Assessment of depression in subjects with psoriasis vulgaris and lichen planus

Akay, Aynur Pekcanlar; Pekcanlar, Aynur Akay; Bozdag, KE; Altıntaş, Levent; Karaman, Ahmet

doi:10.1046/j.1468-3083.2002.00467.x

Cited by 141 publications

(142 citation statements)

References 15 publications

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“…Another study showed 53% depression in OLP patients and 20% in control group by "Beck Depression Score". This study confirmed importance of depression assessment in skin diseases like lichen planus and psoriasis [17]. Hampf et al, [18] showed OLP lesions became worse during times of mental stress, but most patients did not feel any need for psychiatric treatment.…”

Section: Discussionsupporting

confidence: 78%

Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients

Nadendla

Venkateswarlu

Paramkusam

et al. 2014

JCDR

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Background: Oral lichen planus (OLP) is a frequently encoun tered chronic inflammatory disease of oral mucosa and skin, where the patients often relate the onset and aggravation of oral symptoms to increased levels of stress. Cortisol, also called as "stress hormone" has been used as an indicator in various stress evaluation studies. Aim:The aim of this crosssectional study was to determine any association between anxiety and salivary cortisol levels in OLP patients. Materials and Methods:A total of 20 OLP patients along with same number of age and sex matched healthy controls were included in the study. Saliva was collected from all the subjects between 9.00 to 9.15 am to avoid diurnal variations of cortisol levels. The saliva samples were analysed for cortisol levels by competitive enzymelinked immunosorbent assay (ELISA) method. Anxiety levels of 40 patients were measured by using Hamilton's anxiety scale. Student's ttest was used to compare the anxiety and salivary cortisol levels between both groups. Results:The mean salivary cortisol level of the OLP group showed highly significant difference (p<0.001) from the controls. The mean anxiety scores of the OLP group showed highly significant difference (p<0.001) from the controls. A positive correlation was found between anxiety and salivary cortisol levels in the OLP patients. Conclusion:These findings suggest that anxiety play a vital role in the pathogenesis of OLP, thus besides traditional treatment, psychological support is also needed.

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Section: Discussionsupporting

confidence: 78%

Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients

Nadendla

Venkateswarlu

Paramkusam

et al. 2014

JCDR

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“…They might also be concerned about the outcome of illness, use of more toxic drugs, and hospital admissions in the course of illness. This finding was supported by a study conducted by Lakshmy et al, 21 Devrimci-Qzguven et al, 25 Akay et al, 26 which found a direct corelation between the severity of psoriasis with the depressive score. This study did not demonstrate statistically significant association of severity of skin lesions (PASI score) with anxiety score and QOL score in psoriasis cases with GHQ score ≥3, even though a trend of more anxiety and poorer QOL in cases with severe skin lesions was evident.…”

Section: Discussionsupporting

confidence: 57%

Psychiatric Morbidity and Quality of Life in Patients suffering from Psoriasis in a Tertiary Care Hospital

Kumar¹,

Shrivastava²,

Jaiswal³

et al. 2017

International Journal of Advanced and Integrated Medical Sciences

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Introduction: Psoriasis is an inflammatory skin disease, which may be persistent, disfiguring, and stigmatizing. The disease is frequent, with prevalence estimates ranging from 0.3 to 2.5%. It is characterized by thick, red, scaly lesion that may appear on any part of the body. Psoriasis is associated with significant psychological and psychiatric morbidity, experience of stigmatization, and decreased health-related quality of life (QOL).

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“…However, here is controversy over the role of stress as a possible etiologic factor in OLP (4,6,7); some studies have already been carried out on the role of psychiatric disorders and stress as etiologic factors in oral lichen planus. The vast majority of these studies have used Hamilton Anxiety Scale (HAS) and Hamilton Depression Scale (HDS) and Beck Depression Score (BDS) to compare anxiety and depression level of the patients suffering from OLP with a control group consisting of healthy subjects and some have detected a higher level of stress and depression in patients suffering from OLP (4,7,9). However, these studies were not interventional studies.…”

Section: Discussionmentioning

confidence: 99%

“…Such stressors consisted of family members' disease, financial or legal problems, cancerophobia, and family disagreements (a second marriage of the husband, marriage of children despite parents' opposition, lack of understanding between spouses), loneliness, worries concerning childbirth, accidents, assault and battery and death of family members and relatives. However, some studies have demonstrated that stress may not result in OLP development but OLP may alter the individual's self-image and influence his/ her public relations and lead to secondary depression (4). Some other studies have failed to establish a direct cause-and-affect relationship between psychiatric disorders and lichen planus (6).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, any factor that can influence the cell-mediated immune response can have a role in the development of the disease. Factors such as stress and psychological problems, especially depression and anxiety, have been mentioned as etiologic factors in lichen planus but there is still controversy concerning the role of stress as a major or minor etiologic factor in the pathogenicity of lichen planus (4)(5)(6)(7). The correlation of this disease and psychiatric disorders has been studied, but no research into the effect of psychiatric therapy on oral lichen planus patients has been carried out to date.…”

Section: Introductionmentioning

confidence: 99%

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The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorders

Delavarian¹,

Javadzadeh-Bolouri²,

Dalirsani³

et al. 2010

Med Oral

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http://www.medicinaoral.com/medoralfree01/v15i2/medoralv15i2p322.pdf AbstractObjectives: Current treatments of oral lichen planus are palliative, not curative. Because psychiatric disorders significantly influence the development and severity of oral lichen planus, the use of psychiatric drug therapy may be an adjunct in treatment. The purpose of this study was to determine the efficacy of drug therapy of psychiatric disorders in oral lichen planus. Study design: Our controlled clinical study consisted of forty-six patients with oral lichen planus and psychiatric disorders who were randomly divided into two groups. Both groups were given topical corticosteroids and the study group received additional psychiatric drug therapy. Patients were monitored for a period of 6 months. Response to treatment was evaluated in each group and was compared with the other group using Mann-Whitney tests. We evaluated the correlation between psychiatric disorders and the recovery of oral lesions using Spearman's correlation coefficient analysis. Results: Decrease in the size of the lesions was significantly greater in the study group after six months, but this difference was not significant in relationship to the pain experienced and the kind of lesion. Spearman's correlation coefficient analysis demonstrated that, in the sixth month, there was a significant and direct relationship between recovery from the psychiatric disorders and response to treatment of OLP lesions, particularly as it pertained to the kind of lesion. Conclusion: The present study indicates that the combination of psychiatric drug therapy and routine treatment methods were effective in reducing the size of the lesions, but did not have any significant effect on the symptoms.

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Assessment of depression in subjects with psoriasis vulgaris and lichen planus

Abstract: This study confirms the importance of depressive symptoms in two common dermatological diseases. It is important to recognize this association as it affects both clinical outlook and response to treatment.

Cited by 141 publications

References 15 publications

Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients

Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients

Psychiatric Morbidity and Quality of Life in Patients suffering from Psoriasis in a Tertiary Care Hospital

The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorders

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