Assessment of autonomic function in humans by heart rate spectral analysis

Pomeranz, Bruce; Macaulay, Robert J.B.; Caudill, Marie A.; Kutz, Ilan; Adam, Dan; Gordon, David; Kilborn, K. M.; Barger, A. C.; Shannon, Daniel C.; Cohen, Richard J.

doi:10.1152/ajpheart.1985.248.1.h151

Cited by 1,901 publications

(1,660 citation statements)

References 6 publications

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“…During stationary resting conditions, different maneuvers, such as controlled breathing, muscarinic blockade with atropine or cold face immersion, have shown that the high frequency component of HRV, as well as timedomain parameter RMSSD (in large part), are predominantly the result of fluctuations in vagal-cardiac nerve activity (Akselrod et al 1981;Berntson et al 1993;Cacioppo et al 1994;Pomeranz et al 1985;Task Force, 1996). Therefore, high frequency power (HFP) may provide an index of vagal activity, but the potential influence of respiration on RSA must be considered, because the rate, and also slightly the depth, of breathing has been found to affect RSA (Akselrod et al 1981;Task Force, 1996).…”

Section: Frequency Domain Analysismentioning

confidence: 99%

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Heart rate variability is related to training load variables in interval running exercises

Kaikkonen¹,

Hynynen

Mann

et al. 2011

Eur J Appl Physiol

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Section: Frequency Domain Analysismentioning

confidence: 99%

“…LFP, with a center frequency of about 0.1 Hz, appears to reflect a baroreflex resonance frequency (Berntson et al 1997;Pomeranz et al 1985). It has been suggested to reflect sympathetic outflow, especially when expressed in normalized units (nu) (Malliani et al 1994).…”

Section: Frequency Domain Analysismentioning

confidence: 99%

Heart rate variability is related to training load variables in interval running exercises

Kaikkonen¹,

Hynynen

Mann

et al. 2011

Eur J Appl Physiol

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“…156 ± 158 One technique used in the determination of HRV, referred to as power spectral analysis, produces spectra of heart rate oscillations in the frequency domain by mathematically transforming a series of sequential RRI into speci®c frequency components (high frequency: HF RRI , and low frequency: LF RRI ). The HF RRI component of HRV is believed to represent solely e erent vagal in¯uences, 159 whereas interpretation of the LF RRI component is more controversial. The general consensus, however, is that this component estimates cardiac sympathetic modulation.…”

Section: Hrv and Bpv Analysismentioning

confidence: 99%

Risk factors for atherogenesis and cardiovascular autonomic function in persons with spinal cord injury

et al. 1999

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Persons with spinal cord injury (SCI) have been recognized to have several metabolic changes that adversely impact their risk for cardiovascular disease. An increased prevalence of disorders of carbohydrate metabolism and dyslipidemia may be related predominantly to paralysis with immobilization and associated loss of lean body tissue and gain in relative adiposity. Studies have reported an increased risk of vascular disease in those with SCI. As such, an understanding of the constellation of carbohydrate and lipid changes that occur after SCI is relevant to the clinical practice of medicine in this population. Oral glucose tolerance testing and associated studiesImpaired glucose tolerance and diabetes mellitus are more prevalent in individuals with SCI than in those who are able-bodied. 1 ± 4 In most of the individuals with SCI and abnormal carbohydrate tolerance, resistance to insulin mediation of glucose uptake by peripheral tissues may be demonstrable. In the presence of insulin resistance, the normal homeostatic response to glucose challenge is increased pancreatic b-cell secretion of insulin. If the compensatory response of the pancreas is insu cient to control the serum glucose concentration, worsening of carbohydrate tolerance will ensue.Bauman et al 3 performed a 75 g oral glucose tolerance test in 100 male veterans with SCI and in 50 able-bodied veteran controls. According to criteria established by the World Health Organization, 5 22% of those with SCI were diabetic whereas only 6% of the control group were diabetic. Eighty-two per cent of the controls had normal oral glucose tolerance, compared with 38% of those with quadriplegia and 50% of those with paraplegia. Subjects with SCI had signi®cantly higher mean plasma glucose and insulin values at several points during the oral glucose tolerance test when compared with controls ( Figure 1). In subgroups, determinants of insulin sensitivity were measured: per cent lean body mass, per cent fat mass, and cardiopulmonary ®tness. Values for insulin sensitivity were linearly related with those of ®tness (VO 2 max) determined from a progressive incremental upper-body exercise stress test. Insulin sensitivity was suggestively correlated with lean body mass, and negatively correlated with body fat. Thus, in a relatively small subgroup of untrained subjects with paraplegia, the strongest determinant of insulin sensitivity was cardiopulmonary ®tness.In 201 non-veteran subjects with SCI, Bauman et al 2 studied the relationship of oral carbohydrate tolerance after a 75 g glucose load to several variables, including level and completeness of lesion, gender, ethnicity, age, duration of injury, and anthropometric measures. Of the total group, 27 (13%) had diabetes mellitus and 56 (29%) had impaired glucose tolerance. 2,6 The subjects with complete tetraplegia had sign®cantly worse carbohydrate tolerance (Figure 2) and were more frequently classi®ed with a disorder of carbohydrate tolerance than the other neurological de®cit subgroups. 2 There were no signi®cant gend...

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“…When applied to the heart rate, power spectral analysis allows for the detection of the low frequency component (LF, marker of sympathetic activity), and of the high frequency components (HF, related to the respiratory activity, which is mediated by the vagus nerve). [11][12][13][14] The ratio between the LF and HF components (LF/HF) is, therefore, an index of the sympatho-vagal balance. 15 …”

Section: Introductionmentioning

confidence: 99%

Baroreflex control of heart rate is impaired in pre-eclampsia

et al. 1999

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Autonomic nervous dysfunction, such as parasympathetic and sympathetic impairment, has been suggested as possible cause of pre-eclampsia, but the studies are not conclusive. Our purpose was to assess non-invasively if pre-eclampsia is associated with a decreased baroreflex function. Nine women with pre-eclampsia (PE), eight normotensive pregnant women, and seven healthy normotensive non-pregnant women were studied. Continuous finger blood pressure was recorded by a Portapres device in the left lateral recumbent position and active standing. Baroreflex gain was evaluated by

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Assessment of autonomic function in humans by heart rate spectral analysis

Cited by 1,901 publications

References 6 publications

Heart rate variability is related to training load variables in interval running exercises

Heart rate variability is related to training load variables in interval running exercises

Risk factors for atherogenesis and cardiovascular autonomic function in persons with spinal cord injury

Baroreflex control of heart rate is impaired in pre-eclampsia

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