Assessment of cardiovascular risk in paediatric peritoneal dialysis patients: a Turkish Pediatric Peritoneal Dialysis Study Group (TUPEPD) report

Bakkaloğlu, Sevcan A.; Saygılı, Arda; Sever, Lale; Noyan, Aytül; Akman, Sema; Ekı̇m, Mesı̇ha; Aksu, Nejat; Doğanay, Beyza; Yıldız, Nurdan; Düzova, Ali; Soylu, Alper; Alpay, Harika; Sönmez, Ferah; Çivilibal, Mahmut; Erdem, Sevcan; Kardelen, Fırat

doi:10.1093/ndt/gfp297

Cited by 63 publications

(49 citation statements)

References 58 publications

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“…25,30,31 The prevalence of LVH in predialysis pediatric patients has been varied between 7% and 39% in different studies 3,6,9,10 and anemia, hypertension, age, increased cardiac output, elevated PTH levels have been reported as independent predictors of LVH. 3,18,19,32,33 In our study, we determined that LVH was more frequent than those found in previous studies, with a prevalence of 44%, and as expected, tended to be higher in severe CRI. LVMI correlated negatively with Hb level, age, height, while positively with E/E 0 ratio.…”

Section: Discussionsupporting

confidence: 79%

“…In previous studies, reduced E/A ratios in children on dialysis have often been reported. 7,8,18,19 In addition, Mitsnefes et al 6 determined low E/A ratios in predialysis pediatric patients as well. Whereas, in another studies in CKD patients, E/A ratios were similar to that in healthy children, in contrast to Mitsnefes et al 9, 10 We also did not find any significant difference in E/A ratios between the patient and control groups.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease

et al. 2015

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease

et al. 2015

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“…The association between cIMT and MAP, as well as highsensitivity C-reactive protein in peritoneal dialyzed children has been reported. In this group of patients cIMT correlated negatively with hemoglobulin and albumin levels, and with Kt/V urea [16].…”

Section: Atherosclerosis and Vascular Stiffnessmentioning

confidence: 63%

Cardiovascular Changes during Chronic Hypertensive States

Swathi¹,

Rizwan²

2016

jmscr

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It is well established that elevated blood pressure constitutes a major risk factor for coronary heart disease, arrythmias, heart failure, cerebrovascular disease, peripheral artery disease and renal failure. Blood pressure level and the duration of arterial hypertension (HTN) impact target organ damage. Many studies in adults have demonstrated the role of antihypertensive therapy in preventing cardiovascular (CV) events. The so-called hard end-points, such as death, myocardial infarction (MI) or stroke, are rarely seen in children, but intermediate target organ damage, including left ventricular hypertrophy, increased intima-media thickness and microalbuminuria, is already detectable during childhood. The goal of antihypertensive treatment is to reduce the global risk of CV events. In the adult population stratification of CV risk is based on blood pressure level, risk factors, subclinical target organ damage and established CV and kidney disease. Increased CV risk begins early in the course of kidney disease, and CV diseases are the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). Children with CKD are especially prone to the long-term effects of CV risk factors, which result in high morbidity and mortality in young adults. To improve the outcome, pediatric and adult CKD patients require nephro-and cardioprotection.

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“…Associated factors include hypertension, body mass index, type of peritoneal dialysis applied, anemia and hyperparathyroidism, as well as the etiology of CKD other than renal dysplasia 8,14,15 .…”

Section: Discussionmentioning

confidence: 99%

Compromiso cardiovascular en pacientes pediátricos en diálisis peritoneal crónica

2017

Rev. chil. pediatr.

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Peritoneal dialysis (PD) is the most common renal replacement therapy used in pediatric patients with end stage renal disease. This population has a mortality rate 1,000 times greater compare to pediatric population, mainly due to cardiovascular causes. Objective: To characterize pediatric patients on chronic PD in relation to dialysis and cardiovascular outcome. Patients and Methods: Cross sectional study. Patients in stable PD according to DOQI criteria were selected. Epidemiological, dialytic, biochemical and cardiovascular variables were registered. Left Ventricular Mass Index (LVMI) was calculated by height/age (g/m 2.7 ). Left Ventricular Hypertrophy (LVH) was diagnosed with > 38.6 g/m 2.7 , severe LVH > 51 g/m 2.7 . Data were analyzed using STATA 11.0. continuous variables using ANOVA test and categorical variables were analyzed using c 2 test or Fisher's exact test. Results: 21 patients, 11 males. Mean age 9.2 ± 3.52 years. The most frequent diagnosis was renal dysplasia (52%). Residual and Peritoneal KtV were 0.8 and 1.9 respectively. Fifty-two percent of patients showed LVH, 91% in severe range. A significant relationship between ultrafiltration/m2 and systolic blood pressure was depicted. Also a significant relationship between left ventricular mass index and hemoglobin (p < 0.05) was founded. Conclusions: The majority of the population showed left ventricular hypertrophy -particularly severe LVH-, which confirms an increased CV risk in this population. Blood pressure and loss of ultrafiltration were founded to be correlated to LVH.

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Assessment of cardiovascular risk in paediatric peritoneal dialysis patients: a Turkish Pediatric Peritoneal Dialysis Study Group (TUPEPD) report

Cited by 63 publications

References 58 publications

Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease

Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease

Cardiovascular Changes during Chronic Hypertensive States

Compromiso cardiovascular en pacientes pediátricos en diálisis peritoneal crónica

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