Assessment of fipronil toxicity on wistar rats: A hepatotoxic perspective

Kartheek, R.M.; David, Muniswamy

doi:10.1016/j.toxrep.2018.02.019

Cited by 39 publications

(21 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also altered the 5-HT tissue content. Previous studies showed that FPN dose-dependently changed the activity of various enzymes involved in oxidative stress and inflammation in the brain when chronically administered at the 5–30 mg/kg range of doses [ 8 , 9 , 11 , 12 , 38 ]. Thus, the dose of 10 mg/kg, considered as a moderate dose, profoundly alters the neurochemistry of monoamines, particularly DA and 5-HT.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it confirms that FPN quantitatively induces marked alterations in nigrostriatal DAergic systems and extends these alterations to the raphe-striatal and raphe-nigral 5-HTergic systems, which appear to play an important role. In terms of environmental pollution, the dose used was likely high with respect to its concentration that could be absorbed [ 10 , 38 ], and it would deserve additional expertise at 3–10 times lower doses. Nonetheless, FPN or one of the studied metabolite - fipronil sulfone has a long half-life and can stay in the tissue for days [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…After handling for 10 days for acclimation to the vivarium conditions (UMR 5287 Institute, University of Bordeaux; agreement B33-063-269), the rats were divided in two treatment groups: the control group, which received drinking water (1 mL/kg); and the FPN-treated group, which received the pesticide (10 mg/kg) suspended in the same volume of drinking water as in the control group [ 38 ]. The rats were given chronic treatment once daily, by oral gavage, for 21 days.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Chronic Administration of Fipronil Heterogeneously Alters the Neurochemistry of Monoaminergic Systems in the Rat Brain

Bharatiya

Chagraoui

Deurwaerdere

et al. 2020

IJMS

View full text Add to dashboard Cite

Fipronil (FPN), a widely used pesticide for agricultural and non-agricultural pest control, is possibly neurotoxic for mammals. Brain monoaminergic systems, involved in virtually all brain functions, have been shown to be sensitive to numerous pesticides. Here, we addressed the hypothesis that chronic exposure to FPN could modify brain monoamine neurochemistry. FPN (10 mg/kg) was chronically administered for 21 days through oral gavage in rats. Thereafter, the tissue concentrations of dopamine (DA) and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid; serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA); and noradrenaline (NA) were measured in 30 distinct brain regions. FPN significantly decreased DA and its metabolite levels in most striatal territories, including the nucleus accumbens and the substantia nigra (SN). FPN also diminished 5-HT levels in some striatal regions and the SN. The indirect index of the turnovers, DOPAC/DA and 5-HIAA/5-HT ratios, was increased in numerous brain regions. FPN reduced the NA content only in the nucleus accumbens core. Using the Bravais–Pearson test to study the neurochemical organization of monoamines through multiple correlative analyses across the brain, we found fewer correlations for NA, DOPAC/DA, and 5-HIAA/5-HT ratios, and an altered pattern of correlations within and between monoamine systems. We therefore conclude that the chronic administration of FPN in rats induces massive and inhomogeneous changes in the DA and 5-HT systems in the brain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Administration of Fipronil Heterogeneously Alters the Neurochemistry of Monoaminergic Systems in the Rat Brain

Bharatiya

Chagraoui

Deurwaerdere

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Kartheek et al studied hepatotoxicity of Fipronil in wistar rats and found that Fipronil causes significant rise in levels of AST, ALT and ALP with hepatotoxicity effect lasting till 90 days at selected doses. [5] Recently, Pandit et al demonstrated pulmonary toxicity in mice models secondary to chronic exposure to low dose Fipronil. [6]…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity and neurotoxicity of Fipronil poisoning in human: A case report

Gutta

Gunasekaran

Iyadurai

2019

J Family Med Prim Care

View full text Add to dashboard Cite

Fipronil is an N-phenylprazole insecticide which is commonly used pesticide in south India. In animals it has been described to cause toxic manifestations mainly in the Gastro-intestinal (GI) and Central nervous system (CNS) and less commonly in kidney and liver. The available medical literature about toxic effects of Fipronil consumption in humans has been very little and mostly limited to acute GI and neurological manifestation mostly lasting for less than three days. We report the case of a 32-year-old gentleman who had consumed Fipronil (5%) in an attempt of deliberate self-harm. The patient had neurotoxicity features in the form of seizures and decreased sensorium requiring intensive medical care with mechanical ventilation and also had hepatotoxicity. Both hepatotoxicity and neurotoxicity lasted for nearly three weeks. The patient improved with supportive therapy and gradually overcame both the toxicities.

show abstract

“…It is found Major target organs of pesticides are liver and kidney which causes damage and toxicity (Mansour and Mossa, 2010;Abdel Rasoul and Marei, 2016). Insecticides encourage the induction of reactive oxygen species (ROS) and causing damage to lipids, proteins, enzymes, carbohydrates and nucleic acids (Fraga et al, 1996;Kartheek and David, 2018). Cyfluthrin is a synthetic pyrethroid vastly used in agriculture against grasshoppers and pests.…”

Section: Introductionmentioning

confidence: 99%

The Ameliorating Role of Geraniol Oil on Renal Toxicity Induced by Some Pesticides in Rats

Marei¹

2019

Alexandria Science Exchange Journal

View full text Add to dashboard Cite

The Defensive impact of geraniol (GeoH) against renal oxidative injury and nephrotoxicity induced by betacyfluthrin, (β-Cyf), fipronil(FPN). and their combined effects on the male rats were investigated. Eight categories, each category of male rats were used contain six rats. Category I as control, Category 2 GeOH (100 mg/kg bwt in corn oil). Categories 3, 4 and 5 rats have presented a single daily oral dose of (FPN) fipronil (4.85 mg/kg bwt), (β-Cyf ) beta-Cyfluthrin (19 mg/kg bwt)) and their combination. Categories 6, 7 and 8 rats have presented the same doses as Categories 3, 4 and 5 with GeOH (100 mg/kg) for 28 consecutive days, respectively. Rats which was exposed insecticides compared to control recorded significant decrease in body weight and rise in kidney weight. Treatment rats recorded significant renal function disruption by increase in uric acid and serum creatinine level. Also, insecticide-treated rats revealed renal oxidative damage was spotted in insecticide-treated rats through an increase in kidney lipid peroxidation (LPO) also, kidney appeared the decrease in antioxidant enzymes. Histopathological analysis of the kidney appeared that tubular destruction with multiple vacuolations, hyaline degeneration in glomeruli, and the thick arterial wall, and irregular glomerular lining in treated groups (FPN, β-Cyf, FPN + β-Cyf). In conclusion, the use of Geraniol (GeOH) seemed to be useful to rats, to a great extent by alleviation and decrease the damage sustained by insecticide exposure.

show abstract

Assessment of fipronil toxicity on wistar rats: A hepatotoxic perspective

Abstract: Graphical abstract

Cited by 39 publications

References 52 publications

Chronic Administration of Fipronil Heterogeneously Alters the Neurochemistry of Monoaminergic Systems in the Rat Brain

Chronic Administration of Fipronil Heterogeneously Alters the Neurochemistry of Monoaminergic Systems in the Rat Brain

Hepatotoxicity and neurotoxicity of Fipronil poisoning in human: A case report

The Ameliorating Role of Geraniol Oil on Renal Toxicity Induced by Some Pesticides in Rats

Contact Info

Product

Resources

About