Assessment of essential and non-essential elements in selected traditional medicines from India, Ghana and China

Gyamfi, Eva Tabuaa

doi:10.1007/s11356-020-10607-4

Cited by 6 publications

(3 citation statements)

References 69 publications

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“…The mean content of 55 Mn and 66 Zn was 26 and 21 μg/g, respectively. The content of Mn element was lower than the mean content of Mn in 39 traditional Chinese medicines reported by Gyamfi, and the content of Zn is slightly higher 29 . The highest 55 Mn level was found in samples from Wen county and the highest 66 Zn level was found in Zhang county.…”

Section: Resultscontrasting

confidence: 57%

Intra-regional classification of Codonopsis Radix produced in Gansu province (China) by multi-elemental analysis and chemometric tools

Bai

Wang

Fan

et al. 2022

Sci Rep

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Multi-elemental analysis is widely used to identify the geographical origins of plants. The purpose of this study was to explore the feasibility of combining chemometrics with multi-element analysis for classification of Codonopsis Radix from different producing regions of Gansu province (China). A total of 117 Codonopsis Radix samples from 7 counties of Gansu province were collected. Inductively coupled plasma mass spectrometry (ICP-MS) was used for the determination of 28 elements (39 K, 24 Mg, 44Ca, 27Al, 137Ba, 57Fe, 23Na, 88Sr, 55Mn, 66Zn, 65Cu, 85Rb, 61Ni, 53Cr, 51 V, 7Li, 208Pb, 59Co, 75As, 133Cs, 71 Ga, 77Se, 205Tl, 114Cd, 238U, 107Ag, 4Be and 202Hg). Among macro elements, 39 K showed the highest level, whereas 23Na was found to have the lowest content value. Micro elements showed the concentrations order of: 88Sr > 55Mn > 66Zn > 85Rb > 65Cu. Among trace elements, 53Cr and 61Ni showed higher content and 4Be was not detected in all samples. Intra-regions differentiation was performed by principal component analysis (PCA), cluster analysis (CA) and supervised learning algorithms such as linear discriminant analysis (LDA), k-nearest neighbors (k-NN), support vector machines (SVM), and random forests (RF). Among them, the RF model performed the best with an accuracy rate of 78.79%. Multi-elemental analysis combined with RF was a reliable method to identify the origins of Codonopsis Radix in Gansu province.

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Section: Resultscontrasting

confidence: 57%

Intra-regional classification of Codonopsis Radix produced in Gansu province (China) by multi-elemental analysis and chemometric tools

Bai

Wang

Fan

et al. 2022

Sci Rep

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“…In the Tibetan medicine “ Renqing Changjue ”, changes in element concentrations, including Cu, in biofluids and tissues were examined, and the precautions with long-term administration are pointed out [ 36 ]. The amount of Cu was the highest among 18 elements in QSW and varied 10-fold (1807–19430 μ g/kg), similar to the copper content variation (10-fold) in other traditional medicines [ 37 ]. A low amount of CuS could compromise its therapeutic effects, but a high amount of Cu could be toxic, especially for long-term administration.…”

Section: Discussionmentioning

confidence: 61%

Determination of 18 Trace Elements in 10 Batches of the Tibetan Medicine Qishiwei Zhenzhu Pills by Direct Inductively Coupled Plasma-Mass Spectrometry

