Assessment of bone repair in critical-size defect in the calvarium of rats after the implantation of tricalcium phosphate beta (β-TCP)

Silva, Leonardo de Freitas; Reis, Erik Neiva Ribeiro de Carvalho; Barbara, Tânia Aparecida; Bonardi, João Paulo; Garcia, Idelmo Rangel; Carvalho, Paulo Sérgio Perri de; Ponzoni, Daniela

doi:10.1016/j.acthis.2017.07.003

Cited by 13 publications

(15 citation statements)

References 22 publications

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“…The CSD filled with AUT presented similar closure to the COA group and higher bone formation than the CSD filled with HA / TCP and TCP, as well as fewer biomaterial remnants than the CSD filled with DBB. These data, together, show that the area repaired by the use of AUT presented the best biological characteristics among the groups evaluated, confirming its position as a gold standard bone substitute because it is the only one that presents the biological properties of bone formation such as osteoinduction, osteogenesis and osteoconduction 4,7 .…”

Section: Discussionsupporting

confidence: 53%

“…TCP has presented clinical outcomes in maxillary sinus elevation similar to DBB 12,13 and AUT 6 . In contrast to other osteoconductive bone substitutes, TCP has been related with higher resorption rates, which could indicate that this bone substitute can induce a greater amount of new bone in the grafted area 7 .…”

Section: Introductionmentioning

confidence: 95%

“…For the calculation of the sample size, bone formation data on CSD that were filled with DBB and TCP and were evaluated by histometric analysis by Silva et al 7 were used. The minimum difference in means between the groups where significant differences were found was 27.9% with a standard deviation of 9.0%.…”

Section: Groupsmentioning

confidence: 99%

“…The regeneration of bone defects caused by different aetiological agents remains a major challenge in the medical and dental fields [1][2][3] . Although autogenous bone graft (AUT) is considered the gold standard for bone availability enhancement techniques [4][5][6][7] , the use of this graft presents some limitations, such as the donor bed morbidity, the increased surgical time, the limited amount of available graft and the elevated resorption rates, especially when used in particulate form 5 .…”

Section: Introductionmentioning

confidence: 99%

“…The direct comparison between the different osteoconductive bone substitutes has been little explored. A preclinical study compared the potential for the bone repair of TCP with DBB, AUT, and coagulum (COA) in critical-sized defects (CSDs) in rat calvaria 7 . In this study, TCP induced the bone repair with a similar biological characteristic as the areas grafted with DBB, however, with lower bone formation than AUT.…”

Section: Introductionmentioning

confidence: 99%

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Bone repair induced by different bone graft substitutes in critical-sized defects in rat calvaria

Aroni

Neto

Oliveira

et al. 2019

Rev. odontol. UNESP

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Introduction The use of bone substitutes in grafting procedures as an alternative of the use of autogenous bone graft has been indicated, however, the direct comparison between these biomaterials has been little explored. Objective To evaluate the effect of different osteoconductive bone substitutes on the bone repair in critical-sized defects (CSDs) in rat calvaria. Material and method One CSD with an 8 mm diameter was made in each of the 40 rats used in this study. The animals were randomly allocated into 5 groups (n=8), according to the type of bone substitute used to fill the CSD: COA (Coagulum); AUT (autogenous bone); DBB (deproteinized bovine bone graft); HA/TCP (biphasic ceramic composed of hydroxyapatite and β-phosphate tricalcium); and TCP (β-phosphate tricalcium). A microtomographic analysis was performed to evaluate the remaining defect linear length (DLL) of the CSD and the volume of the mineralized tissues (MT) within the CSD at 3, 7, 15 and 30 days after the surgical procedure. In addition, a histometric analysis was performed to evaluate the composition of the repaired bone tissue (% Bone and % Biomaterial) at the 30-day period. Result It was shown that the COA had the lowest DLL and MT within the CSD. In addition, the COA presented the highest % of bone in CSD. The DBB had a higher MT and a higher % of bone substitute particles in the CSD than the AUT and TCP groups. The DBB and AUT groups presented higher % of bone in the CSD than the TCP group. Conclusion The use of the DBB promoted a better pattern of bone volume gain and formation compared to TCP and HA / TCP but was biologically inferior to the AUT.

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Section: Discussionsupporting

confidence: 53%