Assessment of EDTA in Chromium (III–VI) Toxicity on Marine Intertidal Crab (Petrolisthes laevigatus)

Urrutia, Carolina; Rudolph, Anny; Lermanda, María Paz; Ahumada, Ramón

doi:10.1007/s00128-007-9310-8

Cited by 17 publications

(6 citation statements)

References 12 publications

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“…The toxicity of Cr 2 O 3 is lower than that of hexavalent chromium (Cr(VI)) compounds such as CrO 3 , which is water soluble and a strong oxidant (Barceloux,1999; Hininger et al,2007; Urrutia et al,2008). There have been many investigations focusing on the carcinogenicity of hexavalent chromium (De Flora and Wetterhahn,1989; Holmes et al,2008).…”

Section: Introductionmentioning

confidence: 99%

Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells

Horie

Nishio

Endoh³

et al. 2011

Environmental Toxicology

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Chromium(III) oxide (Cr(2)O(3)) is used for industrial applications such as catalysts and pigments. In the classical form, namely the fine particle, Cr(2)O(3) is insoluble and chemically stable. It is classified as a low-toxicity chromium compound. Recently, industrial application of nanoparticles (a new form composed of small particles with a diameter of ≤100 nm, in at least one dimension) has been increasing. Cellular effects induced by Cr(2)O(3) nanoparticles are not known. To shed light upon this, the release of soluble chromium from Cr(2)O(3) nano- and fine-particles in culture medium was compared. Fine Cr(2)O(3) particles were insoluble in the culture medium; on the contrary, Cr(2)O(3) nanoparticles released soluble hexavalent chromium into the culture medium. Cr(2)O(3) nanoparticles showed severe cytotoxicity. The effect of Cr(2)O(3) nanoparticles on cell viability was higher than that of fine particles. Cr(2)O(3) nanoparticles showed cytotoxicity equal to that of hexavalent chromium (K(2)Cr(2)O(7)). Human lung carcinoma A549 cells and human keratinocyte HaCaT cells showed an increase in intracellular reactive oxygen species (ROS) level and activation of antioxidant defense systems on exposure to Cr(2)O(3) nanoparticles. Exposure of Cr(2)O(3) nanoparticles led to caspase-3 activation, showing that the decrease in cell viability by exposure to Cr(2)O(3) nanoparticles was caused by apoptosis. Cellular responses were stronger in the Cr(2)O(3) nanoparticles-exposed cells than in fine Cr(2)O(3) - and CrCl(3) -exposed cells. Cellular uptake of Cr(2)O(3) particles were observed in nano- and fine-particles. The cellular influence of the extracellular soluble trivalent chromium was lower than that of Cr(2)O(3) nanoparticles. Cr(2)O(3) nanoparticles showed cytotoxicity by hexavalent chromium released at outside and inside of cells. The cellular influences of Cr(2)O(3) nanoparticles matched those of hexavalent chromium. In conclusion, Cr(2)O(3) nanoparticles have a high cytotoxic potential.

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Section: Introductionmentioning

confidence: 99%

Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells

Horie

Nishio

Endoh³

et al. 2011

Environmental Toxicology

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“…No significant differences were observed with Cr (III) + EDTA as compared with untreated controls. Cr (VI) toxicity was greater than of Cr (III), with low individual survival rates [47].…”

Section: Chromiummentioning

confidence: 92%

Marine Invertebrates as Bioindicators of Heavy Metal Pollution

Chiarelli¹,

Roccheri²

2014

OJMetal

125

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Atmosphere, earth and water compose the environment. The presence of heavy metals in the environment has grown because of their large employment in some industrial and agricultural activities. Although these metals are terrestrial products, they flow into the sea through effluents and sewage or are directly discharged from industries placed on the seawater front. It should be considered that metals concentrations vary widely according to different seawater latitudes and depths and can be strongly influenced by fresh water discharges from heavily polluted rivers. In this review recent studies on heavy metal pollution in marine ecosystems and their organisms will be presented. Metal speciation, bioaccumulation in biota, as well as abiotic and biotic factors affecting their bioavailability will be reviewed. Moreover, the use of bioindicator organisms for the biomonitoring of heavy metal toxicity and their ecological effects will be defined. Many marine invertebrate species fulfill the following criteria: Sensitivity to a wide range of chemicals (especially to heavy metals), cost-effectiveness for repeatable tests, readily interpretable biological consequences of pollution. Among the most important marine invertebrates used as bioindicators, the sea urchin embryo is one of the most suitable, especially to assess metal/heavy metal pollution.

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“…Excess amounts of ROS can cause cell death by damaging DNA and RNA, inactivating enzymes, oxidizing proteins, and causing lipid peroxidation ( Srivastava et al., 2021 ). Despite this fact, it has been found that Cr (III) is less harmful than Cr (VI), and animals need it to maintain their metabolic processes ( Mohan and Pittman Jr, 2006 ; Urrutia et al., 2008 ). There is contradictory evidence from different research studies, on whether or not Cr is essential for plant metabolism.…”

Section: Introductionmentioning

confidence: 99%

Systems biology of chromium-plant interaction: insights from omics approaches

Abdullah,

Wani,

Naeem

et al. 2024

Front. Plant Sci.

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Plants are frequently subjected to heavy metal (HM) stress that impedes their growth and productivity. One of the most common harmful trace metals and HM discovered is chromium (Cr). Its contamination continues to increase in the environment due to industrial or anthropogenic activities. Chromium is severely toxic to plant growth and development and acts as a human carcinogen that enters the body by inhaling or taking Cr-contaminated food items. Plants uptake Cr via various transporters, such as sulfate and phosphate transporters. In nature, Cr is found in various valence states, commonly Cr (III) and Cr (VI). Cr (VI) is soil’s most hazardous and pervasive form. Cr elevates reactive oxygen species (ROS) activity, impeding various physiological and metabolic pathways. Plants have evolved various complex defense mechanisms to prevent or tolerate the toxic effects of Cr. These defense mechanisms include absorbing and accumulating Cr in cell organelles such as vacuoles, immobilizing them by forming complexes with organic chelates, and extracting them by using a variety of transporters and ion channels regulated by various signaling cascades and transcription factors. Several defense-related proteins including, metallothioneins, phytochelatins, and glutathione-S-transferases aid in the sequestration of Cr. Moreover, several genes and transcriptional factors, such as WRKY and AP2/ERF TF genes, play a crucial role in defense against Cr stress. To counter HM-mediated stress stimuli, OMICS approaches, including genomics, proteomics, transcriptomics, and metallomics, have facilitated our understanding to improve Cr stress tolerance in plants. This review discusses the Cr uptake, translocation, and accumulation in plants. Furthermore, it provides a model to unravel the complexities of the Cr-plant interaction utilizing system biology and integrated OMICS approach.

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Assessment of EDTA in Chromium (III–VI) Toxicity on Marine Intertidal Crab (Petrolisthes laevigatus)

Cited by 17 publications

References 12 publications

Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells

Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells

Marine Invertebrates as Bioindicators of Heavy Metal Pollution

Systems biology of chromium-plant interaction: insights from omics approaches

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