Song

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Qishiwei Zhenzhu pills (QSW) was first recorded in the Tibetan medicine classic Si Bu Yi Dian and has been used to treat “Baimai” disease, stroke, paralysis, hemiplegia, cerebral hemorrhage, and other diseases till today. This prescription contains more than 70 medicines including myrobalan, pearl, agate, opal, bezoar, coral, musk, gold, silver, and a mineral mixture Zuotai. As a result, QSW contains a large amount of mercury, copper, lead, and other trace elements. The aim of this study was to determine the 18 trace elements (lithium, beryllium, scandium, vanadium, chromium, manganese, cobalt, nickel, copper, arsenic, strontium, argentum, cadmium, cesium, barium, lead, aurum, and mercury) in 10 batches of QSW produced by 5 pharmaceutical companies (Ganlu Tibetan Medicine Co., Ltd. has 6 different batches) by direct inductively coupled plasma-mass spectrometry (ICP-MS). ICP-MS is a rapid, sensitive, accurate methodology allowing the determination of 18 elements simultaneously. The results showed that each element had an excellent linear relationship in the corresponding mass concentration range. The results showed that the rank order of the elements in QSW was copper > mercury > lead from high to low, with the mass fraction higher than 6000 μg/kg; the mass fractions of argentum, arsenic, manganese, aurum, strontium, barium, chromium, and nickel were in the range of 33–1034 μg/kg; and the mass fractions of vanadium, cobalt, lithium, beryllium, cadmium, scandium, and cesium were lower than 10 μg/kg. The reproducibility from the same manufacturer (Tibet Ganlu Tibetan Medicine Co., Ltd.) was relatively high; however, the element amounts among 5 manufacturers were different, which could affect the efficacy and toxicity of QSW. All in all, ICP-MS can be used as an effective tool for the analysis of trace elements in QSW and standard quality control needs to be enforced across different manufactures.

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“…Being passed on from generation to generation, traditional recipes were unanimously regarded as confidential and the majority of THs were not willing to share the specifics of their treatment. This confidentiality limits opportunities to research the pharmacological properties of the remedies and can form a barrier to the collaboration between THs and allopathic healthcare providers [34].…”

Section: Discussionmentioning

confidence: 99%

Traditional healers' perception on scabies causation and management in Ghana

Tehrani,

Vos,

Kisabacak

et al. 2024

Tropical Med Int Health

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IntroductionScabies is an underdiagnosed skin infestation caused by the Sarcoptes scabiei mite. The infection causes severe itching and a skin rash but can be effectively treated using topical or systemic drugs. Scabies outbreaks are commonly reported in resource‐poor countries, including Ghana. Traditional healers play an important role in primary care in rural areas. The role of these traditional healers in the management of scabies has so far not been explored. The aim of this study was therefore to investigate the perceptions of traditional healers regarding the causation and management of scabies.MethodsA phenomenological qualitative approach was employed. Traditional healers in the Asante Akim North and Central districts in Ghana were approached with an interview request. Using a semi‐structured interview protocol, 15 traditional healers were interviewed. The results were coded and analysed, after which seven themes were extrapolated.ResultsScabies infections were frequently reported by traditional healers. Itching and skin rash were unanimously regarded as the major symptoms of scabies. The majority acknowledged the infectious nature of scabies, but no participant reported the causative organism. A dichotomous disease classification was noted, consisting of ‘natural’ and ‘spiritual’ variants each with a unique disease profile and management requirements, as reported by the traditional healers. All but two traditional healers reported to treat scabies using almost exclusively herbs and spiritual rituals.ConclusionThe majority of traditional healers were open to collaboration with allopathic healthcare providers. Collaboration could broaden the primary care network in rural areas, but mistrust and lack of transparency form potential barriers to collaboration. We, therefore, emphasise the need for additional efforts to investigate strategies for future collaboration.

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Assessment of essential and non-essential elements in selected traditional medicines from India, Ghana and China

Cited by 6 publications

References 69 publications

Intra-regional classification of Codonopsis Radix produced in Gansu province (China) by multi-elemental analysis and chemometric tools

Intra-regional classification of Codonopsis Radix produced in Gansu province (China) by multi-elemental analysis and chemometric tools

Determination of 18 Trace Elements in 10 Batches of the Tibetan Medicine Qishiwei Zhenzhu Pills by Direct Inductively Coupled Plasma-Mass Spectrometry

Traditional healers' perception on scabies causation and management in Ghana

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