Assessment of causal association between thyroid function and lipid metabolism: a Mendelian randomization study

Wang, Jingjia; Zhuang, Zhenhuang; Shao, Chunli; Yu, Canqing; Wang, Wenyao; Zhang, Kuo; Meng, Xiaoxue; Gao, Jun; Tian, Jianwei; Zheng, Jilin; Huang, Tao; Tang, Yi‐Da

doi:10.1097/cm9.0000000000001505

Cited by 29 publications

(23 citation statements)

References 39 publications

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“…Thyroid diseases and T2D often coexist in the same patients, reinforcing the hypothesis of a reciprocal relationship between these two disorders [9,[98][99][100]. Indeed, THs exert a series of effects on glucose metabolism, as suggested by the action of THs on the pancreas in modulating the development and function of pancreatic β-cells [101,102].…”

Section: Thyroid and Type 2 Diabetesmentioning

confidence: 83%

“…Furthermore, T3 can exert central effects through critical intrahypothalamic actions, with a significant impact on hepatic glucose-production and insulin sensitivity [105]; moreover, it regulates the expression of genes involved in hepatic metabolic responses such as gluconeogenesis, lipogenesis, insulin signaling, adenylate cyclase signaling, cell proliferation, and apoptosis [106,107]. THs may also indirectly lead to T2D complications, as they are positively associated with central adiposity and cardiometabolic risk factors, including increased blood pressure and dyslipidemia [100,108].…”

Section: Thyroid and Type 2 Diabetesmentioning

confidence: 99%

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Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

Gorini

Vassalle

2022

Antioxidants

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Type 2 diabetes (T2D) is considered one of the largest global public-health concerns, affecting approximately more than 400 million individuals worldwide. The pathogenesis of T2D is very complex and, among the modifiable risk factors, selenium (Se) has recently emerged as a determinant of T2D pathogenesis and progression. Selenium is considered an essential element with antioxidant properties, and is incorporated into the selenoproteins involved in the antioxidant response. Furthermore, deiodinases, the enzymes responsible for homeostasis and for controlling the activity of thyroid hormones (THs), contain Se. Given the crucial action of oxidative stress in the onset of insulin resistance (IR) and T2D, and the close connection between THs and glucose metabolism, Se may be involved in these fundamental relationships; it may cover a dual role, both as a protective factor and as a risk factor of T2D, depending on its basal plasma concentration and the individual’s diet intake. In this review we discuss the current evidence (from experimental, observational and randomized clinical studies) on how Se is associated with the occurrence of T2D and its influence on the relationship between thyroid pathophysiology, IR and T2D.

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Section: Thyroid and Type 2 Diabetesmentioning

confidence: 83%

Section: Thyroid and Type 2 Diabetesmentioning

confidence: 99%

Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

Gorini

Vassalle

2022

Antioxidants

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“…The arrhythmia of hyperthyroidism may be mainly due to the upregulation of hyperdynamic circulation, cardiac structural and functional proteins, ion channels, and gap junction proteins (20)(21)(22). Hypothyroidism is associated with a variety of cardiovascular risk factors, such as metabolic syndrome, obesity, hypertensive heart disease, diabetes, and oxidative stress, which in turn can lead to atrial fibrillation (23)(24)(25). Hypothyroidism can reduce heart rate, prolong the atrial effective refractory period, increase atrial collagen in hypothyroid animals, and promote myocardial fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Association Between Thyroid Dysfunction and Incidence of Atrial Fibrillation in Patients With Hypertrophic Obstructive Cardiomyopathy

