Assessment of factor V, VII and X activities, the key coagulant proteins of the tissue factor pathway in poultry plasma

Thomson, A E; Squires, E. J.; Gentry, Patricia A.

doi:10.1080/00071660120121553

Cited by 27 publications

(16 citation statements)

References 23 publications

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“…Regarding the coagulation system, VKOR of chickens and ostriches could be thought to be a poor supplier of vitamin K in the coagulation system. The coagulation system or the coagulation factors of avian species can be different from mammal (Thomson et al, 2002). In ostriches, the vitamin K-dependent coagulation factors, such as factor II, IIV, IX and X, are known to have low or no activity (Frost et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Comparison of warfarin sensitivity between rat and bird species

Watanabe

Saengtienchai

Tanaka

et al. 2010

Comparative Biochemistry and Physiology Part C: Toxicology &

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Scattering coumarin-derivative rodenticides in broad areas have caused primary-and secondary-poisoning incidents in non-target wild birds. In this study, we compared factors determining warfarin sensitivity between bird species and rats based on vitamin K 2,3-epoxide reductase (VKOR) kinetics, VKOR inhibition by warfarin and warfarin metabolism assays. In VKOR characterization, chickens and ostriches showed significantly lower enzymatic efficiencies than rats (one-sixth and one-third, respectively), suggesting bird species depend more on a non-VKOR vitamin K source. On the other hand, the inhibition constants (K i ) of VKOR for warfarin were significantly different between chickens and ostriches (11.3 ± 2.5 μM and 0.64 ± 0.39 μM, respectively). Interestingly, the ostrich K i was similar to the values for rats (0.28 ± 0.09 μM). The K i results reveal a surprising possibility that VKOR in some bird species are easily inhibited by warfarin. Warfarin metabolism assays also showed a large inter-species difference in bird species. Chickens and ostriches showed higher metabolic activity than that of rats, while mallards and owls showed only a slight ability to metabolize warfarin. In this study, we clarified the wide inter-species difference that exists among birds in xenobiotic metabolism and sensitivity to a rodenticide.

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Section: Discussionmentioning

confidence: 99%

Comparison of warfarin sensitivity between rat and bird species

Watanabe

Saengtienchai

Tanaka

et al. 2010

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…The biological activity of Factors V, VII and X was measured using a modification of the onestage prothrombin time assay with chicken tissue factor (cTF) prepared as previously described (Thomson et al, 2002). The activity of Factors VIII and IX was estimated using a modification of the Activated Partial Thromboplastin Time assay.…”

Section: Determination Of Coagulation Factor Activitymentioning

confidence: 99%

Comparison of the coagulation profile of Fatty Liver Haemorrhagic Syndrome-susceptible laying hens and normal laying hens

Thomson

Gentry

Squires

2003

British Poultry Science

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1. The rate of thrombin generation in plasma from Fatty Liver Haemorrhagic Syndrome-susceptible laying hens (FLHS, UCD-003) is more rapid than in plasma from age-matched normal Single Comb White Leghorn (SCWL) laying hens. 2. The rate of thrombin generation in plasma was determined by measuring the biological activity of the specific coagulation proteins, Factors V, VII, VIII, IX and X. 3. The higher activity of Factors V, VII and X in FLHS-susceptible laying hens compared with normal SCWL hens remained consistent after plasma lipid concentrations were reduced. 4. Analysis of the fatty acid composition of plasma phospholipids showed that in normal SCWL laying hens phosphatidylethanolamine contained C18:3n3 whereas it contained C20:3n3 in FLHS-susceptible laying hens. 5. The results suggest that alterations in the composition of the phospholipids that are essential cofactors in the biochemical reactions involved in thrombin generation may be a contributing factor in the development of FLHS.

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“…Menadione (vitamin K3) is predicted to target coagulation factor III (tissue factor, F3). According to DrugBank, Menadione is involved as a cofactor of vitamin K-dependent coagulation factors II, VII, IX, and X, two of which are known to be part of the tissue factor pathway (Thomson et al, 2002). In addition, tissue factor is known to be targeted by coagulation factor VIIa, which is itself a vitamin K-dependent glycoprotein.…”

Section: Novel Predictionsmentioning

confidence: 99%

Combining Drug and Gene Similarity Measures for Drug-Target Elucidation

Perlman¹,

Gottlieb

Atias

et al. 2011

Journal of Computational Biology

183

131

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Understanding drugs and their modes of action is a fundamental challenge in systems medicine. Key to addressing this challenge is the elucidation of drug targets, an important step in the search for new drugs or novel targets for existing drugs. Incorporating multiple biological information sources is of essence for improving the accuracy of drug target prediction. In this article, we introduce a novel framework-Similarity-based Inference of drug-TARgets (SITAR)-for incorporating multiple drug-drug and gene-gene similarity measures for drug target prediction. The framework consists of a new scoring scheme for drug-gene associations based on a given pair of drug-drug and gene-gene similarity measures, combined with a logistic regression component that integrates the scores of multiple measures to yield the final association score. We apply our framework to predict targets for hundreds of drugs using both commonly used and novel drug-drug and gene-gene similarity measures and compare our results to existing state of the art methods, markedly outperforming them. We then employ our framework to make novel target predictions for hundreds of drugs; we validate these predictions via curated databases that were not used in the learning stage. Our framework provides an extensible platform for incorporating additional emerging similarity measures among drugs and genes. Supplementary Material is available at www.liebertonline .com/cmb.

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Assessment of factor V, VII and X activities, the key coagulant proteins of the tissue factor pathway in poultry plasma

Cited by 27 publications

References 23 publications

Comparison of warfarin sensitivity between rat and bird species

Comparison of warfarin sensitivity between rat and bird species

Comparison of the coagulation profile of Fatty Liver Haemorrhagic Syndrome-susceptible laying hens and normal laying hens

Combining Drug and Gene Similarity Measures for Drug-Target Elucidation

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