Obesity is one of the world's health problems. The increase in obesity is associated with increasing degenerative diseases such as hypertension. Hypertension is one of the main risk factors for mortality in the world. One of comorbid disease in patients with hypertension will increase mortility is dyslipidemia or disorder of lipid profiles. The aim of this study to determine the comparison in lipid profiles between obesehypertensive and non hypertensive. A cross-sectional study was carried out among forty obese participants. Blood pressure measurement using a mercury sphygmomanometer. Hypertension was defined as systolic blood pressure (SBP) up to 140 mmHg and/or diastolic blood pressure (DBP) up to 90 mmHg. Serum lipid profiles such as total cholesterol (TC), lowdensity lipoprotein (LDL), triglycerides (TG) and high density lipoprotein (HDL were measured using the cobas 6000, series 501 after subjects had fasted for 12 hours. The results shows that seventeen of obese participants were hypertensive and twenty three were non hypertensive. The TC, LDL and TG levels increases in obese hypertensive more than in non-hypertensive while HDL decreases in hypertensive patients. The TC and TG level (mg/dl) in obese hypertensive compared in obese non hypertensive were 203.64 vs 183.25; 168.70 vs 112.91 which the independent-samples t test showed significant different. The present findings show that serum total cholesterol and triglyceride levels are significant changes in obese hypertensive patients than in obese non hypertensive.