Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population

Nikolic, Z.; Savić‐Pavićević, Dušanka; Vučić, N.; Cidilko, S.; Filipović, Nataša; Cerović, Snežana; Vukotic, V.; Romac, Stanka; Brajušković, Goran

doi:10.1016/j.yexmp.2015.06.009

Cited by 40 publications

(24 citation statements)

References 32 publications

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“…Eventually, 14 eligible articles (29 studies for polymorphisms analysis of individual miRNA) were selected for our present meta-analysis. Eleven studies focused on miR-196a2 C>T (rs11614913) (Horikawa et al, 2008; Yang et al, 2008; George et al, 2011; Mittal et al, 2011; Du et al, 2014; Deng et al, 2015; Nikolic et al, 2015; Hashemi et al, 2016; Toraih et al, 2016a,b); 11 studies focused on miR-146a G>C (rs2910164) (Horikawa et al, 2008; Yang et al, 2008; Xu et al, 2010; George et al, 2011; Mittal et al, 2011; Wang et al, 2012; Du et al, 2014; Nikolic et al, 2014; Deng et al, 2015; Huang et al, 2015; Hashemi et al, 2016) and seven studies focused on miR-499 A>G (rs3746444) (George et al, 2011; Mittal et al, 2011; Du et al, 2014; Deng et al, 2015; Nikolic et al, 2015; Hashemi et al, 2016; Toraih et al, 2016a). Five articles (George et al, 2011; Mittal et al, 2011; Du et al, 2014; Deng et al, 2015; Hashemi et al, 2016) investigated polymorphisms of these three miRNAs.…”

Section: Resultsmentioning

confidence: 99%

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Association between Polymorphisms in MicroRNAs and Risk of Urological Cancer: A Meta-Analysis Based on 17,019 Subjects

Wang

Weng

et al. 2017

Front. Physiol.

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Accumulating evidence has demonstrated that some single nucleotide polymorphisms (SNPs) existing in miRNAs correlate with the susceptibility to urological cancers. However, a clear consensus still not reached due to the limited statistical power in individual study. Thus, we concluded a meta-analysis to systematically evaluate the association between microRNA SNPs and urological cancer risk. Eligible studies were collected from PubMed, Embase, Web of Science, and CNKI databases. Pooled odds ratio (OR) and corresponding 95% confidence interval (95% CI) were calculated to assess the strength of the relationships between three SNPs (miR-196a2, C>T rs11614913; miR-146a, G>C rs2910164; and miR-499, A>G rs3746444) and the risk of urological cancers. In addition, the stability of our analysis was evaluated by publication bias, sensitivity and heterogeneity analysis. Overall, a total of 17,019 subjects from 14 studies were included in this meta-analysis. We found that CT (miR-196a2, C>T rs11614913) was a risk factor for renal cell carcinoma (CT vs. CC: OR = 1.72, 95%CI = 1.05–2.80, P = 0.03, I2 = 66%), especially in Asian population (CT vs. CC: OR = 1.17, 95%CI = 1.04–1.32, P < 0.01, I2 = 0%). miR-146a G>C rs2910164 was a protective factor of urological cancers (C vs. G: OR = 0.87, 95%CI = 0.81–0.93, P < 0.01, I2 = 0%), especially for bladder cancer. miR-499 A>G rs3746444 was correlated with an increased risk of urological cancers, specifically in Asian population. In conclusion, our meta-analysis suggests that polymorphisms in microRNAs, miR-196a2, C>T rs11614913, miR-146a G>C rs2910164 and miR-499 A>G rs3746444, may be associated with the development of urological cancers and the risks mainly exist in Asian populations.

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Section: Resultsmentioning

confidence: 99%

“…Nikolic et al provided the evidence that miR-27a rs895819 was associated with the presence of distant metastasis among PCa patients (Nikolic et al, 2015). miR-196a2 C>T (rs11614913), miR-146a G>C (rs2910164), and miR-499 A>G (rs3746444) have been widely studied to evaluate the correlation with the risk of urological cancers.…”

Section: Introductionmentioning

confidence: 99%

Association between Polymorphisms in MicroRNAs and Risk of Urological Cancer: A Meta-Analysis Based on 17,019 Subjects

Wang

Weng

et al. 2017

Front. Physiol.

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“…Genomic polymorphisms of the miRNA genes could influence the structure, properties and expression of the miRNA, and consequently affect function of miRNA genes and susceptibility to ovarian cancer. Two common genetic variations of the miRNAs miR-146a and miR-196a2 have been observed, and have association with pathogenesis of multiple-type diseases Shen et al, 2015;Xu and Tang, 2015;Nikolić et al, 2015). Up to now, only three studies have reported a relationship between miR-146a and miR-196a2 polymorphisms and susceptibility to ovarian cancer (Shen et al, 2008;Pastrello et al, 2010;Liu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

miR-146a and miR-196a2 polymorphisms in ovarian cancer risk

Sun¹,

Zhang²,

Tong³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by polymerase chain reaction coupled with restriction fragment length polymorphism analysis. Unconditional multiple-logistic regression analysis indicated that the GG genotype of miR-146a was associated with an increased risk of ovarian cancer when compared to the CC genotype, and the adjusted OR (95%CI) was 3.73 (1.79-7.80). Moreover, the CG+GG genotype of miR-146a was associated with an increased risk of ovarian cancer compared with the CC genotype (OR = 1.68, 95%CI = 1.06-2.66), and the GG genotype had a higher risk of ovarian cancer than the CC+CG genotype (OR = 3.02, 95%CI = 1. 55-5.98). In conclusion, our study suggests that the miR-146a polymorphism is associated with 2 X.C. Sun et al. Genetics and Molecular Research 15 (3): gmr.15038468 increased risk of ovarian cancer and could be used as a biomarker for ovarian cancer susceptibility.

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“…Rs11614913 (T>C) is a common variant in pre-miR-196a2 that plays a role in the development of multiple cancer types, including gastric cancer (Peng et al, 2014;Ni et al, 2015;Nikolić et al, 2015;Qi et al, 2015;Wu et al, 2015). Several studies have evaluated the effect of this polymorphism on gastric cancer risk in different populations, but the results are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

Bai

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People's Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the primers of polymerase chain reaction. Using the chisquare test, we found that patients with gastric cancer were more likely to be alcohol drinkers (c 2 = 4.4, P = 0.04), to have a family history of cancer in the first relatives (c 2 = 5.29, P = 0.02), and to be infected with Helicobacter pylori (c 2 = 23.39, P < 0.001). A significant difference in the genotype distributions of rs11614913 was observed in our study (c 2 = 6.66, P = 0.04). By logistic regression analysis, we found that the CC genotype of rs11614913 was associated with an increased risk of gastric cancer in a codominant model (OR = 2.68, 95%CI = 1.17-6.44). By stratification analysis, we found that the CC genotype was associated with a strongly increased risk of gastric cancer in drinkers when compared with the TT+TC genotype (OR = 5.63, 95%CI = 1.54- 30.76). In conclusion, the results of our study suggest an association between the rs11614913 gene polymorphism and an elevated risk of gastric cancer, especially in drinkers.

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Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population

Cited by 40 publications

References 32 publications

Association between Polymorphisms in MicroRNAs and Risk of Urological Cancer: A Meta-Analysis Based on 17,019 Subjects

Association between Polymorphisms in MicroRNAs and Risk of Urological Cancer: A Meta-Analysis Based on 17,019 Subjects

miR-146a and miR-196a2 polymorphisms in ovarian cancer risk

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

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