Assessment of Headache in Asthma Patients

Güngen, Adil Can; Güngen, Belma Doğan

doi:10.12669/pjms.331.11720

Cited by 9 publications

(15 citation statements)

References 27 publications

(25 reference statements)

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“…Other factors such as the use of steroid inhalers, the presence of rhinitis, conjunctivitis or respiratory parameters, such as forced expiratory volume in one second, were studied and characterised. 36 In our study, being asthmatic would act as a protective factor against headache associated with mask use, perhaps because of a greater tolerance to hypoxia, and therefore a higher threshold for developing headache for this reason.…”

Section: Discussionmentioning

confidence: 69%

Mask-associated ‘de novo’ headache in healthcare workers during the COVID-19 pandemic

et al. 2020

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ObjectivesThe pandemic caused by the new coronavirus (COVID-19) has changed care activities of health professionals. We analysed the possible association between the appearance of ‘de novo’ headache according to the type of mask used, the related factors and the impact of the cephalalgia on health professionals.MethodsCross-sectional study in a tertiary hospital in Extremadura, Spain. We provided an online questionnaire to healthcare workers during the period of maximum incidence of COVID-19 in our setting.ResultsThe subjects are n=306, 244 women (79.7%), with an average age of 43 years (range 23–65). Of the total, 129 (42.2%) were physicians, 112 (36.6%) nurses and 65 (21.2%) other health workers. 208 (79.7%) used surgical masks and 53 (20.3%) used filter masks. Of all those surveyed, 158 (51.6%) presented ‘de novo’ headache. The occurrence of a headache was independently associated with the use of a filter mask, OR 2.14 (95% CI 1.07 to 4.32); being a nurse, OR 2.09 (95% CI 1.18 to 3.72) or another health worker, OR 6.94 (95% CI 3.01 to 16.04); or having a history of asthma, OR 0.29 (95% CI 0.09 to 0.89). According to the type of mask used, there were differences in headache intensity, and the impact of a headache in the subjects who used a filter mask was worse in all the aspects evaluated.ConclusionThe appearance of ‘de novo’ headache is associated with the use of filter masks and is more frequent in certain healthcare workers, causing a greater occupational, family, personal and social impact.

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Section: Discussionmentioning

confidence: 69%

Mask-associated ‘de novo’ headache in healthcare workers during the COVID-19 pandemic

et al. 2020

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“…Clinically, a considerable portion of asthma patients have comorbid headaches 19,20 , and it was questionable which disease was the first event. We postulated that asthma and migraine have reciprocal relationships with each other.…”

Section: Introductionmentioning

confidence: 99%

Bidirectional association between asthma and migraines in adults: Two longitudinal follow-up studies

Kim

Min

et al. 2019

Sci Rep

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the objective of this study was to evaluate the bidirectional association between asthma and migraines using control subjects matched by demographic factors. the Korean Health insurance Review and Assessment Service-National Sample Cohort from 2002 to 2013 was used. In study I, 113,059 asthma participants were matched with 113,059 control I participants. In study II, 36,044 migraine participants were matched with 114,176 control II participants. The hazard ratios (HRs) of migraines in the asthma patients (study I) and asthma in the migraine patients (study II) were analyzed using stratified Cox proportional hazard models after adjusting for depression and the Charlson comorbidity index. In study I, 5.3% (6,017/ 113,059) of the asthma group and 3.4% (3,806/ 113,059) of the control I group had migraines (P < 0.001). The asthma group demonstrated an adjusted HR of 1.47 for migraine (95% confidence interval (CI) = 1.41-1.53, P < 0.001). In study II, 15.4% (5,548/36,044) of the migraine group and 10.6% (15,271/144,176) of the control group had asthma (P < 0.001). The migraine group showed an adjusted HR of 1.37 for asthma (95% CI = 1.33-1.41, P value < 0.001). Asthma and migraines are reciprocally associated. Asthma is a chronic airway disease associated with clusters of respiratory symptoms, including wheezing and dyspnea. Asthma is a common disease with different prevalences according to ethnicity that range from approximately 7% to 18.0% 1. The incidence of asthma in the adult population (>20 years old) was estimated to be approximately 3.63-6.07 per 1,000 people in Korea 2. Because the diagnosis of asthma is based on the functional deterioration of the lower airway, the underlying pathophysiologic causes of asthma have been reported to vary among asthmatic patients 3. According to the pathophysiologic mechanisms, asthma is classified as two major endotypes of T-helper type 2 cell (TH2)-high and TH2-low diseases 4. Thus, in addition to TH2-high related diseases, such as allergic rhinitis, other immune-related diseases could complicate asthma. In addition, both genetic factors and environmental triggering factors have been suggested to be related to asthma 5,6. Migraine disorder is another chronic disease characterized by multiple symptoms of headache and/or aura. As many as approximately 1.04 billion people suffer from migraines worldwide (95% uncertainty interval = 1.00-1.09) 7. In Korea, approximately 6.0% of the adult population (19-69 years) suffers from migraines 8. Migraines are characterized by recurrent episodic symptom sequences of a premonitory phase, an aura phase, a headache phase, and a postdrome phase 9. The environmental triggering factors can hyper-activate the hypothalamic-pituitary-adrenocortical axis and autonomic nervous system in migraine susceptible subjects 10. These hormonal and nervous changes induce vasodilation, the release of vascular factors, including growth factors, cytokines, nitric oxide, norepinephrine and calcitonin gene-related peptide, and interaction with endothelial cells, res...

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“…13 Literatürde, astımlı hastalarda migren insidansı %16-32 arasında bildirilmektedir. 21,[31][32][33] Çalışmamızda bu oran %35,4 olarak saptanmıştır. Araştırmalarda kadınlarda erkeklere göre migren görülme oranının yüksek olduğu bildirilirken, çalışmamızda oran benzer bulunmuştur.…”

Section: Gereç Ve Yöntemlerunclassified

“…Araştırmalarda kadınlarda erkeklere göre migren görülme oranının yüksek olduğu bildirilirken, çalışmamızda oran benzer bulunmuştur. [31][32][33] Çalışmamızın sınırlayıcı faktörlerinden biri, hastalarımızın kesitsel olarak değerlendirmelerinin yapılıp, uzun süreli izlem yapılmamış olmasıdır. Hasta sayımızın da nispeten azlığı ikinci bir sınırlayıcı faktördür.…”

Section: Gereç Ve Yöntemlerunclassified