Assessment of enduracidin production from sweet sorghum juice by Streptomyces fungicidicus M30

Lü, Ling; Li, Wenjian; Hu, Wei; Pan, Xiaohong; Tian, Xue‐jiao; Mao, Yan-qin; Chen, Jihong

doi:10.1016/j.indcrop.2019.05.065

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…Interestingly, in the study by Andrzejewski et al [ 24 ], who developed a commercially viable hot lime clarification method to clarify sweet sorghum juice, which was beneficial to downstream microbial fermentation utilization. Using this method, Liu et al also proved that fermentation efficiency of enduracidin yield from clarified sweet sorghum juice was improved [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Conversion sweet sorghum biomass to produce value-added products

Zhou

Chen

2022

Biotechnol Biofuels

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Currently, most biotechnological products are produced from sugar- or starch-containing crops via microbial conversion, but accelerating the conflict with food supply. Thus, it has become increasingly interesting for industrial biotechnology to seek alternative non-food feedstock, such as sweet sorghum. Value-added chemical production from sweet sorghum not only alleviates dependency and conflict for traditional starch feedstocks (especially corn), but also improves efficient utilization of semi‐arid agricultural land resources, especially for China. Sweet sorghum is rich in components, such as fermentable carbohydrates, insoluble lignocellulosic parts and bioactive compounds, making it more likely to produce value-added chemicals. Thus, this review highlights detailed bioconversion methods and its applications for the production of value-added products from sweet sorghum biomass. Moreover, strategies and new perspectives on improving the production economics of sweet sorghum biomass utilization are also discussed, aiming to develop a competitive sweet sorghum-based economy.

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Section: Introductionmentioning

confidence: 99%

Conversion sweet sorghum biomass to produce value-added products

Zhou

Chen

2022

Biotechnol Biofuels

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“…A number of fuels and bio-chemicals have been successfully produced using sweet sorghum juice (SSJ) as feedstocks [7][8][9][10][11][12]. In a previous study, we have shown that SSJ was the preferred feedstock for enduracidin production with approximately equivalent e ciency to that of glucose, and S. fungicidicus M30 can also produce 1.01 ± 0.05 g/L of enduracidin via clari cated SSJ and fed-batch strategy [13]. However, the fermentation e ciency of S. fungicidicus M30 still needed to be further enhanced for industrial fermentation application.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Enduracidin Accumulation from Sweet Sorghum Juice via Alleviation of Oxidative Damage in Streptomyces Fungicidicus M30

Lü

Chen

et al. 2020

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Abstract Background: Sweet sorghum juice is the preferred feedstock for enduracidin production, but the fermentation efficiency still need to be further enhanced. Oxygen-mediated microbial cell damage is an effective way to boost cell growth and metabolite accumulation in aerobic fermentation. However, this strategy on enduracidin production from sweet sorghum juice has not been reported yet. Results: In this study, enduracidin production titer was significantly enhanced when 90 mM Vitamin C was added at 4 d of fermentation. The enhanced T-AOC and antioxidant enzyme activities may help to further understand the mechanism of Vitamin C effect on regulation of enduracidin accumulation in S. fungicidicus M30. The effects of chemical preservative methyl paraben on cell growth and enduracidin production were also evaluated, and 0.04 g/L of methyl paraben had no significant inhibitory effect on cell growth and enduracidin production, indicating that the concentrated sweet sorghum juice assisted by methyl paraben for a long-term storage can be used as the substrate for enduracidin production effectively. Finally, based on the group with 0.04 g/L of methyl paraben and 90 mM Vitamin C, a final enduracidin concentration of 1.14 g/L was achieved from clarificated sweet sorghum juice by M30 strain. Conclusions: This work provided a promising strategy to enhance enduracidin production using sweet sorghum juice via adding the antioxidant to boost antioxidant capacity in S. fungicidicus.

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