Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles

Abstract

Aim Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm.

Primordial odontogenic tumor: An immunohistochemical profile

“…3a,b). This situa-tion may be explained by the fact that CD-105 expression, contrary to CD34, is a characteristic property of newly formed blood vessels and not of previously-existing blood and lymphatic vessels (34). CD 105 in POT was found mainly in blood vessels located in the areas of greater condensation of mesenchymal cells, particularly in the subepithelial region, thus signaling neoangio-genesis activity in this tumoral area (Fig.…”

Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas

“…Different studies performed by our group ( 14 , 28 , 29 ) have shown that the growth of the odontogenic myxoma is the product of a complex multifactorial process in which cell proliferation and angiogenesis are involved mainly in the early stages. With the present results, we suggest that the growth of these neoplasms can also be related with the production and performance of different mechanisms related with the RANK / RANK-L / OPG system.…”