Assessment of cytotoxicity of choline chloride-based natural deep eutectic solvents against human HEK-293 cells: A QSAR analysis

Deep Eutectic Solvents as Extraction Media for Valuable Flavonoids from Natural Sources

“…The results indicated that although no clear trend regarding cytotoxicity in relation with structure was observed, the presence of organic acids as HBDs results in increased cytotoxic activity. A series of 28 NaDES containing ChCl as the HBA and a variety of HBDs were tested for their cytotoxicity against the human embryonic kidney cell line (HEK-293) [27]. The results showed that ChCl, as well as the compounds used as HBDs, were less toxic than the corresponding NaDES and that the structure of the HBD and the HBA/HBD ratio play a role in cytotoxicity.…”

Non-volatile conductive gels made from deep eutectic solvents and oxidised cellulose nanofibrils

“…17 However, as with any chemical, cytotoxicity varies signicantly depending on concentration, cells tested against, and the specic combination of components and this would have to be taken into consideration for any clinical applications. 16,17,[43][44][45] We found good gel formation with tuneable properties and straightforward synthesis.…”

Use of Deep Eutectic Solvents in the Treatment of Agro-Industrial Lignocellulosic Wastes for Bioactive Compounds

“…Additionally, they reported that a trend could be observed between the cytotoxicity profile and the viscosity, the water content, and the nature of the components of NADESs. Ahmadi et al [124] presented a research on the assessment of the cytotoxicity of 28 NADESs (HBA: ChCl, HBDs: ethylene glycol, glycerol, 1,2-propanediol, sorbitol, xylitol, xylose, fructose, glucose, mannose, glucosamine, sucrose, maltose, rhamnose, raffinose) by using quantitative structure activity relationship analysis. According to their findings, an increase in the glycerol molar ratio decreased the toxic effect of NADES, whereas an increase in the 1,2-propanediol molar ratio increased the toxic effect.…”