2001
DOI: 10.1053/ajkd.2001.22079
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Assessment of erythropoiesis activity during hemodialysis therapy by soluble transferrin receptor levels and ferrokinetic measurements

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Cited by 16 publications
(7 citation statements)
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“…Contrary to that, Hb and HCT levels showed a significant increasing linear trend. In addition, sTfR was significantly correlated with the Hb, HCT, RET%, rhEPO dose, and rate of chalybeate use, indicating that sTfR could be used as a marker of erythropoiesis, which is also consistent with previous studies [17][18][19][20][22][23][24][25]. Only one (TIBC) out of the four iron parameters was negatively correlated with sTfR, indicating that sTfR could not accurately reflect the iron status of HFD patients in our study.…”
Section: Discussionsupporting
confidence: 77%
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“…Contrary to that, Hb and HCT levels showed a significant increasing linear trend. In addition, sTfR was significantly correlated with the Hb, HCT, RET%, rhEPO dose, and rate of chalybeate use, indicating that sTfR could be used as a marker of erythropoiesis, which is also consistent with previous studies [17][18][19][20][22][23][24][25]. Only one (TIBC) out of the four iron parameters was negatively correlated with sTfR, indicating that sTfR could not accurately reflect the iron status of HFD patients in our study.…”
Section: Discussionsupporting
confidence: 77%
“…Furthermore, low iron stores caused elevated levels of sTfR, and this was not affected by age, sex, tissue injury, or acute phase inflammation [18]. In addition, sTfR is a marker of erythropoiesis [17][18][19][20]. So far, no study has investigated sTfR levels in patients treated with HFD.…”
Section: Introductionmentioning
confidence: 99%
“…14 Also, the tendency of heparin to increase sTFR could signalise erythropoiesis activation. 15 Typically, sTFR concentration is not increased in anaemia of chronic inflammation, but rather in cases of iron-deficient erythropoiesis; however, it does rise when both conditions co-exist. 16 Furthermore, while a decrease in haemoglobin levels is notable in our results, this is to be expected considering the nature of the critically ill patients, who accumulate a non-negligible number of aetiologies (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…If sTfR was mostly a marker of functional iron deficiency induced by rHuEpo, it should increase more consistently in nonresponders (primary cause of failure is functional iron deficiency) than in responders: in fact the reverse is true [33,118]. In addition, sTfR increments correlate well with later hematocrit increases [32], whereas levels are not different in patients with low or high ferritin [119] and correction of iron deficiency with oral iron is associated with little changes [118,120]. Furthermore, the elevation of sTfR in response to rHuEpo is larger in iron overloaded rats than in normal animals who develop functional iron deficiency [121].…”
Section: Soluble Tfr: a Marker Of Iron Status And/or Erythropoiesis?mentioning
confidence: 99%