et al. 2022

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ObjectiveTo explore the correlation between the incidence of atrial fibrillation (AF) and thyroid dysfunction in patients with hypertrophic obstructive cardiomyopathy (HOCM).MethodsThyroid function testing in 755 consecutive patients with HOCM were examined at the National Center for Cardiovascular Diseases (China) from October 2009 to December 2013. Patients were divided into four groups according to the TSH levels: TSH<0.55 mIU/L(n=37)、0.55~2.49 mIU/L (n=490)、2.50~9.9 mIU/L (n=211) and >10.00mIU/L(n=17).ResultsA total of 107 patients were diagnosed with AF (14%).(1) Compared to HOCM patients without AF,HOCM patients with AF have older age (P<0.001), higher NT-proBNP (P=0.002), higher Cr (P=0.005), larger left atrial diameter(P=0.001), lower FT3 (P=0.046), higher FT4 (P=0.004).(2) In the four groups according to the TSH levels: TSH<0.55 mIU/L, 0.55~2.49mIU/L, 2.50~9.9mIU/L and ≥10.00mIU/L, the incidence of AF was 27.02%(10/37),10.20%(50/490), 19.43%(41/211), and 35.29%(6/17), respectively. Both high and low TSH levels were associated with an increased incidence of AF. After adjusting for the common risk factor (age, NT-proBNP, and so on), stepwise multiple logistic regression analysis revealed that TSH levels were significantly related to AF incidence.Compared to patients with TSH 0.55~2.49 mlU/L, the adjusted odds ratio of AF for TSH<0.55, 2.50~9.99, ≥10.00 mIU/L were 1.481 (95% CI 0.485~4.518,P=0.490), 1.977 (95%CI 1.115~3.506, p=0.02), 4.301 (95%CI 1.059~17.476, P=0.041), respectively.ConclusionOur results suggested that thyroid dysfunction was associated with an increased risk of AF in patients with HOCM.

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“…Thus, they are consequently highly associated with lipid accumulation. 19,20 TH was reported to have positive effects on hyperplastic growth of brown adipose tissue (BAT) 21,22 and can induce the browning of white adipose tissue (WAT), 23 a process of inducing a phenotypic transition from energy-storing WAT to thermogenic BAT. 22,24,25 Moreover, TH treatment can decrease oxidative stress and inflammasome activation, increase fatty acid oxidation, and decrease lipid accumulation in mice.…”

Section: ■ Introductionmentioning

confidence: 99%

Dietary Methionine Restriction Promotes Fat Browning and Attenuates Hepatic Lipid Accumulation in High-Choline-Fed Mice Associated with the Improvement of Thyroid Function

Yang

Qian

et al. 2023

J. Agric. Food Chem.

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This study aims to explore the influences of a methionine-restricted diet (MRD) on fat browning and hepatic lipid accumulation in mice fed with a high-choline diet (HCD) and their possible mechanisms. ICR mice were randomly divided into three groups and fed with a normal diet (0.86% methionine + 0.20% choline, ND), HCD (0.86% methionine + 1.20% choline), or MRD (0.17% methionine + 1.20% choline) for 90 consecutive days. We found that MRD reduced body weight and fat mass; increased heat production and ambulatory locomotor activity; reduced hepatic and plasma lipid levels, hepatic fatty infiltration area, and adipocyte volume in white and brown adipose tissue; promoted fat browning, especially upregulated gene and protein expression levels of uncoupling protein 1 (UCP1); and promoted fat catabolism and inhibited fat anabolism in the liver and adipose tissue. Moreover, MRD increased antioxidant defenses and reduced inflammatory cytokine levels in the thyroid, blood, and liver. Furthermore, MRD improved thyroid morphological structure, promoted the synthesis and secretion of thyroid hormones, and enhanced the actions of thyroid hormones on its receptor organs (liver and adipose tissue). These findings suggested that MRD promoted fat browning and attenuated hepatic lipid accumulation in HCD mice associated with the improvement of thyroid function.

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Assessment of causal association between thyroid function and lipid metabolism: a Mendelian randomization study

Abstract: Supplemental Digital Content is available in the text

Cited by 29 publications

References 39 publications

Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

Association Between Thyroid Dysfunction and Incidence of Atrial Fibrillation in Patients With Hypertrophic Obstructive Cardiomyopathy

Dietary Methionine Restriction Promotes Fat Browning and Attenuates Hepatic Lipid Accumulation in High-Choline-Fed Mice Associated with the Improvement of Thyroid Function

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