Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography

Fukushima, Akimune; Nakai, Kenta; Itoh, Masatoshi; Horigome, Hitoshi; Suwabe, Akira; Tohyama, Kojirou; Kobayashi, Kouichiro; Yoshizawa, Michito; Sugiyama, Toru

doi:10.4137/cmc.s355

Cited by 7 publications

(13 citation statements)

References 31 publications

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“…21) Because fetal evoked MEGs may be difficult to perform as a general clinical application, we reviewed the significance of fetal heart rate variability for evaluating fetal ANS activity. Using a 64-ch MCG, Fukushima, et al found that the activity of the sympathetic and parasympathetic nervous systems, as evaluated from the LF/HF ratio, were enhanced at gestational ages of 32 weeks and later, 13) consistent with previous reports of a conversion point at 32 weeks of gestation. 22,23) We found that the ANS activity, as evaluated by the CV and LF/ HF ratio using SAVP-ECG, was remarkably enhanced just after birth.…”

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confidence: 70%

Development and Significance of a Fetal Electrocardiogram Recorded by Signal-Averaged High-Amplification Electrocardiography

et al. 2009

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SummaryAlthough ultrasonic diagnostic imaging and fetal heart monitors have undergone great technological improvements, the development and use of fetal electrocardiograms to evaluate fetal arrhythmias and autonomic nervous activity have not been fully established. We verified the clinical significance of the novel signal-averaged vector-projected high amplification ECG (SAVP-ECG) method in fetuses from 48 gravidas at 32-41 weeks of gestation and in 34 neonates. SAVP-ECGs from fetuses and newborns were recorded using a modified XYZ-leads system. Once noise and maternal QRS waves were removed, the P, QRS, and T wave intervals were measured from the signal-averaged fetal ECGs. We also compared fetal and neonatal heart rates (HRs), coefficients of variation of heart rate variability (CV) as a parasympathetic nervous activity, and the ratio of low to high frequency (LF/HF ratio) as a sympathetic nervous activity. The rate of detection of a fetal ECG by SAVP-ECG was 72.9%, and the fetal and neonatal QRS and QTc intervals were not significantly different. The neonatal CVs and LF/HF ratios were significantly increased compared with those in the fetus. In conclusion, we have developed a fetal ECG recording method using the SAVP-ECG system, which we used to evaluate autonomic nervous system development. (Int Heart J 2009; 50: 161-171)

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confidence: 70%

Development and Significance of a Fetal Electrocardiogram Recorded by Signal-Averaged High-Amplification Electrocardiography

et al. 2009

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“…11). Inter-group changes in LF/HF in the normal group increased significantly with gestation period (one-way ANOVA: P = 0.003) [7,8] (Fig. 12).…”

Section: Sustained Vt -Sinus Rhythm Sinus Rhythmmentioning

confidence: 88%

“…CV RR over the gestational age periods in normal pregnancy showed no statistical differences on one-way ANOVA [7,8] ( Fig. 10).…”

Section: Sustained Vt -Sinus Rhythm Sinus Rhythmmentioning

confidence: 94%

“…As MCG enables noncontact, noninvasive measurement, fetal MCG (FMCG) is regarded as exceptionally useful for the analysis of fetal electrocardiographic phenomena. In re-*Address correspondence to this author at the 19-1 Uchimaru, Morioka, Iwate 020-8505 Japan; Tel: +81-19-651-5111; Fax: +81-19-651-5111; E-mail: akimunef@iwate-med.ac.jp cent years, FMCG has also been used in a wide range of clinical applications in the field of prenatal treatment [1][2][3][4][5][6][7][8][9]. We herein report our use of MCG for the diagnosis of fetal arrhythmias, and to perform an analysis of fetal autonomic nervous system activity.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal Diagnosis of Fetal Arrhythmias and Assessment of Autonomic Nervous System Activity by Fetal Magnetocardiography

Fukushima

Matsumoto²,

Terata³

et al. 2012

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Magnetocardiography (MCG) is a technique that enables the noncontact, noninvasive measurement of electrocardiographic phenomena, and fetal magnetocardiography (FMCG) is extremely useful for the analysis of fetal electrocardiographic phenomena. We have used FMCG for the diagnosis and treatment of a range of fetal arrhythmias, and to perform comparative studies of autonomic nervous system activity in fetuses with normal growth and those with fetal growth restriction by analyzing fetal heart rate variability. In terms of fetal arrhythmias, fatal long QT syndrome was accurately diagnosed prenatally using FMCG, and pregnancy was maintained until delivery at 37 weeks gestation. With regard to fetal autonomic nervous system activity, there was a pronounced increase in sympathetic nervous activity among fetuses with normal growth in the second half of pregnancy.

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“…It is known that the fetal autonomic nervous system and cardiac function develop as gestation progresses [56], and these functions are reflected in the correlation of fetal heart rate fluctuations with gestational age [7]. Therefore, it is important to study how fetal cardiac function responds to postural changes, as gestational age increases.…”

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confidence: 99%

Adaptive responses of cardiac function to fetal postural change as gestational age increases

et al. 2016

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ObjectiveThe cardiovascular system maintains homeostasis through a series of adaptive responses to physiological requirements. However, little is known about the adaptation of fetal cardiac function to gravity, according to gestational age. In the present study, we aimed to evaluate the adaptive responses of cardiac function to postural changes, using Tei index measurements.MethodsFetal echocardiography and Doppler examination were performed on 114 women with vertex singleton pregnancies at 19 to 40 weeks' gestation. Participants were placed in an upright seated position, and the Tei index for fetal left ventricular cardiac function was measured. The women were then moved into a supine position and the Tei index was re-measured.ResultsThe mean Tei index when measured in an upright seated position was significantly lower than that measured in a supine positioning for all fetuses (0.528±0.103 vs. 0.555±0.106, P=0.014, respectively). This difference was also noted in fetuses with a gestational age of 28–40 weeks (0.539±0.107 vs. 0.574±0.102, P=0.011, respectively). However, there was no difference in the Tei index between an upright seated and a supine position among fetuses with a gestational age of <28 weeks (0.505±0.091 vs. 0.516±0.103, P=0.571, respectively).ConclusionPostural changes from an upright seated to a supine position result in an increased Tei index after a gestational age of 28 weeks. This appears to reflect maturation in the adaptive responses of the fetal cardiovascular system to postural changes.

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Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography

Cited by 7 publications

References 31 publications

Development and Significance of a Fetal Electrocardiogram Recorded by Signal-Averaged High-Amplification Electrocardiography

Development and Significance of a Fetal Electrocardiogram Recorded by Signal-Averaged High-Amplification Electrocardiography

Prenatal Diagnosis of Fetal Arrhythmias and Assessment of Autonomic Nervous System Activity by Fetal Magnetocardiography

Adaptive responses of cardiac function to fetal postural change as gestational age increases

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