Assessment of carotid artery intima‐media thickness in patients with obstructive sleep apnoea

Liao, L-J; Cho, T.-Y.; Huang, Tsung‐Wei

doi:10.1111/coa.12823

Cited by 9 publications

(4 citation statements)

References 21 publications

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“… 17 , 21 Several studies have focused on highlighting the markers of cardiovascular risk associated with OSAS, in particular through the thickness of the intima media measured via an ultrasound of the vessels of the neck. 22 – 24 MPV is measured by automated hematology analyzers. 8 Using it as a marker to assess the cardiovascular risk in OSAS is quite simple and a cheap method when compared to other methods.…”

Section: Discussionmentioning

confidence: 99%

Association between mean platelet volume and cardiovascular disease in obstructive sleep apnea syndrome

et al. 2023

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Objectives: Obstructive sleep apnea syndrome is associated with cardiovascular diseases. Mean platelet volume has emerged as a marker of prothrombotic conditions and cardiovascular risk. The aim of this study was to investigate the association between the mean platelet volume and cardiovascular diseases in patients with obstructive sleep apnea syndrome. Methods: The medical records of 207 patients were analyzed. Obstructive sleep apnea syndrome was diagnosed by polygraphy, and patients were classified according to apnea–hypopnea index: control group: individuals with simple snoring (apnea–hypopnea index < 5), mild obstructive sleep apnea syndrome group (5 ⩽ apnea–hypopnea index < 15), moderate obstructive sleep apnea syndrome group (15 ⩽ apnea–hypopnea index < 30), and severe obstructive sleep apnea syndrome group (apnea–hypopnea index ⩾ 30). Mean platelet volume was obtained from medical records. Cardiovascular diseases were defined if patients had hypertension, heart failure, coronary artery disease, or arrythmia. The independent predictors related to cardiovascular diseases in obstructive sleep apnea syndrome were determined by using multiple logistic regression analysis. Results: Of the patients, 175 were included in the analysis. Sixty-three (36%) were males and 112 (64%) were females. The mean age was 51.85 ± 11 years. There were, 26 (14.9%), 53 (30.3%), 38 (21.7%), and 58 (33.1%) participants in the simple snoring, mild, moderate, and severe obstructive sleep apnea syndrome groups, respectively. Cardiovascular diseases were significantly different between the four groups ( p = 0.014). Mean platelet volume in severe obstructive sleep apnea syndrome group was significantly higher than in mild or moderate obstructive sleep apnea syndrome group and simple snoring group ( p < 0.05). Moreover, there was a positive correlation between mean platelet volume levels and apnea–hypopnea index ( r = 0.424; p < 0.001). The independent predictors of cardiovascular diseases in obstructive sleep apnea syndrome were age ( p < 0.001; odds ratio = 1.134; confidence interval: 1.072–1.2), body mass index ( p = 0.012; odds ratio: 1.105; confidence interval: 1.022–1.194), and mean platelet volume ( p < 0.001; odds ratio: 2.092; confidence interval: 1.386–3.158). Conclusion: The present study demonstrated that there is an association between mean platelet volume levels and cardiovascular diseases in patients with obstructive sleep apnea syndrome.

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Section: Discussionmentioning

confidence: 99%

Association between mean platelet volume and cardiovascular disease in obstructive sleep apnea syndrome

et al. 2023

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“…Previous studies have employed ultrasound-based methods as imaging techniques to visualize CBs or to detect and diagnose CB tumors in animals and in patients with hypertension, sleep apnea, and CB tumors 2,49,50 . In this report, we were able to identify the carotid bifurcation in the rat model, and ablate the CB using a DMUA system to localize the bifurcation as an anatomical marker.…”

Section: Discussionmentioning

confidence: 99%

Precision Targeted Ablation of Fine Neurovascular Structures In Vivo Using Dual-mode Ultrasound Arrays

Aravalli¹,

Helden

Liu³

et al. 2020

Sci Rep

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carotid bodies (cBs) are chemoreceptors that monitor and register changes in the blood, including the levels of oxygen, carbon dioxide, and pH, and regulate breathing. enhanced activity of cBs was shown to correlate with a significant elevation in the blood pressure of patients with hypertension. CB removal or denervation were previously shown to reduce hypertension. Here we demonstrate the feasibility of a dual-mode ultrasound array (DMUA) system to safely ablate the cB in vivo in a spontaneously hypertensive rat (SHR) model of hypertension. DMUA imaging was used for guiding and monitoring focused ultrasound (FUS) energy delivered to the target region. In particular, 3D imaging was used to identify the carotid bifurcation for targeting the cBs. intermittent, high frame rate imaging during image-guided fUS (igfUS) delivery was used for monitoring the lesion formation. DMUA imaging provided feedback for closed-loop control (cLc) of the lesion formation process to avoid overexposure. The procedure was tolerated well in over 100 SHR and normotensive rats that received unilateral and bilateral treatments. the measured mean arterial pressure (MAp) exhibited measurable deviation from baseline 2-4 weeks post IgFUS treatment. The results suggest that the direct unilateral FUS treatment of the CB might be sufficient to reduce the blood pressure in hypertensive rats and justify further investigation in large animals and eventually in human patients.

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“…В то же время ряд конечных точек принято считать биомаркерами старения, отражающими изменения внутренних органов (артериальная жесткость, толщина комплекса интима-медиа, минеральная плотность кости, уровень инсулин-подобного фактора роста и другие). Доказано неблагоприятное влияние СОАС на толщину комплекса интима-медиа артерий [44] и развитие атеросклероза [45], который принято рассматривать в качестве возрастной патологии. Известно, что изменение продолжительности сна, СОАС повышают сосудистую жесткость и таким образом связаны со старением [46,47].…”

Section: ускоренное старениеunclassified

What is important for an internist to know about sleep?

Grischenko

Bazhenova

Grishina

2023

jour

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Introduction. A variety of patient complaints about sleep disorders and associated quality of life restrictions force patients to turn primarily to internists. Meanwhile, internist doctors often pay insufficient attention to detailing the symptoms associated with the patient's sleep state. Main purpose of the work was to systematize modern data on the relationship between sleep disorders and pathology of internal organs and to increase the awareness of internists about sleep disorders and associated diseases. Materials and methods. Literature sources were selected for the review by the keywords: sleep, sleep disorders, OSAS for the period 2003–2021 in PubMed, GoogleScholar, Web of Science databases. Results and discussion. Disorders of sleep duration and quality in patients influence the development of other internal organ pathologies. Of particular importance is the relationship of sleep disorders with nocturnal cardiac rhythm and conduction disorders, changes in daily BP profile, OSAS, nocturnal heartburn and GERD, accelerated aging. Analysis of a patient's sleep status is of great importance in the practice of an internist and can improve the prognosis for a number of diseases. Conclusion. When working with patients, internists should assess the state of sleep as a potentially modifiable risk factor for diseases of the internal organs.

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Assessment of carotid artery intima‐media thickness in patients with obstructive sleep apnoea

Abstract: Automated measurement of the CIMT can be a useful tool for CVD risk assessment in patients with OSA. Severity of OSA may be an intermediate factor between multiple co-morbidities and carotid atherosclerotic change.

Cited by 9 publications

References 21 publications

Association between mean platelet volume and cardiovascular disease in obstructive sleep apnea syndrome

Association between mean platelet volume and cardiovascular disease in obstructive sleep apnea syndrome

Precision Targeted Ablation of Fine Neurovascular Structures In Vivo Using Dual-mode Ultrasound Arrays

What is important for an internist to know about sleep?

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