Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalisL.), Turmeric (Curcuma longaL.), and Ginger (Zingiber officinaleR.) Essential Oils in Cervical Cancer Cells (HeLa)

Santos, Paula A.S.R. Dos; Avanço, Geleys Brado; Nerilo, Samuel Botião; Marcelino, R. I. A.; Janeiro, Vanderly; Valadares, Marize Campos; Machinski, Miguel

doi:10.1155/2016/9273078

Cited by 35 publications

(21 citation statements)

References 25 publications

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“…TPG was demonstrated to be non-mutagenic in the bacterial reverse mutation test (Ames test) and negative for clastogenicity and aneugenicity in the in vitro mammalian cell micronucleus test. Cytotoxicity observed in both tests was not associated with any genotoxic activity; on the contrary, in vitro cytotoxicity of turmeric and other botanical extracts may be attributed to their potential use as anticancer agents (Santos et al, 2016).…”

Section: Pathologymentioning

confidence: 75%

“…Cytotoxicity observed in both tests was not associated with any genotoxic activity; on the contrary, in vitro cytotoxicity of turmeric and other botanical extracts may be attributed to their potential use as anticancer agents (Santos et al, 2016). Cytotoxicity observed in both tests was not associated with any genotoxic activity; on the contrary, in vitro cytotoxicity of turmeric and other botanical extracts may be attributed to their potential use as anticancer agents (Santos et al, 2016).…”

Section: Discussionmentioning

confidence: 89%

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Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Phipps

Quesnot²,

Privat³

et al. 2019

J of Applied Toxicology

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Turmeric (Curcuma longa L.) extracts have a long history of use worldwide, but a major limitation of these extracts is their extremely low oral bioavailability, caused by low absorption, rapid metabolism and rapid excretion following ingestion. Thus, a new highly bioavailable turmeric extract formulation (comprising turmeric extract, acacia gum, sunflower oil and quillaia extract) has been developed and is intended for use as a food ingredient. Safety of this novel extract was evaluated using the standard Tier 1 battery of in vitro genotoxicity tests (bacterial reverse mutation test and an in vitro mammalian cell micronucleus test) followed by repeated‐dose 28‐ and 90‐day oral toxicity studies in rats. In the 90‐day study, male and female Sprague‐Dawley rats were dosed once daily, by oral gavage, either with the vehicle or the test item at 500, 1500 or 3000 mg/kg body weight/day. Clinical examinations were conducted regularly, and body weights and food consumption were recorded weekly throughout the study. At the end of the study, blood samples were analyzed for clinical pathology parameters, before a macroscopic necropsy was conducted and a full list of tissues were examined histopathologically. There was no evidence of genotoxicity in vitro. No test item‐related adverse effects were observed in the 28‐ or 90‐day studies; therefore, 3000 mg/kg body weight/day (the maximum feasible dose and highest dose tested in rats) was established as the no‐observed‐adverse‐effect level.

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Section: Pathologymentioning

confidence: 75%

Section: Discussionmentioning

confidence: 89%

Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Phipps

Quesnot²,

Privat³

et al. 2019

J of Applied Toxicology

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“…(2017) ; Rivera et al. (2017) ; Wang et al., 2017 , Wang et al., 2017 ; Zhou et al., 2016 ; Santos et al. (2016) ; Liu et al.…”

Section: Resultsmentioning

confidence: 99%

Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria

Malami

Jagaba

Abubakar

et al. 2020

Heliyon

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This study was designed to explore and record various medicinal plants integrated into the traditional system of medicine for the treatment of cancer. The traditional system of medicine is a routine practiced among the indigenous ethnic groups of Sokoto state. A semi-structured questionnaire was designed and used for data collection around the selected Local Government Areas. A substantial number of plant species were identified, recorded, and collected for preservation. Data collected for each specie was analysed to assess its frequent use among the medicinal plants. A total of 67 species belonging to 31 families have been identified and recorded. Out of the 473 frequency of citation (FC), Acacia nilotica was the most frequently cited specie (32 FC, 64% FC, 0.6 RFC), followed by Guiera senegalensis (27 FC, 54% FC, 0.5 RFC), Erythrina sigmoidea (17 FC, 34% FC, 0.3 RFC), and subsequently Combretum camporum (15 FC, 30% FC, 0.3 RFC). The most common parts of the plants used include the barks (55.2%), the roots (53.2%), and the leaves (41.8%). Additionally, decoction (74.6%), powdered form (49.3%), and maceration (46.3%) are the most frequently used mode of preparation. The historical knowledge of a traditional system of medicine practiced by the native traditional healers of Sokoto for the treatment of cancer has been documented. The present study further provides a baseline for future pharmacological investigations into the beneficial effects of such medicinal plants for the treatment of cancer.

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“…The anti-proliferative effects of ginger essential oil against HeLa cervical cancer cells are created by cell membrane protrusions, blebbing and chromatin condensation. Increasing the concentration of ginger essential oil to 1928 μl/ml caused the amorphous cells, blebbing and chromatin condensation, which finally caused cell death by apoptosis, similar to those of camptothecin [44]. In other preclinical study, 10 μl/day ginger essential oil for 14 days on acid soluble sulfhydryl levels and hepatic carcinogen metabolizing enzymes (cytochrome P450, aryl hydrocarbon hydroxylase and glutathione-S-transferase) in Swiss albino mice showed that ginger essential oil significantly increased aryl hydrocarbon hydroxylase and glutathione-S-transferase [45].…”

Section: Anticancer Effects Of Ginger Essential Oilmentioning

confidence: 91%

Zingiber officinale Rosc. essential oil, a review on its composition and bioactivity

Mahboubi¹

2019

Clin Phytosci

134

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Zingiber officinale Rosc. is widely used as spice and medicinal plant in folk and traditional medicines. The aim of this study was to review the chemical composition and biological activities of Z. officinale (ginger) essential oil. Ginger oil is extracted from Z. officinale rhizomes, which its chemical composition influences from geographical region, extraction methods, freshness or dryness of rhizomes. The antibacterial, antifungal, analgesic, anti-inflammatory, anti-ulcer, immunomodulatory, relaxant, and warming effects of ginger oil have been confirmed in experimental and preclinical studies. The safety issues of ginger oils are well documented and are generally regarded as safe. Due to wide pharmacological effects of ginger oil, attention to ginger oil as an ingredient of natural formulations in management of gastrointestinal and respiratory diseases is valuable.

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Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalisL.), Turmeric (Curcuma longaL.), and Ginger (Zingiber officinaleR.) Essential Oils in Cervical Cancer Cells (HeLa)

Cited by 35 publications

References 25 publications

Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria

Zingiber officinale Rosc. essential oil, a review on its composition and bioactivity

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