Assessment of Endothelial Function in Alzheimer's Disease: Is Alzheimer's Disease a Vascular Disease?

Dede, Didem Şener; Yavuz, Bünyamin; Yavuz, Burcu Balam; Cankurtaran, Mustafa; Halil, Meltem; Ülger, Zekeriya; Cankurtaran, Eylem Şahin; Aytemir, Kudret; Kabakçı, Giray; Arıoğul, Servet

doi:10.1111/j.1532-5415.2007.01378.x

Cited by 119 publications

(108 citation statements)

References 28 publications

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…Therefore, the only independent factor that causes damage in endothelial function was advanced age. It has been proved that endothelial dysfunction occurs in many diseases including chronic renal failure, heart failure, hypertension, diabetes mellitus, hypercholesterolemia, rheumatic diseases, and Alzheimer disease [8][9][10][11][12][13][14][15] . Therefore, patients with these diseases were excluded in order to examine the independent effect of age on endothelial function.…”

Section: Discussionmentioning

confidence: 99%

Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects

Yavuz¹,

Sener

Cankurtaran³

et al. 2008

Gerontology

View full text Add to dashboard Cite

Background: Aging is associated with an increased risk for atherosclerosis in which endothelial dysfunction is an early marker. Objective: The purpose of this study was to determine if endothelial function is altered with increasing age in healthy subjects. Method: The study population consisted of 30 elderly and 36 younger subjects free from major cardiovascular risk factors. Transthoracic echocardiography was performed for each subject to rule out structural heart disease. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery via ultrasound. Results: Baseline characteristics of the elderly and the younger group were similar, except for age (mean age: 71.3 ± 5.8 vs. 26.5 ± 7.2). Transthoracic echocardiography was normal in all subjects. FMD of the elderly group was significantly lower than the younger group (7.9 ± 3.1 in the elderly, 10.8 ± 1.9 in the younger group, p < 0.001). A negative relationship was found between FMD and age (r = –0.528, p < 0.001). Conclusion: It can be concluded that endothelial function detected by FMD declines with increasing age in healthy human subjects. Advanced age is a predictor of impaired endothelial function.

show abstract

Section: Discussionmentioning

confidence: 99%

Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects

Yavuz¹,

Sener

Cankurtaran³

et al. 2008

Gerontology

View full text Add to dashboard Cite

show abstract

“…Indeed, many commentators have noted that a number of vascular risk factors are likewise risk factors for Alzheimers, and that many measures which boost endothelial nitric oxide function are linked to decreased risk for this disorder. [25][26][27][28][29][30][31][32][33][34][35] Recent research has established that hypoxia boosts neuronal expression of BACE1 (a.k.a. beta-secretase), a protease whose activity can be rate-limiting for the production of the amyloid-beta peptides thought to drive the inflammatory process in Alzheimers.…”

mentioning

confidence: 99%

Potential complementarity of high-flavanol cocoa powder and spirulina for health protection

2010

View full text Add to dashboard Cite

“…In addition, recent data have shown that endothelial function is impaired in AD patients, suggesting that such dysfunction might represent a link between vascular and beta-amyloid hypothesis of Alzheimer's disease [52][53][54]. The endothelium is a monolayer of endothelial cells lining the lumen of the vascular beds and is mechanically and metabolically located, separating the vascular wall from the circulation and the blood components [55].…”

Section: Discussionmentioning

confidence: 99%

Brain Atrophy, Anti-Smooth Muscle Antibody and Cognitive Impairment: An Association Study

et al. 2016

View full text Add to dashboard Cite

Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum suggesting that AD could be another autoimmune disease and provides a link between vascular pathology, endothelium dysfunction and neuronal cells death. Aim of the present study was to evaluate the association between autoantibody profile and cognitive impairment in geriatric patients, accounting for ApoE genotype as a potential confounding factor. Three hundred and forty-four geriatric patients, attending the clinic for the cognitive decline, underwent a biochemical and immunological profile, chest X-ray, cerebral computed tomography scan and complete cognitive evaluation. All patients were also screened for the ApoE genotype.

show abstract

Assessment of Endothelial Function in Alzheimer's Disease: Is Alzheimer's Disease a Vascular Disease?

Abstract: Endothelial function is impaired in patients with AD. Endothelial function was worse in patients with severe AD. These findings provide evidence that vascular factors have a role in the pathogenesis of AD.

Cited by 119 publications

References 28 publications

Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects

Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects

Potential complementarity of high-flavanol cocoa powder and spirulina for health protection

Brain Atrophy, Anti-Smooth Muscle Antibody and Cognitive Impairment: An Association Study

Contact Info

Product

Resources

About