Assessment of cardiac involvement of hepatitis C virus; tissue Doppler imaging and NTproBNP study

Saleh, Ahmed; Matsumori, Akira; Negm, Hany; Fouad, Hany Ahmed; Onsy, Ahmed; Shalaby, Mohamed; Hamdy, Enas

doi:10.1016/j.jsha.2011.04.005

Cited by 16 publications

(13 citation statements)

References 11 publications

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“…According to literature, in our study we found a significant increase in cardiac mass, atrial volume and diastolic dysfunction in HCV‐related cirrhotic patients . The increase in left ventricular mass is due to volume overload secondary to expansion of blood volume and activation of neuro‐hormonal systems commonly observed in these patients .…”

Section: Discussionsupporting

confidence: 69%

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Novo

Macaione

Giannitrapani

et al. 2018

Aliment Pharmacol Ther

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Section: Discussionsupporting

confidence: 69%

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Novo

Macaione

Giannitrapani

et al. 2018

Aliment Pharmacol Ther

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“…In addition to hepatitis, hepatitis C virus (HCV) infection frequently causes cardiac and renal abnormalities, including hypertrophic cardiomyopathy and DCM. In Egypt, in patients with HCV infection, echocardiographic abnormalities were frequently found, such as dilated left atrium, dilatation and hypertrophy of the left ventricle and disturbed diastolic and systolic function of the left ventricle 206 . In China, NT-proBNP levels are higher in patients with HCV-infection-associated hepatitis than in those with hepatitis B virus infection or in healthy controls 207 .…”

Section: Inflammationmentioning

confidence: 99%

Dilated cardiomyopathy

Schultheiss

Fairweather

Caforio

et al. 2019

Nat Rev Dis Primers

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www.nature.com/nrdp P r i m e r 0123456789(); P r i m e r 0123456789(); 4 | Article citation ID: (2019) 5:32 www.nature.com/nrdp P r i m e r 0123456789(); P r i m e r 0123456789(); P r i m e r 0123456789(); 7 NATURE REVIEwS | DIsEAsE PRIMERs | Article citation ID: (2019) 5:32 P r i m e r 0123456789(); P r i m e r 0123456789(); 9 NATURE REVIEwS | DIsEAsE PRIMERs | Article citation ID: (2019) 5:32 P r i m e r 0123456789(); P r i m e r 0123456789(); P r i m e r 0123456789(); (2019) 5:32 www.nature.com/nrdp P r i m e r 0123456789(); P r i m e r 0123456789();

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“…Data entry, processing and statistical analysis was carried out using MedCalc ver. 18 Inferential statistics carried out using (Chi square, independent student's t test, and Spearman correlation coefficient).…”

Section: Discussionmentioning

confidence: 99%

“…In a study of, Saleh et al, 2011, who reported that, the first direct evidence that HCV infection causes diastolic dysfunction without any other predisposing factors, probably Diabetic Patients with Hepatitis C Virus (HCV) due to chronic inflammatory reaction with mild fibrosis in the heart. Previous studies did not follow strict inclusion and exclusion criteria that confirm the independent role of HCV to cause diastolic dysfunction [18].…”

Section: Discussionmentioning

confidence: 99%

Tissue Doppler Imaging Assessment of Left Ventricular Function in Diabetic Patients with Hepatitis C Virus (HCV)

Tnoby¹,

Mostafa²,

Ebraheem³

et al. 2019

CCR

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Background & Purpose: Hepatitis C virus (HCV) is the motive of many distinctive kinds of heart illnesses globally. Up till now, few cardiologists are aware of (HCV) as an etiology of heart sickness and its treatment. It has been nicely documented that the presence of diabetes mellitus (DM) changed into carefully connected to cardiovascular disorder. The aim of this work was to evaluate the left ventricular function in diabetic patient with hepatitis C (HCV) using tissue Doppler imaging "TDI". Study design: Comparative study. Setting: Menofia hospitals, Police Academic Hospital and Kafr El-Sheikh hospital from October 2016 to November 2018. Subjects: We included 50 adult HCV patients, allocated into 2 groups with BMI, age and sex matching. Group A: 25 patients below 50 years old who were diabetic (DM), and infected with HCV. Group B: 25 patients below 50 years old with HCV without Dm. Methods: All patients were subjected to Echocardiographic analysis, Doppler tissue imaging, ECG, blood sugar investigations and PCR for HCV. Results: In the studied population, we found that, comparative study between the 2 groups revealed; significant increase in LA mass index, in DM & HCV group (p = 0.035). Non-significant difference as regards all the remaining Echocardiographic variables (p > 0.05). Regarding correlations among DM & HCV cases; Mitral E had a highly significant positive correlation with HCV-PCR (p < 0.01). E/E' ratio and isovolumic relaxation time had a significant positive correlation with HCV-PCR (p < 0.05 respectively). It also shows that; septal mitral E' had a highly significant negative correlation with HCV-PCR (p = 0.004). And also shows that; the remaining Tissue Doppler Echocardiographic parameters, had non-significant correlation with HCV-PCR (p > 0.05). Conclusion: To conclude, our data suggests that, HCV infection had a significant impact on Lt ventricular diastolic function without any other predisposing factors probably due chronic inflammatory reaction and mild fibrosis of the heart muscle, previous studies did not follow strict inclusion and exclusion criteria that confirm the independence role of (HCV) infection to cause diastolic dysfunction. also, the presence of DM in addition to HCV infection add no more adverse effect on cardiovascular outcomes.

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Assessment of cardiac involvement of hepatitis C virus; tissue Doppler imaging and NTproBNP study

Cited by 16 publications

References 11 publications

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Dilated cardiomyopathy

Tissue Doppler Imaging Assessment of Left Ventricular Function in Diabetic Patients with Hepatitis C Virus (HCV)

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