Assessment of Functional Lung Impairment in Hypothyroidism

Roel, Sharon; Punyabati, O; Prasad, Lalta; Salam, Ranabir; Ningshen, Kanmi; Shimray, A. Jannie; Sangma, M A; Hungyo, Hongprachan; Devi, Ashem Nandarani

doi:10.9790/0853-13980407

Cited by 10 publications

(8 citation statements)

References 10 publications

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“…Roel et al . [ 14 ] in accordance with our results they observed that both FVC and FEV 1 reduced in hypothyroid patients compared to control, but only FVC was significantly reduced. Also each of Valjevac et al .…”

Section: Discussionsupporting

confidence: 93%

“…Roel et al . [ 14 ] supported our results; they observed a negative and positive correlation between spirometric parameters and each of TSH, and FT4, respectively. In addition, Bassi et al .…”

Section: Discussionsupporting

confidence: 88%

“…Furthermore, Roel et al . [ 14 ] attributed spirometric changes in hypothyroid patients to the reduced level of FT4 and subsequent hypoventilation and weakness of inspiratory muscle. By performing correlation study, we observed that FEV 1 %, and DLCO were significantly negatively correlated with TSH ( r = −0.424; P = 0.039, r = −0.566; P = 0.004, respectively), whereas they were significantly positively correlated with FT4 ( r = 0.584; P = 0.005, r = 0.457; P = 0.025, respectively) Figure 1 .…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary consequences of hypothyroidism

2017

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BACKGROUND:Although hypothyroidism has an insidious onset and relatively asymptomatic, exertional dyspnea and fatigue can be the presenting complaints.OBJECTIVES:The aim is to assess functional lung impairment in hypothyroid patients both at rest and during exercise.METHODS:A case-control study was carried out on 42 patients with newly diagnosed hypothyroidism and 12 control subjects. Hypothyroidism was diagnosed based on high value of thyroid stimulating hormone (TSH) ≥6 μIU/ml, and low value of free thyroxin (FT4) ≤0.8 ng/dl, both groups had chest X-ray, spirometry, diffusing capacity of the lungs for carbon monoxide (DLCO), arterial blood gases (ABGs) and symptom-limited exercise testing using treadmill.RESULTS:Both groups were comparable as regard age, sex, and body mass index. Although ABG and spirometry were within normal in both groups, forced vital capacity %, and forced expiratory flow (FEF25–75) % were significantly reduced in the hypothyroid group (P = 0.014, 0.000, respectively), DLCO significantly reduced in hypothyroidism (P = 0.005). As regard exercise testing parameters, maximum oxygen consumption %, minute ventilation, tidal volume, and oxygen pulse were significantly reduced in hypothyroidism (0.005, 0.000, 0.000, and 0.02 respectively). TSH significantly negatively correlated with forced expiratory volume in 1 s %, FEF25–75%, and DLCO while they significantly positively correlated with FT4.CONCLUSION:Even with the presence of normal chest X-ray, arterial blood gases, and spirometry in patients with hypothyroidism DLCO and exercise testing parameters can be significantly reduced.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Pulmonary consequences of hypothyroidism

2017

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“…Endocrine diseases in general have critical association with respiratory system [ 93 ] and thyroid hormones in particular play an important role in development of lungs and maturation of pulmonary surfactant [ 94 ]. Functional lung impairment has been observed in patients with hypothyroidism [ 95 , 96 , 97 ]. Moreover, respiratory dysfunctions has been studied to be more prevalent in hypothyroid patients [ 98 ].…”

Section: Disorders and Diseases Associated With Thyroid Dysfunctionmentioning

confidence: 99%

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Kumari

Chainy

Subudhi

2020

Heliyon

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“…Researchers have found that there are significant changes in physiological parameters in hypothyroidism which was not found in this study. 12,13 Figure 2: Distribution of family history of thyroid disease in the study group. The p value doesn't show any significance in physiological parameters with respect to gender.…”

Section: Figure 1: Gender Distribution Of Study Groupmentioning

confidence: 99%

Variations of physiological parameters in newly detected hypothyroidism

Seethalakshmi¹,

Bahuleyan

Menon

2019

Int J Res Med Sci

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Background: Emergence of hypothyroidism as a public health issue apart from a common clinical entity, has gained much attention nowadays. The non-specific features of hypothyroidism lead to incorrect diagnoses, inadequate treatment and complications in the future. The present study was designed to unravel the effects of hypothyroidism on physiological parameters and to highlight the importance of early diagnosis and treatment. This study was done to assess the effects of hypothyroidism on pulse rate, blood pressure and respiratory rate.Methods: This descriptive cross-sectional study was done in 60 hypothyroid patients of 18-45 years age, both males and females, who were either newly detected or on treatment for less than 6 months. Patients with history of other systemic diseases, pregnancy and hyperthyroidism were excluded. After obtaining written consent from the patients, clinical examination was done.Results: Student t-test and ANOVA were used for analysis. Physiological parameters like pulse rate, blood pressure and respiratory rate had variations in the patients and there were changes with age, gender and BMI even though they were not significant. These changes were attributed to increased arterial wall thickness and endothelial dysfunction in blood vessels.Conclusions: The patients showed changes in cardiovascular and respiratory profiles. The variations in systolic and diastolic blood pressures were significant with increase in age. Physiological parameters had variations with gender and BMI also. This proves the cardiovascular and respiratory morbidity in newly detected hypothyroidism, which emphasizes the importance of early diagnosis and treatment in them.

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Assessment of Functional Lung Impairment in Hypothyroidism

Cited by 10 publications

References 10 publications

Pulmonary consequences of hypothyroidism

Pulmonary consequences of hypothyroidism

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Variations of physiological parameters in newly detected hypothyroidism

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