India 61,9% (Beers 2019) 21 , 45,75% (Beers 2019) 24 dan di Karawang 52,2% (Beers 2012) 15 . Namun pada penelitian lain kejadian PIMs didapatkan lebih rendah dibandingkan penelitian ini yaitu 33,1% (Beers 2015) 40 dan 34,8% (Beers 2012) 19 . Kejadian PIMs yang ditemukan dari beberapa penelitian persentasenya berbeda-beda, hal ini dapat disebabkan karena perbedaan tempat penelitian, jumlah sampel dan juga metode penelitian yang digunakan.…”