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Emerging energy harvesting yarns, via triboelectric effects, have wide application prospects in new‐generation wearable electronics. However, few studies have been carried out regarding simultaneously achieving high electrical performance, mechanical robustness, and comfortability in industrial‐scalable yarn. Here, an electronic yarn twisted into Fermat spiral, which has outstanding dynamic structure stability, is reported. The Fermat‐spiral‐based energy yarns (FSBEY) can simultaneously realize ultrahigh abrasion resistance (over 5000 Martindale standard abrasion cycles), stable reversible strain (100%), and excellent electrical output. Considerably high output (105 V, ≈1.2 µA under 2 Hz) can be attained upon contacting a single yarn (30 cm) with latex material, which is superior to most state‐of‐the‐art stretchable triboelectric yarns. The application of these FSBEY in wireless gesture recognition, smart screen information protection, and harvesting of energy from water dropletsis demonstrated. Moreover, textiles knitted from the FSBEY have distinguished waterproof nature and are breathable. This work shows a feasible proposal for building future “energy garments”.

The bromodomain and extra-terminal domain (BET) family of proteins are readers which specifically recognize histone-acetylated lysine residues. Each BET bromodomain protein contains two highly homologous domains: the first bromodomain (BD1) and the second bromodomain (BD2). Pan-BET bromodomain inhibition is a potential therapy for various cancers and immune-inflammatory diseases, but only few reported inhibitors show selectivity within the BET family. Herein, we identified a series of benzo­[cd]­indol-2­(1H)-ones and pyrrolo­[4,3,2-de]­quinolin-2­(1H)-ones with good selectivity for BET BD1. Through structure-based optimization, highly active and selective compounds are ultimately obtained. The representative compounds are the first reported inhibitors with selectivity more than 100-fold for BRD4(1) over BRD4(2). Among them, we further show that 68 (LT052) mediates BRD4/NF-κB/NLRP3 signaling inflammatory pathways with comparable protein expression and significantly improves symptoms of gout arthritis in a rat model. Therefore, selective pharmacological modulation of individual bromodomains could represent a strategy for the treatment of acute gouty arthritis.

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