Assessment of dental implant surface stability at the nanoscale level

Labis, Varvara; Bazikyan, E. A.; Жигалина, О. М.; Сизова, С. В.; Oleinikov, Vladimir; Khmelenin, D. N.; Dyachkova, I. G.; Золотов, Д. А.; Бузмаков, А. В.; Асадчиков, В. Е.; Хайдуков, С. В.; Kozlov, Ivan

doi:10.1016/j.dental.2022.03.003

Cited by 8 publications

(13 citation statements)

References 19 publications

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“…There was no significant difference between the first day and the 30th day; however, gathering nanoparticles were decreased in morphology by approximately the 60th day and a section of the gelatin matrix had been removed. Labias et al reported that a carbon nanostructure coating has a different dispersion on dental implants in the different sections of the implant [ 36 ]. Of course, the difference between our research and this group is that coated healing has been carried out in the current study.…”

Section: Discussionmentioning

confidence: 99%

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Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Dizaj

Torab

Kouhkani

et al. 2023

Clinics and Practice

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Regarding the importance of preventing peri-implantitis in dental implants, the current study aimed to coat a healing abutment with gelatin–curcumin nanocomposites, and the stability of this coating on the healing abutment was evaluated. A cell viability measuring test was used to determine the cytotoxicity of nanocomposites against dental pulp stem cells. To show the pattern of curcumin release from nanocomposites, drug dissolution apparatus two was applied. Then, 16 healing abutments were examined in vitro. Titanium healing abutments were coated with the gelatin–curcumin nanocomposite. The dip coating method was applied for coating and the consistency of coated cases was evaluated at intervals of one, 30, and 60 days after coating inside the simulated body fluid (SBF) solution. A scanning electron microscope (SEM) was used for investigating the microstructure and morphology of coatings, and an energy dispersive X-ray (EDX) was applied for determining the combination of the coating. Moreover, the healings were weighed before and after coating via an accurate digital scale with an accuracy of 0.0001. Finally, the data were analyzed using SPSS software. The prepared nanocomposite was non-cytotoxic against tested cells. The nanocomposite showed a relatively rapid release pattern in the first 10 days for curcumin. The release of curcumin from the nanoparticles continued slowly until the 30th day. The weight changes were statistically significant (p-value < 0.001) during this time. Based on the post hoc test, the weight between two times immediately after coating and 30 days after coating, and also one day after coating and 30 days after coating, was statistically insignificant. The results revealed that the coating of the gelatin–curcumin nanocomposite on the healing was successful and this consistency was kept for at least one month. It is necessary to investigate more evaluations in different fields of physicochemical, mechanical, and antimicrobial aspects for coated healing abutments.

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Section: Discussionmentioning

confidence: 99%

“…The element analysis result of Labias et al showed that element distribution percentages are different in various sections of the implant. The reasons for the difference can be differences in the used substances, differences in the coating method, and differences in the used implant [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Dizaj

Torab

Kouhkani

et al. 2023

Clinics and Practice

View full text Add to dashboard Cite

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“…The method of dynamic light scattering (photon correlation or quasi-elastic light scattering) can be used to measure objects from 1 nm to 10 µm in size, which allowed us to detect the yield of NSMP and MSMP (microscale metal particles) from the objects of this study [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…During the second orthopedic stage in the classical technique of dental implantation, the appearance of a functional load facilitates the release of nanoparticles and the formation of microparticles [ 17 ]. Presumably, over time, there is a disruption of the immune system’s tolerance and activation of antibody synthesis caused by the accumulation of a critical mass of particles, the early death of immunocompetent cells and the onset of endogenous infection.…”

Section: Introductionmentioning

confidence: 99%

Immunopathological Inflammation in the Evolution of Mucositis and Peri-Implantitis

Labis

Bazikyan

Сизова

et al. 2022

IJMS

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The purpose of this study was to provide an immuno-mediated substantiation of the etiopathogenesis of mucositis and peri-implantitis based on the results of experimental, laboratory and clinical studies. The biopsy material was studied to identify impregnated nanoscale and microscale particles in the structure of pathological tissues by using X-ray microtomography and X-ray fluorescence analyses. Electron microscopy with energy-dispersive analysis identified the composition of supernatants containing nanoscale metal particles obtained from the surfaces of dental implants. The parameters of the nanoscale particles were determined by dynamic light scattering. Flow cytometry was used to study the effect of nanoscale particles on the ability to induce the activation and apoptosis of immunocompetent cells depending on the particles’ concentrations during cultivation with the monocytic cell line THP-1 with the addition of inductors. An analysis of the laboratory results suggested the presence of dose-dependent activation, as well as early and late apoptosis of the immunocompetent cells. Activation and early and late apoptosis of a monocytic cell line when THP-1 was co-cultured with nanoscale metal particles in supernatants were shown for the first time. When human venous blood plasma was added, both activation and early and late apoptosis had a dose-dependent effect and differed from those of the control groups.

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“…Cell reactions directly depend on the chemical and physical characteristics of the implant, in particular, on the particle size, chemical composition, and surface morphology, as well as on the geometry of internal and external threads [3]. Human mesenchymal stem cells have poor adhesion to a smooth titanium surface; this can lead to the formation of a fibrous tissue layer between the implant and the surrounding bone, and, thus, to the process of fibro-osseous integration with subsequent development of mucositis and peri-implantitis with a loss of the dental implants [4,5]. Multiple modifications to the implant surface were proposed to solve this problem and to increase the biocompatibility, as well as the cell viability; the said modifications affect the topography, roughness characteristics, and surface layer chemical composition [6,7].…”

Section: Introductionmentioning

confidence: 99%

Impact of Sandblasting and Plasma Electrolytic Oxidation on Surface Quality of Dental Implants

Zaynullina,

Farrakhov,

Ramazanov

et al. 2023

Sovrem Tehnol Med

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Titanium alloys have high biocompatibility, and, therefore, they are widely used in the production of implantable medical devices. Implants, in turn, must have certain surface properties for a positive osseointegration. To improve biocompatibility, as well as cell viability, numerous implant surface modifications have been proposed in order to improve topography, roughness parameters, and surface layer chemical and phase compositions.The most common type of surface treatment for dental implants involves sandblasting with aluminum oxide Al 2 O 3 (corundum). However, aluminum is not a biocompatible element, and it can contribute to development of various diseases. Currently, the method of plasma electrolytic oxidation is being actively developed to ensure formation of a biocompatible TiO 2 -based oxide coating on the surface of titanium implants.The aim of the study was to establish the residual aluminum content in the surface layer of dental implants after sandblasting and subsequent plasma electrolytic oxidation to justify the effective process sequence in serial production of dental implants.Materials and Methods. The research was conducted to establish the residual content of aluminum in the surface layer of the NCTi implant subjected to two surface treatment methods: sandblasting and plasma electrolytic oxidation following the sandblasting.Results. Sandblasting with Al 2 O 3 particles leads to fixation of such particles with Al weight fraction of 2.67±0.79% in the surface layer of the implant. Treatment of a dental implant using plasma electrolytic oxidation helps to reduce the Al weight fraction in the surface layer to 0.33±0.08% and significantly improves the implant corrosion resistance with a decrease in corrosion currents by an order of magnitude.

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Assessment of dental implant surface stability at the nanoscale level

Cited by 8 publications

References 19 publications

Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Gelatin–Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation

Immunopathological Inflammation in the Evolution of Mucositis and Peri-Implantitis

Impact of Sandblasting and Plasma Electrolytic Oxidation on Surface Quality of Dental Implants

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